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All Journal Alotrop Jurnal Pendidikan dan Ilmu Kimia Konservasi Hayati
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology

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ANTIDIABETIC POTENTIAL OF SOLID LIPID NANOPARTICLES (SLNS) FROM KABAU SEED (ARCHIDENDRON BUBALINUM (JACK) I.C. NIELSEN) EXTRACT COATED WITH TRIMYRISTIN Balqis, Solina; Diah Miftahul Aini; Muhammad Arif Fadilah; Nurkayah; Mu'awiyatu Al-Laitsi; Lia Aseptin Murdini; Elva Febriyanti
ALOTROP Vol. 9 No. 1 (2025): Jurnal Pendidikan dan Ilmu Kimia
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v9i1.42075

Abstract

Type 2 diabetes mellitus is a global health problem that continues to increase. One alternative approach in managing diabetes is using natural materials with antihyperglycemic activity. This study aims to evaluate the effectiveness of solid lipid nanoparticles (SLN) containing Kabau seed extract (Archidendron bubalinum (Jack) I.C. Nielsen) coated with trimyristin in reducing blood glucose levels in hyperglycemic rats. Extraction was carried out by maceration using 96% ethanol, while SLN was synthesized by high-speed homogenization and ultrasonication methods. Particle size analysis showed an average diameter of 262.61 nm with a polydispersity index (PDI) of 0.144, indicating a homogeneous formulation. Phytochemical testing showed that Kabau seed extract contains alkaloids, flavonoids, tannins, and saponins contributing to antihyperglycemic activity. In vivo tests on Mus musculus showed that 20 % concentration of Kabau SLN reduced blood glucose levels by up to 97 mg/dL, approaching the effectiveness of metformin (104 mg/dL). Statistical analysis of ANOVA and BNT test showed significant differences between treatments. These results indicate that Kabau SLN has the potential as a candidate for phytopharmaceuticals in managing type 2 diabetes mellitus. Keywords: Diabetes mellitus; Kabau; solid lipid nanoparticles; trimyristin; flavonoids
Formulasi Busa dari Lateks Cair (Hevea brasiliensis) Asal Kabupaten Musi Rawas Aseptin Murdini, Lia; Nurkayah; Syaifudin
Konservasi Hayati Vol 21 No 2 (2025): OKTOBER
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/hayati.v21i2.45004

Abstract

Musi Rawas is one of the major rubber plantations (Hevea brasiliensis) in South Sumatra. However, prolonged fluctuations and the decline in natural rubber prices have contributed to reduced household income among rubber farmers, affecting their economic stability. This situation highlights the need to enhance the added value of natural rubber products as a strategy to improve farmer welfare and support the achievement of Sustainable Development Goal (SDGs) 1, which aims to alleviate poverty. One promising approach is the utilization of natural rubber latex for foam production through formulation optimization, particularly by adjusting the concentration of zinc-mercaptobenzothiazole (ZMBT), a secondary accelerator known to influence physical properties. This study aimed to evaluate the effect of ZMBT concentrations on the physical properties of natural rubber latex foam. The research was conducted from February to June 2025 at the Integrated Laboratory, Institut Teknologi Muhammadiyah Sumatera, utilizing natural rubber latex sourced from local farmers in Musi Rawas. Three ZMBT concentrations were tested, namely 0.5 phr (A), 1.0 phr (B), and 2.0 phr (C), while all other formulation ingredients were kept constant. The physical properties evaluated included Compression Set (ASTM D395-16e1), Hardness Shore A, Tensile Strength, and Elongation at Break (ASTM D412-16). Based on the results of the research and analysis conducted, it can be concluded that the optimal concentration of ZMBT is at 1 phr, exhibiting physical characteristics including a Compression Set of 86.29%, a Hardness Shore A of 60.05 E.S., a Tensile Strength of 0.1 MPa, and an Elongation at Break of 370%.
Co-Authors Aseptin Murdini, Lia Balqis, Solina Diah Miftahul Aini Elva Febriyanti Lia Aseptin Murdini Mu'awiyatu Al-Laitsi Muhammad Arif Fadilah Syaifudin