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ANTIDIABETIC POTENTIAL OF SOLID LIPID NANOPARTICLES (SLNS) FROM KABAU SEED (ARCHIDENDRON BUBALINUM (JACK) I.C. NIELSEN) EXTRACT COATED WITH TRIMYRISTIN Balqis, Solina; Diah Miftahul Aini; Muhammad Arif Fadilah; Nurkayah; Mu'awiyatu Al-Laitsi; Lia Aseptin Murdini; Elva Febriyanti
ALOTROP Vol. 9 No. 1 (2025): Jurnal Pendidikan dan Ilmu Kimia
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v9i1.42075

Abstract

Type 2 diabetes mellitus is a global health problem that continues to increase. One alternative approach in managing diabetes is using natural materials with antihyperglycemic activity. This study aims to evaluate the effectiveness of solid lipid nanoparticles (SLN) containing Kabau seed extract (Archidendron bubalinum (Jack) I.C. Nielsen) coated with trimyristin in reducing blood glucose levels in hyperglycemic rats. Extraction was carried out by maceration using 96% ethanol, while SLN was synthesized by high-speed homogenization and ultrasonication methods. Particle size analysis showed an average diameter of 262.61 nm with a polydispersity index (PDI) of 0.144, indicating a homogeneous formulation. Phytochemical testing showed that Kabau seed extract contains alkaloids, flavonoids, tannins, and saponins contributing to antihyperglycemic activity. In vivo tests on Mus musculus showed that 20 % concentration of Kabau SLN reduced blood glucose levels by up to 97 mg/dL, approaching the effectiveness of metformin (104 mg/dL). Statistical analysis of ANOVA and BNT test showed significant differences between treatments. These results indicate that Kabau SLN has the potential as a candidate for phytopharmaceuticals in managing type 2 diabetes mellitus. Keywords: Diabetes mellitus; Kabau; solid lipid nanoparticles; trimyristin; flavonoids
Empowering Junior High School Students through Eco-Enzyme Production Training from Fruit Peel Waste: A Community Engagement Program at SMPIT Al-Qudwah, Tugumulyo District: Penelitian Solina Balqis; Elva Febriyanti; Nurkayah; Muhammad Arif Fadillah; Lia Aseptin Murdini; Aldi Fahlefi; Hosiaroba; Viar Refri Zadin
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 3 (2026): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 3 (Januari 202
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i3.4350

Abstract

Organic waste management, particularly fruit peel waste, remains a challenge in school environments. Eco-enzyme production offers a simple and environmentally friendly solution that also supports environmental education. This community service program aimed to improve students’ knowledge and skills in managing fruit peel waste through eco-enzyme production training at SMPIT Al-Qudwah. The program was implemented using a hands-on training approach, including material delivery, direct practice, and evaluation using a pretest–posttest design involving 15 students. The results showed a clear increase in posttest scores compared to pretest scores, indicating improved understanding of organic waste management and eco-enzyme production. The training effectively enhanced students’ environmental awareness and practical skills, demonstrating the potential of experiential learning as a replicable model for school-based environmental education