Putri, Devi Anisya
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Atrophic glossitis and recurrent aphthous stomatitis in patients with anemia and abdominal tuberculosis Putri, Devi Anisya; Laksitasari, Anindita; Pramuditya, Hafizh Zufar; Silva, Ghea De
Journal of Indonesian Dental Association Vol 8 No 1 (2025): May
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v8i1.1208

Abstract

Pendahuluan: Anemia merupakan kondisi penurunan jumlah eritrosit dan kadar hemoglobin, yang dapat disebabkan oleh tuberkulosis (TB) abdomen melalui beberapa mekanisme. Tuberkulosis abdomen disebabkan bakteri Mycobacterium tuberculosis, melibatkan saluran pencernaan, peritoneum, mesenterika, hati, dan limpa. Penderita anemia sering mengalami masalah rongga mulut. Tujuan: Menguraikan manifestasi klinis dan manifestasi oral pada pasien anemia dan TB abdomen. Studi Kasus: Pasien laki-laki berusia 34 tahun dirawat inap di RSUD Margono Soekarjo mengeluhkan perut membesar, kembung, sulit buang angin dan buang air besar sejak 1 bulan. Nafsu makan menurun. Pasien didiagnosis tuberkulosis abdomen dan anemia. Terdapat lesi ulcer pada gingiva bukal rahang atas dan bawah, serta atrofi papilla lidah sehingga pasien didiagnosis stomatitis aftosa rekuren dan atrofik glossitis. Pembahasan: Anemia dapat disebabkan oleh tuberkulosis abdomen melalui perdarahan, gangguan penyerapan nutrisi, dan efek sistemik. Fungsi usus terganggu sehingga menghambat penyerapan nutrisi seperti zat besi dan vitamin B12 yang penting dalam pembentukan eritrosit. Penderita anemia sering mengalami masalah rongga mulut seperti stomatitis dan glossitis. Glossitis yaitu atrofi pada papilla dorsum lidah ditandai sensasi terbakar. Stomatitis aftosa rekuren dapat terjadi karena transportasi oksigen dan nutrisi terganggu sehingga menghambat diferensiasi dan pertumbuhan sel epitel. Kesimpulan: Anemia salah satunya dapat disebabkan oleh tuberkulosis abdomen dan menimbulkan manifestasi pada oral seperti glossitis dan stomatitis aftosa rekuren. Penegakan diagnosis yang baik dapat menentukan pengobatan yang tepat.
The Activities of Torch Ginger Flower (Etlingera elatior) Ethanol Extract on Degradation of Porphyromonas gingivalis Biofilm as Periodontal Pathogen Putri, Devi Anisya; Widodo, A. Haris Budi; Ichsyani, Meylida; Naufalin, Rifda; -, Oedjijono
Journal of Indonesian Dental Association Vol 6 No 1 (2023): April
Publisher : Indonesian Dental Association

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Abstract

Introduction: Porphyromonas gingivalis is bacteria that can form biofilms as the main cause of periodontitis. Mouthwash therapy in long term can cause mucositis and even oral cancer. Antibacterial potential of torch ginger flower (Etlingera elatior) can be developed as an alternative adjuvant therapy for periodontitis. Objective: Aims of this research was to determine the effect of torch ginger flower ethanol extract against degradation of P. gingivalis biofilm. Methods: This research used ethanolic extract of torch ginger flower with concentrations 1.56 mg/mL, 3.125 mg/mL, 6.25 mg/mL, 12.5 mg/mL, 25 mg/mL, and 50 mg/mL. Chlorhexidine gluconate 0.2% was used as positive control and DMSO 1% was used as negative control. Measurement of P. gingivalis biofilm degradation used microtiter plate assay with crystal violet 1% staining which reads its optical density at wavelength of 450 nm. Data were analyzed by one way ANOVA and Post hoc LSD. Results: The percentage of P. gingivalis biofilm degradation with torch ginger flower ethanol extract sequentially were 12.47%, 30.56%, 57.12%, 71.36%, and 74.83%. The analysis showed that there was a significant difference (p<0,05) between treatment groups torch ginger flower ethanol extract, as well as between torch ginger flower ethanol extract with DMSO 1% and chlorhexidine gluconate 0.2%. Optimum concentration of ethanol extract of torch ginger flower on P. gingivalis biofilm degradation was 25 mg/mL and showed no significant difference with chlorhexidine gluconate 0,2% (p>0,05). Conclusion: Conclusion of this research is torch ginger flower (Etlingera elatior) ethanol extract has P. gingivalis biofilm degradation activity.biofilm