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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Skala Kesehatan Academic Hospital Journal
Oktasari, Sholikhah Rosvita
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Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Efektivitas Haloperidol-Difenhidramin sebagai Terapi Agitasi Akut pada Pasien Skizofrenia: Narrative Review Rahmawati, Fita; Medisusyanti, Amalia Suci; Yoga, Bambang Hastha; Oktasari, Sholikhah Rosvita
Jurnal Skala Kesehatan Vol 16 No 2 (2025): Jurnal Skala Kesehatan Edisi Juli 2025
Publisher : Politeknik Kementerian Kesehatan Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/jsk.v16i2.447

Abstract

Schizophrenia psychiatric disorder is characterized by the emergence of delusions, hallucinations, and the inability to distinguish between reality and fantasy. In the acute phase, people with schizophrenia can experience agitation that can endanger themselves and those around them. Rapid-acting antipsychotics with minimal side effects are needed in treating acute agitation in schizophrenia patients. Haloperidol is a first-generation antipsychotic that acts on dopamine D2 receptors, which helps reduce positive and negative symptoms. Haloperidol has been widely used for the treatment of acute agitation because of its rapid effects, but the prevalence of extrapyramidal symptoms is relatively high. Diphenhydramine is an antihistamine with anticholinergic activity used to treat extrapyramidal symptoms. Several guidelines recommend the use of diphenhydramine as a pharmacological therapy for extrapyramidal symptoms, but in practice, psychiatry provides diphenhydramine together with haloperidol as prophylaxis. This combination helps treat acute agitation, where haloperidol can reduce symptoms of schizophrenia, and diphenhydramine can provide sedation and treatment of extrapyramidal symptoms. The challenge in managing acute agitation in schizophrenia patients continues due to drug side effects. A better understanding of the pathophysiology of schizophrenia is expected to produce effective pharmacological therapy alternatives in treating acute agitation
Impact of Pharmacist Counseling Strategy On Adherence And Knowledge of Chronic Kidney Disease Patients: Quasi-Experimental Assessment Filliana, Ulfa -; Oktasari, Sholikhah Rosvita; Molidia, Sri Rahmat; Yasin, Nanang Munif; Kristina, Susi Ari
Academic Hospital Journal Vol 8, No 1 (2026)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v8i1.110980

Abstract

Background: Chronic kidney disease is a progressive condition that requires proper management to slow the decline in kidney function and reduce the risk of complications. Patients with low adherence have an increased risk of kidney progression, and knowledge level plays an important role in the treatment of kidney patients and in collaborative treatment decision-making. This study aims to evaluate the impact of a pharmacist counselling strategy on adherence and knowledge levels in CKD patients.Method: The method was quasi-experimental, with a pretest-posttest design, comparing the intervention and control groups. The intervention was carried out once a week for 1 month, using leaflets as a tool, with inclusion and exclusion criteria, among chronic kidney disease patients during September-October 2023.Result:  The study included 57 patients: 29 in the control group and 28 in the intervention group. The result showed that in the intervention group, there was an increase in knowledge, with a difference between pretest and posttest scores of Δ 8.79±7.802, compared to the control group, which showed a decrease in scores of Δ -0,49±4,932 (p=0.000). Adherence in the intervention group increased by Δ 2,71±1,822 compared to the control group, while adherence in the control group decreased by Δ -0,44±1,152 (p=0.000). A contributing factor to the patient's level of knowledge and compliance was duration of hemodialysis, p=0.032.Conclusion: The conclusion was that the pharmacist counselling strategy significantly improved CKD patient knowledge and medication adherence, and that the duration of hemodialysis significantly contributed to CKD patients' knowledge.
Medication Beliefs and Associated Factors Among Heart Failure Patients in Yemen and Role of Regimen Complexity: a Cross-Sectional Study Abdullah, Ramez; Filliana, Ulfa; Candraningrat, I Dewa Agung Diva; Ridhayani, Firda; Mansoor, Abdullah; Oktasari, Sholikhah Rosvita
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.15222

Abstract

Beliefs about medication influence treatment engagement and outcomes in patients with heart failure, yet evidence from low-resource settings such as Yemen remains limited due to under-supported health care systems and low monitoring in health services. To assess medication beliefs among heart failure patients in Yemen and examine factors associated with necessity and concern beliefs, including medication regimen complexity. A hospital-based cross-sectional study was conducted between December 2023 and February 2024 among heart failure patients attending cardiology outpatient clinics in Sana’a, Yemen after ethical approval from the hospital. Data were collected using structured questionnaires, including the Beliefs About Medication Questionnaire (BMQ-Specific) and the Medication Regimen Complexity Index (MRCI). Multivariable linear regression analyses were performed to identify predictors of medication beliefs. A total of 250 patients were included, with a mean age of 51.08±11.47 years, and 65.2% were male. The median total BMQ score was 38.0 (IQR:35–42). Higher necessity beliefs were independently associated with older age (B=0.046, p=0.029), higher educational status (B=−1.240, p=0.030), and a greater number of prescribed medications (B=0.802, p=0.001), whereas greater medication regimen complexity was negatively associated with necessity beliefs (B=−0.276, p=0.003). Regarding concern beliefs, employment status (B=2.605, p<0.001) and longer duration since diagnosis (>3 years) (B=−1.155, p=0.029) were significant predictors, indicating a mild but significant impact. No significant associations were observed between concern beliefs and age, gender, education, income, number of medications, or regimen complexity. Medication beliefs among heart failure patients in Yemen are shaped by both patient and treatment-related factors. The findings have important implications in clinical practice, both clinical pharmacists and cardiologist can consider patients’ perspective to guide intervention design especially simplifying medication regimens and addressing patient-specific concerns.
Co-Authors Abdullah, Ramez Candraningrat, I Dewa Agung Diva Filliana, Ulfa Filliana, Ulfa - Firda Ridhayani Fita Rahmawati Mansoor, Abdullah Medisusyanti, Amalia Suci Molidia, Sri Rahmat Nanang Munif Yasin Susi Ari Kristina Yoga, Bambang Hastha