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All Journal The Indonesian Biomedical Journal Jurnal Ilmiah Kesehatan
Junnata, Agung
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Biochemistry, Genetics & Molecular Biology Health Professions Nursing Public Health

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APOA2–265 T>C Polymorphism as A Genetic Marker Associated with Lipid Profiles and Cardiovascular Risk in A Healthy Indonesian Population Hartanti, Monica Dwi; Hizbulloh, Ilham; Satibi, Janice Puteri; Virgo, Ricardo Lie; Anastasya, Karina Shasri; Adli, Mizanul; Amarendra, Gerie; Junnata, Agung
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3472

Abstract

BACKGROUND: Apolipoprotein A (APOA)2–265 T>C polymorphism significantly affects lipid metabolism and body composition, as well as plays a key role in cardiovascular diseases (CVD) and metabolic syndrome. In this study, association between the APOA2 polymorphism, lipid profiles, body composition, and cardiovascular disease (CVD) risk in a healthy Indonesian population was investigated. Although similar studies have been conducted in other populations, this study addresses the urgent need to understand genetic factors influencing lipid profiles in Southeast and East Asia, where hypercholesterolemia rate keep rising, particularly in Indonesia.METHODS: A cross-sectional study involving 84 healthy participants was performed. Genotyping for the APOA2–265 T>C polymorphism was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Plasma levels of APOA2 and APOB100 were measured with enzyme-linked immunosorbent assay (ELISA), and APOB100/APOA2 ratio was calculated to assess CVD risk. Lipid profiles were evaluated with enzymatic methods, and body fat percentage was measured using calipers.RESULTS: CT/CC genotypes showed significantly lower plasma APOA2 levels compared to the TT genotype (p=0.0215). APOB100/APOA2 ratio was significantly higher in CT/CC genotypes (p=0.0020) and remained significant after Bonferroni correction. No significant differences were found in lipid profiles and body fat percentages between genotypes after correction, although trends suggested higher cholesterol and low-density lipoprotein (LDL) levels in TT genotypes and higher median body fat percentages in CC/CT genotypes.CONCLUSION: APOA2–265 T>C polymorphism is linked to changes in lipid profiles and body composition, potentially raising CVD risk in CT/CC genotypes. However, limited sample size and modest effect sizes suggest that the practical use of APOA2 genotyping for risk assessment might require further investigation.KEYWORDS: APOA2 polymorphism, APOB100, hypercholesterolemia, cardiovascular disease, lipid profile, body fat percentage
Analisis Perencanaan Transformasi Manajemen Logistik Pada Radjak Hospital Salemba Junnata, Agung; Zerlinda, Davina Puspa; Pradewa, Firstandika Aria; Chudri, Juni; Suwignyo; Muhammad Jauharil Wafi
Jurnal Ilmiah Kesehatan Vol 17 No 2 (2025): Jurnal Ilmiah Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/jik.v17i2.2598

Abstract

Instalansi Farmasi Rumah Sakit (IFRS) berperan penting dalam pengelolaan obat di rumah sakit, yang mencakup berbagai proses seperti perencanaan, pengadaan, penerimaan, penyimpanan, pendistribusian, pemusnahan, dan retur barang. Proses pengadaan logistik dibedakan menjadi dua sistem, yaitu sentralisasi dan desentralisasi. Saat ini, Radjak Hospital Salemba menerapkan sistem desentralisasi dalam perencanaan dan pengadaan obat, tetapi berencana untuk beralih ke sistem sentralisasi. Tujuan dari perubahan ini adalah untuk meningkatkan efisiensi dalam pembelian obat dan mengurangi biaya pengeluaran. Penelitian ini bertujuan untuk mengevaluasi efektivitas dan efisiensi antara sistem logistik sentralisasi dan desentralisasi dalam pengelolaan obat di Radjak Hospital Salemba. Metodologi yang digunakan adalah deskriptif kualitatif dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa IFRS telah mencapai tahap pembentukan Perusahaan Besar Farmasi (PBF), di mana semua pembelian obat akan dilakukan melalui satu PBF. Saat ini, IFRS Radjak Hospital Salemba sudah menerapkan sistem manajemen logistik dengan cukup baik yang menggunakan sistem desentralisasi dengan banyak vendor untuk pengadaan obat.
Co-Authors Adli, Mizanul Anastasya, Karina Shasri Gerie Amarendra Hizbulloh, Ilham Juni Chudri Monica Dwi Hartanti, Monica Dwi Muhammad Jauharil Wafi Pradewa, Firstandika Aria Satibi, Janice Puteri Suwignyo Virgo, Ricardo Lie Zerlinda, Davina Puspa