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All Journal Hydrogen: Jurnal Kependidikan Kimia CHEDS: Journal of Chemistry, Education, and Science
Islami, Agustina Amalia
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Biochemistry, Genetics & Molecular Biology Chemistry Education Materials Science & Nanotechnology

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KAJIAN LITERATUR : PROJECT BASED LEARNING (PjBL) PADA PEMBELAJARAN KIMIA DALAM MENINGKATKAN HASIL BELAJAR Simangunsong, Ari Putra Wijaya; Islami, Agustina Amalia; Asiyah, Mely Nor; Ridwansyah, Muhammad; Rahmadani, Agung
CHEDS: Journal of Chemistry, Education, and Science Vol 8, No 2 (2024)
Publisher : Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/cheds.v8i2.10182

Abstract

Pembelajaran berbasis proyek (PjBL) merupakan model pembelajaran yang melibatkan peran aktif peserta didik. Pembelajaran berbasis proyek memberikan peserta didik untuk berpartisipasi dalam kegiatan pembelajaran dan membantu memperoleh pengetahuan dan wawasan baru berdasarkan makna pembelajaran yang diperoleh dengan tujuan pembelajaran berbasis proyek dalam meningkatkan hasil belajar peserta didik dan meningkatkan keaktifan dan kerjasama dalam pembelajaran. untuk mengeksplorasi dan memperdalam pelajaran dengan menyelidiki isu-isu dan pertanyaan yang relevan dan penting. Tinjauan pustaka ini menggunakan tinjauan pustaka naratif. Pembelajaran berbasis proyek (PjBL) dalam pembelajaran kimia merupakan pembelajaran dimana siswa dapat belajar dengan mengerjakan suatu proyek dengan kemampuan dan pemahaman siswa terkait konsep dan materi kimia untuk melihat hasil belajar yang maksimal dalam proses pembelajaran.
Synthesis and In Silico Study of 5’-Chloro-2’,4-Dihydroxy-3-Methoxychalcone as Potential Inhibitors of Estrogen Receptors Alpha Putri, Rizka Amalia; Nurramadhani, Aisyah Zahra; Islami, Agustina Amalia; Tristania, Auriel Wafiq; Aulia, Isma; Farah, Harra Ismi; Arifian, Hanggara; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 2 (2025): April 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i2.15546

Abstract

The high prevalence of breast cancer necessitates the discovery of new, more effective, and safer anticancer compounds. Chalcone, a flavonoid with promising anticancer activity, is limited by poor bioavailability and rare natural occurrence. In this study, a novel chalcone derivative, 5'-chloro-2',4-dihydroxy-3-methoxychalcone, was synthesized on a laboratory scale via Claisen-Schmidt condensation using 5-chloro-2-hydroxyacetophenone and 4-hydroxy-3-methoxybenzaldehyde as starting materials. The structure of the synthesized compound was confirmed by mass spectrometry and NMR analysis. Pharmacokinetic and toxicity profiles were predicted in silico using SwissADME, while molecular docking simulations with the ERα receptor were performed using AutoDockTools. The compound was obtained as a yellow solid with a yield of 70.15%, showed favorable ADME properties based on Lipinski’s and Veber’s rules, and demonstrated a binding energy of -7.82 kcal/mol to the ERα receptor, indicating potential as an anticancer agent. The novelty of this research is the successfully synthesized and characterized of this specific chalcone, which is structurally different from previously reported analogs. These findings enrich the diversity of chalcone derivatives and provide a new basis for developing synthesis-based drug candidates targeting breast cancer.
Co-Authors Arifian, Hanggara Asiyah, Mely Nor Aulia, Isma Farah, Harra Ismi Muhammad Ridwansyah Nurramadhani, Aisyah Zahra Putri, Rizka Amalia Rahmadani, Agung Simangunsong, Ari Putra Wijaya Tristania, Auriel Wafiq