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All Journal Jambura Journal of Educational Chemistry Hydrogen: Jurnal Kependidikan Kimia CHEDS: Journal of Chemistry, Education, and Science
Islami, Agustina Amalia
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Biochemistry, Genetics & Molecular Biology Chemistry Education Materials Science & Nanotechnology Other

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KAJIAN LITERATUR : PROJECT BASED LEARNING (PjBL) PADA PEMBELAJARAN KIMIA DALAM MENINGKATKAN HASIL BELAJAR Simangunsong, Ari Putra Wijaya; Islami, Agustina Amalia; Asiyah, Mely Nor; Ridwansyah, Muhammad; Rahmadani, Agung
CHEDS: Journal of Chemistry, Education, and Science Vol 8, No 2 (2024)
Publisher : Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/cheds.v8i2.10182

Abstract

Pembelajaran berbasis proyek (PjBL) merupakan model pembelajaran yang melibatkan peran aktif peserta didik. Pembelajaran berbasis proyek memberikan peserta didik untuk berpartisipasi dalam kegiatan pembelajaran dan membantu memperoleh pengetahuan dan wawasan baru berdasarkan makna pembelajaran yang diperoleh dengan tujuan pembelajaran berbasis proyek dalam meningkatkan hasil belajar peserta didik dan meningkatkan keaktifan dan kerjasama dalam pembelajaran. untuk mengeksplorasi dan memperdalam pelajaran dengan menyelidiki isu-isu dan pertanyaan yang relevan dan penting. Tinjauan pustaka ini menggunakan tinjauan pustaka naratif. Pembelajaran berbasis proyek (PjBL) dalam pembelajaran kimia merupakan pembelajaran dimana siswa dapat belajar dengan mengerjakan suatu proyek dengan kemampuan dan pemahaman siswa terkait konsep dan materi kimia untuk melihat hasil belajar yang maksimal dalam proses pembelajaran.
Synthesis and In Silico Study of 5’-Chloro-2’,4-Dihydroxy-3-Methoxychalcone as Potential Inhibitors of Estrogen Receptors Alpha Putri, Rizka Amalia; Nurramadhani, Aisyah Zahra; Islami, Agustina Amalia; Tristania, Auriel Wafiq; Aulia, Isma; Farah, Harra Ismi; Arifian, Hanggara; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 2 (2025): April 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i2.15546

Abstract

The high prevalence of breast cancer necessitates the discovery of new, more effective, and safer anticancer compounds. Chalcone, a flavonoid with promising anticancer activity, is limited by poor bioavailability and rare natural occurrence. In this study, a novel chalcone derivative, 5'-chloro-2',4-dihydroxy-3-methoxychalcone, was synthesized on a laboratory scale via Claisen-Schmidt condensation using 5-chloro-2-hydroxyacetophenone and 4-hydroxy-3-methoxybenzaldehyde as starting materials. The structure of the synthesized compound was confirmed by mass spectrometry and NMR analysis. Pharmacokinetic and toxicity profiles were predicted in silico using SwissADME, while molecular docking simulations with the ERα receptor were performed using AutoDockTools. The compound was obtained as a yellow solid with a yield of 70.15%, showed favorable ADME properties based on Lipinski’s and Veber’s rules, and demonstrated a binding energy of -7.82 kcal/mol to the ERα receptor, indicating potential as an anticancer agent. The novelty of this research is the successfully synthesized and characterized of this specific chalcone, which is structurally different from previously reported analogs. These findings enrich the diversity of chalcone derivatives and provide a new basis for developing synthesis-based drug candidates targeting breast cancer.
Development of Learning Videos on the Atomic Model Concepts Based on Multilevel Representation Islami, Agustina Amalia; Gunawan, Rony; Erika, Farah; Rahmadani, Agung; Sukemi, Sukemi
Jambura Journal of Educational Chemistry Vol 8, No 1 (2026): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjec.v8i1.36535

Abstract

This study was motivated by difficulties in learning complex and abstract concepts in atomic model development, while commonly used learning videos still provide limited representation, reducing students’ ability to connect concepts with real phenomena. This study aims to develop a multilevel representation-based learning video on atomic model development and to examine its validity, practicality, and effectiveness using a research and development approach involving planning, production, and evaluation stages. The subjects in this study included 2 media experts, 2 material experts, 1 chemistry teacher, and 60 tenth-grade students from classes X-5 and X-6 at SMAN 14 Samarinda. Product validity was assessed by experts, practicality was measured through teacher and student questionnaires and activity observations, and effectiveness was analyzed by comparing pretest and posttest results quantitatively. The results show very high validity, with material expert validation reaching 100% and an average media expert score of 99.25%. Teacher practicality was categorized as very practical, with questionnaire and observation scores of 96.67% and 98.33%, while student practicality scores reached 82% and 81.7%, categorized as practical. The effectiveness of the media was demonstrated by an N-gain value of 0.56 (moderate) and an effect size of 4.94 (very strong), supported by positive student responses with ease of understanding scoring of 82.17% and learning interest of 86.33% (excellent category), while learning activity (79.66%) and media practicality and features (79.83%) fell into the good category. These findings confirm that multilevel representation-based learning videos effectively enhance students’ understanding of atomic model development.
Co-Authors Arifian, Hanggara Asiyah, Mely Nor Aulia, Isma Farah Erika Farah, Harra Ismi Gunawan, Rony Muhammad Ridwansyah Nurramadhani, Aisyah Zahra Putri, Rizka Amalia Rahmadani, Agung Simangunsong, Ari Putra Wijaya Sukemi Sukemi Tristania, Auriel Wafiq