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All Journal Hydrogen: Jurnal Kependidikan Kimia
Nurramadhani, Aisyah Zahra
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Chemistry Education

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Literature Review: Universal Design for Learning (UDL) Approach of Chemistry Learning in Inclusion Schools Nurramadhani, Aisyah Zahra; Pratama, Kiki Putri Septya; Amelia, Lisa; Kusuma, Aldi; Erika, Farah
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 6 (2024): December 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i6.13636

Abstract

Inclusive education is a promising way to create an equitable and high-quality education system that accepts all learners, including those with special needs. Universal Design for Learning (UDL) offers a flexible and dynamic approach to meet the various needs of learners, helping them to reach their full potential in education. This literature study aims to discover the application of the universal design for learning approach in chemistry learning. The research method used Narrative Literature Review (NLR), which uses the Google Scholar database to search for journal articles from the last ten years. The results of the literature show that applying the Universal Design for Learning approach in chemistry learning has a major influence in improving the learning experience and learning outcomes of students with special needs. Various interesting teaching materials such as learning videos, interactive games, and the application of E-modules are also used to support the learning process.
Literature Review: Universal Design for Learning (UDL) Approach of Chemistry Learning in Inclusion Schools Nurramadhani, Aisyah Zahra; Pratama, Kiki Putri Septya; Amelia, Lisa; Kusuma, Aldi; Erika, Farah
Hydrogen: Jurnal Kependidikan Kimia Vol. 12 No. 6 (2024): December 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i6.13636

Abstract

Inclusive education is a promising way to create an equitable and high-quality education system that accepts all learners, including those with special needs. Universal Design for Learning (UDL) offers a flexible and dynamic approach to meet the various needs of learners, helping them to reach their full potential in education. This literature study aims to discover the application of the universal design for learning approach in chemistry learning. The research method used Narrative Literature Review (NLR), which uses the Google Scholar database to search for journal articles from the last ten years. The results of the literature show that applying the Universal Design for Learning approach in chemistry learning has a major influence in improving the learning experience and learning outcomes of students with special needs. Various interesting teaching materials such as learning videos, interactive games, and the application of E-modules are also used to support the learning process.
Synthesis and In Silico Study of 5’-Chloro-2’,4-Dihydroxy-3-Methoxychalcone as Potential Inhibitors of Estrogen Receptors Alpha Putri, Rizka Amalia; Nurramadhani, Aisyah Zahra; Islami, Agustina Amalia; Tristania, Auriel Wafiq; Aulia, Isma; Farah, Harra Ismi; Arifian, Hanggara; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 2 (2025): April 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i2.15546

Abstract

The high prevalence of breast cancer necessitates the discovery of new, more effective, and safer anticancer compounds. Chalcone, a flavonoid with promising anticancer activity, is limited by poor bioavailability and rare natural occurrence. In this study, a novel chalcone derivative, 5'-chloro-2',4-dihydroxy-3-methoxychalcone, was synthesized on a laboratory scale via Claisen-Schmidt condensation using 5-chloro-2-hydroxyacetophenone and 4-hydroxy-3-methoxybenzaldehyde as starting materials. The structure of the synthesized compound was confirmed by mass spectrometry and NMR analysis. Pharmacokinetic and toxicity profiles were predicted in silico using SwissADME, while molecular docking simulations with the ERα receptor were performed using AutoDockTools. The compound was obtained as a yellow solid with a yield of 70.15%, showed favorable ADME properties based on Lipinski’s and Veber’s rules, and demonstrated a binding energy of -7.82 kcal/mol to the ERα receptor, indicating potential as an anticancer agent. The novelty of this research is the successfully synthesized and characterized of this specific chalcone, which is structurally different from previously reported analogs. These findings enrich the diversity of chalcone derivatives and provide a new basis for developing synthesis-based drug candidates targeting breast cancer.
Literature Review: Alkaloid Compounds in Medicinal Plants: Mechanisms and Anti-Diabetic Potential Rahmadhani, Ade Novira; Rismawati, Lia; Nurramadhani, Aisyah Zahra; Syahputri, Salsabila Dia; Saputri, Rindiani Dwi; Usman, Usman
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 3 (2025): June 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i3.16012

Abstract

Alkaloids are a group of chemical compounds found in nature with the most basic nitrogen atoms. As many as 20% of plant species contain alkaloid compounds, one of which is flowering plants. Plants that contain alkaloid compounds have the potential to be antidiabetic agents. This literature review research uses the narrative literature review method. Using keywords from the range of 2014-2024, a total of 25 articles were obtained. Diabetes is a common metabolic disease caused by insulin deficiency. The plants that contain bioactive alkaloid compounds are Catharanthus roseus, Portulaca oleracea L. (PO), Momordica charantia (Bitter Melon), Uncaria Nervosa Elmer (Bajakah), Peperomia Pelucida (Water Pepper), Mulberry, Ageratum conyzoides L (Ageratum), Syzygium sp (Red Pakoba Fruit), Sansevieria trifasciata (Mother-in-law's Tongue), Triumfetta cordifolia, Phrynium Capitatum (Rice Leaf), and Annona Muricata L. (Soursop Leaf), which have been proven to contain alkaloid activity compounds that can be used as anti-diabetic agents. Alkaloid compounds play an essential role in diabetes management through various mechanisms that regulate blood glucose levels.
Co-Authors Arifian, Hanggara Aulia, Isma Farah Erika Farah, Harra Ismi Islami, Agustina Amalia Kusuma, Aldi Lisa Amelia Pratama, Kiki Putri Septya Putri, Rizka Amalia Rahmadani, Agung Rahmadhani, Ade Novira Rismawati, Lia Saputri, Rindiani Dwi Syahputri, Salsabila Dia Tristania, Auriel Wafiq Usman Usman