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All Journal JCRS (Journal of Community Research and Service) Hydrogen: Jurnal Kependidikan Kimia Jurnal Pengabdian Masyarakat (ABDIRA)
Farah, Harra Ismi
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Aerospace Engineering Chemistry Computer Science & IT Education Languange, Linguistic, Communication & Media Nursing Social Sciences Other

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Pembuatan Simplisia Rimpang-rimpangan dan Dorongan Pembentukan Ukot Umot pada Kelompok Tani Desa Lempake Samarinda Sulistiarini, Riski; Nisaa, Nur Rezky Khairun; Farah, Harra Ismi; Arifian, Hanggara; Meylina, Lisna; Rijai, Akhmad Jaizzur; Prasesti, Gayuk Kalih
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 5, No 1 (2025): Abdira, Januari
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v5i1.568

Abstract

The community service activity themed "Preparation of Rhizome Simplisia and Encouragement for the Formation of Ukot Umot in the Farmer Group of Lempake Village, Samarinda" aimed to increase public knowledge about the preparation of high-quality rhizome simplisia and to encourage the establishment of local institution-based organizations (Ukot Umot). The activity involved farmer groups, women's PKK groups, and village officials. The materials presented included stages of washing, cutting, drying, and storing simplisia. Additionally, a participatory discussion on the importance of Ukot Umot institutions was conducted to strengthen collaboration and improve market access. Based on an evaluation through a questionnaire, 100% of participants stated that the activity was highly beneficial, with high satisfaction levels regarding the relevance of the material, the delivery method, and the benefits of the activity. The initial impacts of the activity included increased participant knowledge, a commitment to forming Ukot Umot, and motivation to process rhizomes independently. Despite challenges such as limited facilities, this activity successfully laid the foundation for the sustainable development of rhizome-based businesses.
Workshop Pembuatan Gummy Candy Madu Kelulut Di Desa Bangun Rejo Kabupaten Kutai Kartanegara Samsul, Erwin; Junaidin, Junaidin; Rijai, Laode; Ibrahim, Arsyik; Herman, Herman; Rusli, Rolan; Ahmad, Islamudin; Febrina, Lizma; Farah, Harra Ismi; Hikmawan, Baso Didik; Rija’i, Hifdzur Rashif; Supriatno, Supriatno; Rusman, Arman; Almeida, Maria; Riki, Riki; Arifuddin, M; Bone, Mahfuzun; Arifian, Hanggara; Setiawaty, Agus
Journal of Community Research and Service Vol. 9 No. 2: July (2025)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jcrs.v9i2.69839

Abstract

A workshop on making gummy candy based on stingless bee honey was held in Bangun Rejo Village, Kutai Kartanegara Regency, as an effort to empower the community through innovation in locally processed food products. The aim of this activity was to improve the skills of MSME actors and village residents in producing stingless honey gummy candy, and to elevate the added value of local honey. The methods used included a short theoretical session about the composition of stingless bee honey and the technical process of gummy candy production, a live demonstration, group practice among participants, as well as evaluation via pre-test and post-test on understanding and skills. The workshop was attended by 50 participants from various MSMEs and community groups. Results showed that after training there was an increase in participant understanding by approximately 75% compared to before the training. Furthermore, participants succeeded in making gummy candy with a chewy texture, the natural sweetness of stingless bee honey, and a distinctive aroma that was well accepted in organoleptic tests. This workshop made a tangible contribution to local product diversification, increasing production capacity, and the potential enhancement of village income through signature products based on stingless bee.
Synthesis and In Silico Study of 5’-Chloro-2’,4-Dihydroxy-3-Methoxychalcone as Potential Inhibitors of Estrogen Receptors Alpha Putri, Rizka Amalia; Nurramadhani, Aisyah Zahra; Islami, Agustina Amalia; Tristania, Auriel Wafiq; Aulia, Isma; Farah, Harra Ismi; Arifian, Hanggara; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 2 (2025): April 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i2.15546

Abstract

The high prevalence of breast cancer necessitates the discovery of new, more effective, and safer anticancer compounds. Chalcone, a flavonoid with promising anticancer activity, is limited by poor bioavailability and rare natural occurrence. In this study, a novel chalcone derivative, 5'-chloro-2',4-dihydroxy-3-methoxychalcone, was synthesized on a laboratory scale via Claisen-Schmidt condensation using 5-chloro-2-hydroxyacetophenone and 4-hydroxy-3-methoxybenzaldehyde as starting materials. The structure of the synthesized compound was confirmed by mass spectrometry and NMR analysis. Pharmacokinetic and toxicity profiles were predicted in silico using SwissADME, while molecular docking simulations with the ERα receptor were performed using AutoDockTools. The compound was obtained as a yellow solid with a yield of 70.15%, showed favorable ADME properties based on Lipinski’s and Veber’s rules, and demonstrated a binding energy of -7.82 kcal/mol to the ERα receptor, indicating potential as an anticancer agent. The novelty of this research is the successfully synthesized and characterized of this specific chalcone, which is structurally different from previously reported analogs. These findings enrich the diversity of chalcone derivatives and provide a new basis for developing synthesis-based drug candidates targeting breast cancer.
Toxicity and Antioxidant Activity Test of Rambutan Seeds (Nephelium lappaceum L.) Arum, Alvionita Puspa; Rahmadani, Agung; Rijai, Laode; Farah, Harra Ismi
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 3 (2025): June 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i3.16376

Abstract

Rambutan (Nephelium lappaceum L.) seeds have long been utilized in traditional medicine due to their potential therapeutic properties. This study aimed to determine the secondary metabolite profile, toxicity, and antioxidant activity of the methanolic extract and ethyl acetate fraction of rambutan seeds to strengthen their potential application in traditional medicine. The powdered of rambutan seed was extracted with a maceration technique using methanol, followed by fractionation using n-hexane and ethyl acetate. The methanol extract and ethyl acetate fraction were tested for toxicity using the Brine Shrimp Lethality Test (BSLT) and for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Phytochemical screening was performed using standard qualitative method to identify secondary metabolites, which confirmed the presence of phenols, tannins, and flavonoids in both samples. Toxicity testing indicated LCâ‚…â‚€ values of 688.86 ppm for the methanol extract and 825.68 ppm for the ethyl acetate fraction. Antioxidant activity assessment revealed ICâ‚…â‚€ values of 328.61 ppm for the methanol extract and the higher activity for ethyl acetate fraction of 32.78 ppm. These results indicate that the ethyl acetate fraction of rambutan seeds may serve as a promising natural source of antioxidants for therapeutic development.
Co-Authors Agus Setiawaty Almeida, Maria Arifian, Hanggara Arifuddin, M Arum, Alvionita Puspa Aulia, Isma Bone, Mahfuzun Daniel Happy Putra Febrina, Lizma Hikmawan, Baso Didik Ibrahim, Arsyik Islami, Agustina Amalia Islamudin Ahmad Junaidin, Junaidin Laode Rijai Meylina, Lisna Nisaa, Nur Rezky Khairun Nurramadhani, Aisyah Zahra Prasesti, Gayuk Kalih Putri, Rizka Amalia Rahmadani, Agung Rijai, Akhmad Jaizzur Rija’i, Hifdzur Rashif RIKI RIKI, RIKI Rusli, Rolan Rusman, Arman Samsul, Erwin Sulistiarini, Riski Supriatno Tristania, Auriel Wafiq