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All Journal Hydrogen: Jurnal Kependidikan Kimia Arfak Chem: Chemistry Education Journal
Tristania, Auriel Wafiq
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Humanities Chemistry Education Social Sciences

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Kajian Literatur Penerapan Kimia Hijau dan Tujuan Pembangunan Berkelanjutan dalam Pembelajaran Kimia Anggraeni, Egi Syahrah; Putri, Rizka Amalia; Tristania, Auriel Wafiq; Maharani, Tiara; Wirhanuddin, Wirhanuddin; Rahmadani, Agung
Arfak Chem: Chemistry Education Journal Vol. 7 No. 2 (2024): Arfak Chem
Publisher : Universitas Papua, Manokwari, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/accej.v7i2.739

Abstract

Penerapan konsep kimia hijau dan tujuan pembangunan berkelanjutan (Sustainable Development Goals) dalam pembelajaran kimia menjadi sangat penting untuk menghadapi tantangan global saat ini, seperti pemanasan global dan kerusakan lingkungan. Kajian literatur ini bertujuan untuk mengeksplorasi prinsip-prinsip kimia hijau yang dapat diintegrasikan ke dalam kurikulum pendidikan, sehingga meningkatkan pemahaman siswa tentang dampak kimia terhadap keberlanjutan. Metode yang digunakan dalam kajian ini adalah narrative literature review yang mengumpulkan dan menganalisis berbagai sumber literatur terkait penerapan kimia hijau dan SDGs dalam pendidikan. Hasil kajian menunjukkan bahwa integrasi prinsip-prinsip keberlanjutan dalam pembelajaran kimia tidak hanya mendorong praktik pendidikan yang inovatif dan interdisipliner, tetapi juga memungkinkan pendidik dan peserta didik untuk berkontribusi secara aktif dalam menciptakan solusi berkelanjutan. Dengan demikian, pengembangan kurikulum yang relevan sangat diperlukan untuk memastikan generasi mendatang lebih sadar akan isu-isu keberlanjutan.
Synthesis and In Silico Study of 5’-Chloro-2’,4-Dihydroxy-3-Methoxychalcone as Potential Inhibitors of Estrogen Receptors Alpha Putri, Rizka Amalia; Nurramadhani, Aisyah Zahra; Islami, Agustina Amalia; Tristania, Auriel Wafiq; Aulia, Isma; Farah, Harra Ismi; Arifian, Hanggara; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 2 (2025): April 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i2.15546

Abstract

The high prevalence of breast cancer necessitates the discovery of new, more effective, and safer anticancer compounds. Chalcone, a flavonoid with promising anticancer activity, is limited by poor bioavailability and rare natural occurrence. In this study, a novel chalcone derivative, 5'-chloro-2',4-dihydroxy-3-methoxychalcone, was synthesized on a laboratory scale via Claisen-Schmidt condensation using 5-chloro-2-hydroxyacetophenone and 4-hydroxy-3-methoxybenzaldehyde as starting materials. The structure of the synthesized compound was confirmed by mass spectrometry and NMR analysis. Pharmacokinetic and toxicity profiles were predicted in silico using SwissADME, while molecular docking simulations with the ERα receptor were performed using AutoDockTools. The compound was obtained as a yellow solid with a yield of 70.15%, showed favorable ADME properties based on Lipinski’s and Veber’s rules, and demonstrated a binding energy of -7.82 kcal/mol to the ERα receptor, indicating potential as an anticancer agent. The novelty of this research is the successfully synthesized and characterized of this specific chalcone, which is structurally different from previously reported analogs. These findings enrich the diversity of chalcone derivatives and provide a new basis for developing synthesis-based drug candidates targeting breast cancer.
Co-Authors Anggraeni, Egi Syahrah Arifian, Hanggara Aulia, Isma Farah, Harra Ismi Islami, Agustina Amalia Nurramadhani, Aisyah Zahra Putri, Rizka Amalia Rahmadani, Agung Tiara Maharani, Tiara Wirhanuddin, Wirhanuddin