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Azmi, Sabrina
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Atypical Glandular Cell Suggestive of Adenocarcinoma In Situ on Pap Smear Examination Hamidiyah, Silpi; Azmi, Sabrina
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47455

Abstract

Introduction: Atypical Glandular Cells (AGC) on Pap smear is a finding that requires further evaluation, as it may indicate precancerous lesions such as adenocarcinoma in situ (AIS) or invasive adenocarcinoma. This case discusses a 45-year-old woman with postcoital spotting, diagnosed with AGC suggesting AIS and a focus of adenocarcinoma. Case Report: The patient presented to the clinic with postcoital spotting over the past two weeks. Cervical examination revealed a mass on the cervix from the 11 o’clock to 4 o’clock position. A Pap smear revealed AGC suggesting AIS. The patient subsequently underwent colposcopy and biopsy, which confirmed adenocarcinoma in situ with a focus of invasive adenocarcinoma. Discussion: Atypical Glandular Cells on Pap smear carry a significant risk of cervical neoplasia. Further evaluation with colposcopy and biopsy is crucial for accurate diagnosis. In this case, the finding of adenocarcinoma in situ with a focus of invasive adenocarcinoma highlights the need for aggressive management, such as hysterectomy, to prevent progression to fully invasive cervical cancer. Management with radical hysterectomy was recommended to prevent further progression to invasive cancer. This procedure aimed to remove the lesion completely and prevent recurrence. Conclusion: Detection of AGC suggesting AIS requires immediate investigation for proper diagnosis and management. Radical hysterectomy may be an effective treatment option to prevent further progression and improve the patient's prognosis. Keywords: AGC, AIS, pap smear.
Menyerupai Kanker, Mengungkap Amuba: Kasus Langka Abses Hati Amubik yang Terbukti melalui Biopsi Azmi, Sabrina; Hamidiyah, Silpi; Ningsih, Pangisti Dwi Ana
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.51063

Abstract

Abses hati amuba disebabkan oleh parasit Entamoeba histolityca dan menjadi masalah yang signifikan di Indonesia, hingga menyebabkan 50000 kematian di dunia. Gejala penyakit ini dapat berupa demam, nyeri perut dan pembesaran organ hepar. Dengan dilakukannya penegakkan diagnosis yang tepat, salah satunya adalah dengan menemukan parasit di jaringan hati yang terinfeksi, maka diharapkan angka kematian akibat AHA dapat berkurang. Tujuan dari penelitian ini adalah untuk melaporkan kasus mengenai Wanita 58 tahun dengan keluhan nyeri perut kanan atas sejak ± 3 minggu, disertai dengan perut terasa sebah, mual, dan penurunan nafsu makan. Metode yang digunakan adalah analisis gejala klinis dan pemeriksaan penunjang laboratorium dan biopsi histopatologi dengan pewarnaan HE. Pemeriksaan laboratorium menunjukkan peningkatan leukosit (21.600) dengan NLR > 10 9, hipalbuminemia (2,4 g/dL), CRP meningkat (16,03), dan rasio R sebesar 0,32. USG abdomen mengungkapkan adanya massa padat dengan bagian kistik di lobus kiri hepar berukuran 10,7 x 7,56 x 11,1 cm dengan dugaan abses atau hepatoma. Hasil biopsi hepar menunjukkan adanya area nekrotik yang luas dengan infiltrasi sel radang, dominan neutrofil, limfosit, dan makrofag, serta ditemukan struktur menyerupai amuba yang sebagian mengAHAmi lisis degeneratif. Kesimpulan, pasien didiagnosis dengan abses hepar amubik berdasarkan gambaran klinis, pemeriksaan penunjang, dan hasil biopsi histopatologis.
Nicotine reduces cell viability and induces oxidative stress in human gingival fibroblasts Azmi, Sabrina; Hadi, Restu Syamsul; Kusuma, Indra; Suciati, Yulia; Sari, Wening
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.20-30

Abstract

BackgroundNicotine, as the main component of cigarettes, is known to interfere with the proliferation of human gingival fibroblasts (HGFs) and can trigger oxidative stress. This study aimed to analyze the impact of nicotine on viability, expression of the antioxidant Nrf2, levels of the product of oxidative stress malondialdehyde (MDA), and the migration capacity of HGFs. MethodsAn experimental laboratory study used fibroblasts isolated from healthy human gingiva. The cells were grouped into the non-treatment control group (NTC), the solvent control (SC), and the treatment groups, exposed to nicotine at various concentrations for twenty-four hours. Cell viability was assesed using the cell counting kit-8 (CCK-8), Nrf2 expression was examined using ELISA, MDA level was measured using an MDA kit, and migration capacity was assessed using a scratch assay. Statistical analysis used one-way Anova or Kruskal-Wallis test. A p-value of <0.05 was expressed statistically significant. ResultsThe Cell viability was substantially reduced in the nicotine group compared to the untreated group, accompanied by changes in cell morphology. In contrast, Nrf2 expression increased significantly (p=0.010) in the 5 mM nicotine group compared with the control group. The MDA levels were not significantly distinct across groups (p=0.056). Cell migration was delayed significantly in the 5 mM nicotine group at 72 hours after scratching compared to the control group. ConclusionNicotine decreased HGFs viability and increased Nrf2 expression significantly in a dose-dependent manner. Nicotine at 5 mM concentration did not alter MDA levels but delayed cell migration.
Co-Authors Hamidiyah, Silpi Indra Kusuma Ningsih, Pangisti Dwi Ana Restu Syamsul Hadi Wening Sari Yulia Suciati