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All Journal CHEMPUBLISH JOURNAL Makara Journal of Science
Shadrina, Putri Nur
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Synthesis of Carboxymethyl Cellulose from Nypa fruticans for Coating Metformin on Zn-Based Metal-Organic Framework Nanohybrid as a Bionanocomposite Drug Delivery System Delviani, Delviani; Maharani, Viola Giary Rizkillah; Shadrina, Putri Nur; Warni, Tri; Azizah, Regina Wan; Tarigan, Indra Lasmana; Latief, Madyawati
Makara Journal of Science Vol. 29, No. 2
Publisher : UI Scholars Hub

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Abstract

Diabetes is a common and rapidly spreading disease that affects 6.6% of the world’s population. Metformin hydrochloride (HCl) is an effective oral pharmacological treatment for type 2 diabetes mellitus (T2DM) patients because of its capability to reduce glucose levels and the risk of hypoglycaemia. However, gastrointestinal sensitivities to this drug can cause diarrhoea, nausea, vomiting and stomach ache. An alternative is controlled release technology by coating metformin with carboxymethyl cellulose (CMC) and zinc-metal-organic framework (Zn-MOF) through the encapsulation method. Therefore, this study aimed to coat metformin formulations using CMC in a Zn-MOF to control release into the body and minimise the side effects related to doses. The results showed that CMC/metformin@Zn-MOF encapsulation had a controlled blood sugar lowering effect and stable healing effectiveness even at a low concentration of 1:10 of local metformin. In vitro, the released concentrations from local metformin tablets and CMC/Metformin@Zn-MOF were 199.50 ppm of 500 ppm and 42.182 ppm of 50 ppm, with release percentages of 39.90% and 84.364%, respectively. This study found that metformin masking using CMC and Zn-MOF maximally produced a modified release formula along the intestine by reducing the concentration to increase tolerability in lowering blood sugar effectively for T2DM patients with minimal side effects.
Synthesis of Carboxymethyl Cellulose from Mangrove Nipah (Nypa fruticans) as Vitamin C Coating for Drug Delivery System Delviani, Delviani; Maharani, Vioala Giary Rizkillah; Shadrina, Putri Nur; Ali, Noha; Tarigan, Indra Lasmana
Chempublish Journal Vol. 8 No. 1 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i1.31722

Abstract

Vitamin C is one of the substances needed by the human body which acts as an antioxidant that effectively overcomes the effects of free radicals that damage cells in the body, but vitamin C has properties that are easily oxidized so that innovation is needed to coat (encapsulate) vitamin C in the form of capsules as a drug delivery system. One polymer that can be used for vitamin C encapsulation is cellulose. The cellulose content can be found in the skin and nipah fruit and then synthesized into carboxymethyl cellulose as a vitamin C coating. The microencapsulation method was carried out by mixing 3 g of carrageenan-CMC mixture with variations in the ratio of 1:0; 1:0.5 and 1:1 (%b/b). The encapsulated small beads were made in 200 mL of 2M KCl-CaCl solution by extrusion technique. The microencapsulant was then drained and continued with the crosslinking stage using Glutaraldehyde (GA) 1%. In this in vitro oral simulation study, the encapsulation ratio that produced the best treatment with the highest percentage of drug solubility in the intestine was the ratio (1:0.5), followed by (1:1) and the smallest (1:0) with percentage values of 15.42; 14.06; and 1.67 percent, respectively.
Co-Authors Ali, Noha Azizah, Regina Wan Delviani, Delviani Indra Lasmana Tarigan Madyawati Latief Maharani, Vioala Giary Rizkillah Maharani, Viola Giary Rizkillah Warni, Tri