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Safety of Rivaroxaban For Prophylaxis Vein Thrombosis Post Total Hip and Knee Replacement Luthfiyanti, Niken; Jayak Pratama, Kharisma; Noviana, Noviana
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4193

Orthopaedic surgery such as surgery on the pelvis and knee bones has a high risk of developing Deep Vein Thromoembolism (DVT), especially in patients with hypercoagulability. Venous thromboembolism is the main cause of morbidity and mortality in orthopedic patients that can be prevented using thromboprophylaxis, but on the other hand is related to the risk of bleeding side effects. The study aimed to evaluate the safety of oral Rivaroxaban prophylaxis in patients after Total Hip and Knee Replacement. This research applied cross sectional technique. Retrospective data were taken from the medical records of Dr. Moewardi Surakarta, period January 2023- July 2024. The data taken are secondary data from the patient's medical record by recording clinical symptoms that appear. Rivaroxaban safety evaluation includes the incidence rate of bleeding as well as the factors that influence the occurrence of bleeding. A total of 38 patients met the inclusion criteria of the study. Bleeding occurred in 4 cases (10.5%). Factors that affect the incidence of bleeding renal failure (p = 0.001). Monitoring of Rivaroxaban side effects is indispensable. Pharmaceuticals can play an important role in monitoring and preventing the occurrence of bleeding by paying attention to risk factors, especially kidney failure.

Korelasi kepatuhan minum obat dan perubahan perilaku terhadap kualitas hidup pasien hipertensi di Puskesmas Musuk Boyolali Riyanto, Riyanto; Jayak Pratama, Kharisma; Siska Wardani, Tatiana
Avicenna : Journal of Health Research Vol 8, No 2 (2025): OKTOBER
Publisher : STIKES Mamba'ul 'Ulum Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36419/avicenna.v8i2.1605

Latar belakang : Beberapa pasien hipertensi mengeluh kualitas hidupnya semakin menurun karena penyakit yang semakin memburuk, yang ditandai dengan naiknya angka tekanan darah pada orang yang sakit tersebut. Tujuan : Penelitian ini bertujuan untuk mengetahui hubungan kepatuhan minum obat dan perubahan perilaku terhadap kualitas hidup pasien hipertensi di Puskesmas Musuk Boyolali. Metode : Penelitian ini memakai cara kuantitatif dengan metode potong lintang dengan jumlah sampel 60 responden, menggunakan teknik sampling accidental sampling. Alat ukur yang digunakan adalah kuesioner MMAS, WHOQOL-BREF, dan HPLP II. Analisis untuk menilai hubungan antara kepatuhan dan kualitas hidup serta hubungan perubahan sikap dengan kualitas hidup memakai cara korelasi Spearman yang digabung dengan Chi Square. Hasil : Penelitian ini memperlihatkan bahwa di Puskesmas Musuk Boyolali, pasien tekanan darah tinggi sangat patuh minum obat sebanyak 63,3%; cukup patuh 23,3%, dan kurang patuh 13,3%. Pasien tekanan darah tinggi di Puskesmas Musuk Boyolali juga memperlihatkan perubahan sikap yang sangat baik sebanyak 48,3%; sikap cukup baik 36,7%, dan sikap kurang baik 15%. Selain itu, pasien tekanan darah tinggi di Puskesmas Musuk Boyolali merasa kualitas hidupnya baik dengan angka 48,3%; sangat baik 28,3%; kualitas hidup cukup baik 16,7%, dan kualitas hidup sangat buruk 6,7%. Kesimpulan: Penelitian ini menunjukkan bahwa terdapat hubungan bermakna antara kepatuhan minum obat dan perubahan perilaku terhadap kualitas hidup pasien hipertensi di Puskesmas Musuk Boyolali.

Pengaruh Pemberian Ekstrak Daun Alpukat (Persea Americana Mill.) terhadap Daya Ingat Mencit Jantan dengan Metode Labirin Y-Maze Meyliawati, Ika; Ardiyantoro, Bagas; Jayak Pratama, Kharisma
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6694

Memory is a vital biological system in the body that plays a role in storing, processing, and recalling information. Over time, due to aging or external factors, memory function may decline. One possible effort to maintain and improve cognitive performance is through the use of bioactive compounds with antioxidant properties. Avocado (Persea americana Mill.) leaves contain flavonoids, which act as antioxidants and possess neuroprotective effects that may enhance cognitive function, including memory. This study aimed to determine the effect of avocado leaf extract on the memory of male mice and to identify the most effective dose in improving cognitive performance. The extract was obtained using the maceration method with 70% ethanol as the solvent. Memory activity was tested on male mice, which were divided into five groups: negative control, positive control, and three treatment groups given avocado leaf extract at doses of 50, 100, and 200 mg/kgBW. The Y-Maze method was employed to assess memory through two parameters: latency time and error numbers. The results demonstrated that avocado leaf extract significantly improved memory in the test animals. Mice induced with 10% ethanol showed an increase in latency time and error numbers, while the groups treated with avocado leaf extract experienced reductions in both parameters. The most effective dose was 200 mg/kgBW, which produced a latency time difference of 19.5 seconds and an error number difference of 3.57. Therefore, avocado leaf extract shows potential as a natural agent to support and enhance cognitive function.

FORMULATION AND ACTIVITY TESTS OF ANTI-ACNE TONER ESSENTIAL OIL OF RED BETEL LEAF (Piper crocatum) Riska Permata, Bangkit; Jayak Pratama, Kharisma; Nurul Kotimah, Mei Ika
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2023: Proceeding of the 4th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v4i1.3409

Red betel leaf (Piper crocatum) is a plant that can be used as an antibacterial. Red betel leaves contain flavonoids, alkaloids, tannins, and essential oils which are thought to be used as antimicrobials. The purpose of this study was to determine the antibacterial activity of red betel leaf (Piper crocatum) essential oil facial toner as an anti-acne toner against Propionibacterium acnes bacteria. Red betel leaf is distilled to obtain essential oil, then tested for organoleptic, specific gravity, pH, viscosity, solubility in alcohol. Making facial toner preparations using concentrations of 10%, 20% and 30%. The results of the formula were then subjected to physical quality tests including organoleptic tests, pH tests, viscosity, anti-irritation tests, hedonic tests and activity tests against Propionibacterium acnes bacteria. Toner preparation activity test results obtained concentrations of 10% 9.2 mm, 20% 11.26 mm, 30% 13.46 mm. Red betel leaf essential oil toner can inhibit the growth of Propionibacterium acnes bacteria with the highest concentration of 30% obtained inhibition of 13.46 mm in the strong category.

Safety of Rivaroxaban For Prophylaxis Vein Thrombosis Post Total Hip and Knee Replacement Luthfiyanti, Niken; Jayak Pratama, Kharisma; Noviana, Noviana
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4193

Orthopaedic surgery such as surgery on the pelvis and knee bones has a high risk of developing Deep Vein Thromoembolism (DVT), especially in patients with hypercoagulability. Venous thromboembolism is the main cause of morbidity and mortality in orthopedic patients that can be prevented using thromboprophylaxis, but on the other hand is related to the risk of bleeding side effects. The study aimed to evaluate the safety of oral Rivaroxaban prophylaxis in patients after Total Hip and Knee Replacement. This research applied cross sectional technique. Retrospective data were taken from the medical records of Dr. Moewardi Surakarta, period January 2023- July 2024. The data taken are secondary data from the patient's medical record by recording clinical symptoms that appear. Rivaroxaban safety evaluation includes the incidence rate of bleeding as well as the factors that influence the occurrence of bleeding. A total of 38 patients met the inclusion criteria of the study. Bleeding occurred in 4 cases (10.5%). Factors that affect the incidence of bleeding renal failure (p = 0.001). Monitoring of Rivaroxaban side effects is indispensable. Pharmaceuticals can play an important role in monitoring and preventing the occurrence of bleeding by paying attention to risk factors, especially kidney failure.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL, FRAKSI N-HEKSAN, FRAKSI ETIL ASETAT, FRAKSI AIR DAUN RAMBUTAN (Nephelium lappaceum L.) TERHADAP BAKTERI Propionibacterium acnes ATCC 6919 Rizki Utami, Tiara; Jayak Pratama, Kharisma; Rahmatillah, Annie
Duta Pharma Journal Vol. 5 No. 2 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/f5yn2258

Latar belakang: Infeksi kulit umumnya disebabkan bakteri Propionibacterium acnes. Meningkatnya kasus resistensi antibiotik, menjadikan para peneliti mulai menggunakan tanaman sebagai alternatif pengobatan. Daun rambutan mengandung senyawa aktif tanin, alkaloid, saponin dan flavonoid yang berperan sebagai antibakteri. Tujuan: penelitian ini untuk mengetahui kemampuan daya hambat antibakteri ekstrak etanol dan fraksi dari daun rambutan. Penelitian ini merupakan penelitian eksperimen laboratorium. Metode: ekstraksi yang digunakan yaitu maserasi dengan pelarut etanol 70%. Ekstrak yang diperoleh difraksinasi menggunakan pelarut n-heksan, etil asetat, dan air. Ekstrak dan fraksi dilarutkan dengan DMSO 5% dengan konsentrasi 30%, 40%, 50% dan diuji aktivitas antibakterinya dengan metode disc diffusion untuk melihat zona hambatnya. Kontrol positif menggunakan disk clindamycin, sedangkan kontrol negatif menggunakan DMSO 5%. Hasil: penelitian menunjukkan zona hambat daun rambutan terhadap pertumbuhan Propionibacterium acnes ATCC 6919 diurutkan dari yang paling besar fraksi etil asetat konsentrasi tertinggi 50% rata-rata 8,36 mm, ekstrak etanol konsentrasi tertinggi 50% yaitu 5,3 mm, fraksi n-heksan konsentrasi tertinggi 50% rata-rata 3,00 mm, dan fraksi air konsentrasi tinggi 50% rata-rata 1,06 mm. Data dianalisis menggunakan SPSS 23 dengan metode ANOVA. Kesimpulan: signifikansi ANOVA menunjukkan nilai 0,00 yang berarti p < 0,05. Hal ini mengindikasikan terdapat perbedaan yang signifikan dalam diameter zona hambat antar kelompok sampel yang diuji.

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