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All Journal Jurnal Biologi Tropis Jurnal Kesehatan Tambusai
Larasati, Alifia Amanda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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TINJAUAN PUSTAKA : ADENOMA TIROID, DEFINISI HINGGA PROGNOSIS Ragad, Putra; Aritiah, Muhammad Awallul Rizky; Rizaldi, Muhammad Hilman; Haq, Andi Muhammad Al Fatih; Arsy, Lazuardy; Larasati, Alifia Amanda; Karlina, Fairuz; Aishwarya, Ni Wayan Devian; Kamila, Alya Syafa; Putri, Ni Putu Ayu Nindya Dewi Cahya
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.39270

Abstract

Kelenjar tiroid merupakan kelenjar endokrin terbesar di dalam tubuh manusia yang dapat mengalami kelainan seperti lesi. Lesi diperkirakan 4-7% yang menderita. Lesi pada tiroid kebanyakan bersifat non kanker salah satunya adalah adenoma tiroid. Adenoma tiroid dapat disebabkan oleh banyak faktor seperti faktor lingkungan, mutasi genetik, defisiensi yodium, pemakaian radiologi yang berlebihan, pemeriksaan pada adenoma dapat dilakukan dengan pemeriksaan fisik dan pemeriksaan laboratorium. Metode penelitian ini menggunakan metode pendekatan naratif yang membahas mengenai artikel yang didapat atau review artikel dengan menggumpulkan data dari basis data online seperti Google Scholar, PubMed, ScienceDirect, Frontiers dan MDPI yang sumber literatur didapatkan dari rentang waktu 2011-2024. Kajian ini dilakukan secara menyeluruh mulai dari definisi, etiologi, faktor risiko, epidemiologi, patofisiologi, manifestasi klinis, diagnosis, tatalaksana, komplikasi dan prognosis dari penyakit adenoma tiroid. Berdasarkan hasil literatur yang didapatkan adenoma tiroid merupakan penyakit yang keberadaan tidak kita sadari dan biasanya terdiagnosis ketika melakukan pemeriksaan lain. Meskipun prognosis pada adenoma tiroid cenderung baik namun Anamnesis, pemeriksaan fisik dan pemeriksaan laboratorium secara menyeluruh penting dalam mendiagnosis adenoma tiroid agar tidak terjadi komplikasi yang mengarah kepada keganasan. Kesimpulan dari tinjauan pustaka ini adalah pengetahuan terkait adenoma tiroid seperti etiologi, faktor risiko, diagnosis dan penatalaksanaannya sangat penting dalam mendeteksi sekaligus dapat mengobati adenoma tiroid serta dapat mencegah komplikasi yang muncul.
Antibacterial Activity of Centella asiatica N-Hexane Fraction against Pseudomonas aeruginosa Clinical Isolates Larasati, Alifia Amanda; Rosyunita; Fathul Djannah
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7724

Abstract

Pseudomonas aeruginosa is a gram-negative bacterium that causes infections with high morbidity and mortality rates. Currently, treatment of P. aeruginosa infections is a major challenge due to its ability to resist various available antibiotics. Among the herbal plants with potential as a novel antibacterial agent is Centella asiatica. Nevertheless, the n-hexane fraction has never been used to investigate the antibacterial activity of C. asiatica as a herbal plant. This study aims to determine the antibacterial activity of the n-hexane fraction of C. asiatica by sokhletation extraction method against clinical isolates of P. aeruginosa and determine the bioactive compounds contained. The method used was disc diffusion (Kirby-Bauer test) with concentrations of 5,000 ppm, 7,500 ppm, and 10,000 ppm, positive control using 10 μg colistin and negative control using 10% DMSO. The results showed that the three test concentrations of C. asiatica n-hexane fraction formed a clear zone of 2.50 mm; 4.77 mm, and 2.43 mm respectively and contained flavonoid and steroid compounds. Statistically, Kruskal-Wallis test showed that there was a significant effect of changing the concentration of n-hexane fraction on the diameter of the inhibition zone. However, Post hoc test using Mann-Whitney showed that the three concentration series had significant differences in inhibition against the positive control. Overall, the n-hexane fraction of C. asiatica had lower antibacterial activity compared to the positive control of colistin. In future studies, it is necessary to test antibacterial activity using a more varied concentration series and other antibacterial activity test methods.
Co-Authors Aishwarya, Ni Wayan Devian Aritiah, Muhammad Awallul Rizky Arsy, Lazuardy Fathul Djannah Haq, Andi Muhammad Al Fatih Kamila, Alya Syafa Karlina, Fairuz Putri, Ni Putu Ayu Nindya Dewi Cahya Ragad, Putra Rizaldi, Muhammad Hilman Rosyunita