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All Journal Hearty : Jurnal Kesehatan Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Kesehatan Tambusai Biocaster : Jurnal Kajian Biologi Promotor: Jurnal Mahasiswa Kesehatan Masyarakat El-Mujtama: Jurnal Pengabdian Masyarakat
Christanto, Antonius
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Systematic Journal Review: Mechanical Durability Of L-PRF Organic Material At Body Temperature During The Wound Healing Phase (14 Days) Of Tympanic Membrane Perforation And Myringoplasty Surgery Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
PROMOTOR Vol. 9 No. 1 (2026): FEBRUARI
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v9i1.1741

Abstract

The purpose of this study is to evaluate the viability and structural stability of L-PRF at 37°C over 14 days. It aims to determine its sustained growth factor release and potential effectiveness in regenerative clinical applications. This research employed a Systematic Journal Review (SJR) approach, surveying articles from databases such as PubMed, Scopus, and Google Scholar using specific keywords related to L-PRF. A total of 25 articles meeting the inclusion criteria were filtered for analysis. Furthermore, common experimental methods described in the literature include the preparation of L-PRF via blood centrifugation and viability testing over 14 days at 37°C, encompassing analysis of microscopic structure, mechanical properties, and biochemical and biological activities. Literature analysis indicates that L-PRF is an effective autologous biomaterial for regenerative applications, capable of continuously releasing growth factors such as PDGF, TGF-β, VEGF, and IGF for up to 14 days at body temperature. Cell viability within the fibrin matrix is maintained, positioning L-PRF as a promising active biological scaffold for accelerating tissue healing. Although challenges such as matrix degradation persist, modification strategies and optimized centrifugation protocols can enhance the effectiveness and durability of L-PRF in clinical applications.
Keunggulan Leukocyte Platelet-Rich Fibrin (L-PRF) Dibanding Jenis PRF Lain (P-PRF, PRFM, I-PRF, A-PRF) Pada Patch Dan Graft Miringoplasti: Sebuah Tinjauan Sistematis Mahfuzhi, Aris; Christanto, Antonius
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 2 (2026): Volume 13 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i2.22706

Abstract

Perforasi membran timpani (MT) merupakan masalah klinis yang menimbulkan gangguan pendengaran, infeksi berulang, dan penurunan kualitas hidup. Penutupan perforasi dilakukan melalui patch miringoplasti untuk ukuran kecil–sedang atau graft miringoplasti untuk perforasi lebih besar. Perkembangan bioteknologi memperkenalkan platelet concentrate sebagai biomaterial regeneratif, termasuk Platelet-Rich Fibrin (PRF). Di antara variannya, Leukocyte Platelet-Rich Fibrin (L-PRF) memiliki keunggulan biologis dan klinis. Artikel ini meninjau keunggulan L-PRF dibandingkan P-PRF, PRFM, I-PRF, dan A-PRF dalam patch maupun graft miringoplasti. Kajian disusun sebagai systematic review dengan pencarian sistematis pada PubMed, ScienceDirect, Scopus, dan Google Scholar (2010–2025). L-PRF mengandung leukosit tinggi, melepaskan faktor pertumbuhan hingga 14 hari, dan memiliki matriks fibrin padat sebagai scaffold alami. Pada patch, L-PRF efektif sebagai bahan utama untuk perforasi kecil–sedang, sedangkan pada graft berperan sebagai adjuvan yang memperkuat integrasi cangkok. L-PRF lebih konsisten mendukung regenerasi jaringan dibanding varian lain, meskipun penelitian lebih lanjut masih dibutuhkan.
Co-Authors Eti Poncorini Pamungkasari Ida Nurwati Mahfuzhi, Aris Paramasari Dirgahayu Risya Cilmiaty, Risya Setiamika, Made Yudhani, Ratih Dewi