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All Journal Hearty : Jurnal Kesehatan Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Tambusai Biocaster : Jurnal Kajian Biologi Promotor: Jurnal Mahasiswa Kesehatan Masyarakat El-Mujtama: Jurnal Pengabdian Masyarakat
Christanto, Antonius
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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SYSTEMATIC LITERATURE REVIEW TENTANG FRAKTUR OS NASAL: TREN PENELITIAN, DIAGNOSIS, DAN PENATALAKSANAAN Christanto, Antonius
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.45524

Abstract

Fraktur os nasal merupakan cedera wajah yang paling umum, namun pendekatan diagnosis dan penatalaksanaannya terus berkembang seiring kemajuan teknologi medis. Penelitian ini bertujuan untuk mengeksplorasi tren terkini dalam diagnosis, penatalaksanaan, dan metode pengobatan fraktur os nasal melalui pendekatan Systematic Literature Review (SLR). Proses pencarian artikel dilakukan pada basis data PubMed, ScienceDirect, dan Google Scholar. Setelah melalui tahap seleksi berdasarkan kriteria inklusi, diperoleh 22 artikel yang relevan untuk dianalisis. Hasil studi menunjukkan bahwa teknologi pencitraan, khususnya CT-scan, semakin sering digunakan dalam diagnosis fraktur kompleks karena mampu memberikan visualisasi anatomi yang lebih detail, sementara radiografi konvensional masih digunakan untuk kasus ringan. Dalam hal penatalaksanaan, terdapat dua pendekatan utama yaitu konservatif dan operatif. Pendekatan konservatif diterapkan pada fraktur tanpa dislokasi, sedangkan penanganan operatif seperti reposisi tertutup atau rinoplasti diperlukan untuk fraktur kompleks. Faktor yang memengaruhi pemilihan terapi mencakup tingkat keparahan cedera, pertimbangan estetika, preferensi pasien, hingga aspek psikologis dan kualitas hidup. Simpulan dari studi ini menegaskan pentingnya pendekatan yang individual dan holistik dalam penanganan fraktur os nasal. Penelitian juga merekomendasikan pelatihan berkelanjutan bagi praktisi medis serta studi lebih lanjut mengenai inovasi terapi dan evaluasi jangka panjang terhadap berbagai metode penanganan.
PROSES WOUND HEALING PADA PERFORASI MEMBRAN TIMPANI: TINJAUAN SISTEMATIS LITERATUR Christanto, Antonius
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.45525

Abstract

Perforasi membran timpani merupakan kondisi klinis yang dapat mengganggu fungsi pendengaran dan kualitas hidup pasien. Penanganan konvensional seperti miringoplasti sering menghadapi keterbatasan dalam regenerasi struktural dan fungsional. Oleh karena itu, tinjauan sistematis ini bertujuan untuk mengidentifikasi dan mengevaluasi pendekatan terapeutik terkini yang mendukung proses penyembuhan luka pada perforasi membran timpani, dengan fokus pada pemanfaatan biomaterial dan teknologi rekayasa jaringan. Pencarian literatur dilakukan melalui lima basis data utama: PubMed, ScienceDirect, DOAJ, Google Scholar, dan MDPI, mencakup publikasi antara tahun 2019 hingga 2024. Studi yang disertakan terdiri dari penelitian eksperimental, klinis, serta tinjauan sistematis yang membahas strategi intervensi biologis terhadap penyembuhan membran timpani. Penilaian kualitas metodologis menggunakan pedoman dari Joanna Briggs Institute. Hasil menunjukkan bahwa biomaterial seperti platelet-rich fibrin (PRF), kolagen, dan scaffold polimer bioaktif dapat mempercepat regenerasi jaringan timpani. Teknologi 3D printing memungkinkan penciptaan scaffold yang menyerupai struktur asli membran, mendukung pemulihan fungsional. Penggunaan sel punca mesenkimal dan sensor bioelektronik juga menonjol sebagai pendekatan inovatif dalam terapi personalisasi. Simpulannya, kombinasi biomaterial dan teknologi rekayasa jaringan terbukti efektif mempercepat epitelisasi, merangsang angiogenesis, serta meningkatkan integritas struktural hasil regenerasi. Pendekatan ini membuka peluang untuk pengembangan terapi regeneratif yang lebih presisi, minim invasif, dan berorientasi pada pemulihan optimal fungsi pendengaran.
Analisis Meta Teknik Grafting dalam Rhinoplasty: Evaluasi terhadap Hasil Estetika dan Komplikasi Christanto, Antonius
El-Mujtama: Jurnal Pengabdian Masyarakat  Vol. 5 No. 3 (2025): El-Mujtama: Jurnal Pengabdian Masyarakat
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/elmujtama.v5i3.8145

Abstract

This study aims to analyze the effectiveness of various grafting techniques in rhinoplasty procedures, particularly in relation to aesthetic outcomes and postoperative complications. Utilizing a systematic meta-analytical approach in this research reviewed 22 relevant scientific publications from leading databases, including PubMed and ScienceDirect. The analysis focused on the use of autologous, alloplastic, and acellular dermal grafts, as well as combined techniques such as diced cartilage wrapped in fascia (DC-F). Findings indicate that autologous grafts—particularly septal and auricular cartilage—offer superior structural stability and the highest patient satisfaction, with a low complication rate (<5%). Acellular dermal grafts and DC-F techniques were effective in revision cases, while alloplastic grafts showed a higher complication rate, including extrusion and infection. Spreader graft techniques also demonstrated improvement in postoperative nasal function. The discussion highlights the critical importance of selecting grafting techniques based on the patient’s anatomical condition and individualized needs. Autologous grafts remain the gold standard in primary rhinoplasty, while combination techniques provide effective solutions for complex cases. In conclusion, the success of rhinoplasty strongly depends on choosing the appropriate grafting method, with thorough consideration of aesthetic goals, functional outcomes, and complication risks.
Kajian Bibliometrik terhadap Publikasi Ilmiah tentang Septoplasty: Visualisasi Tren dan Topik Populer Christanto, Antonius
El-Mujtama: Jurnal Pengabdian Masyarakat  Vol. 5 No. 3 (2025): El-Mujtama: Jurnal Pengabdian Masyarakat
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/elmujtama.v5i3.8146

Abstract

This study aims to analyze trends and popular topics in scientific publications on septoplasty using bibliometric methods. Bibliometric analysis is used to measure and map scientific publication data, including the number of publications, authors, institutions, and frequently occurring keywords. The data were collected from international scientific databases and then analyzed using visualization techniques such as keyword mapping, author collaboration networks, and citation analysis. The results show that the number of publications on septoplasty has increased significantly in recent years, with main focuses on surgical techniques, clinical outcomes, and complications. Furthermore, this study identifies the most productive authors and institutions as well as patterns of international collaboration. These findings provide a comprehensive overview of the development of septoplasty research and serve as an important reference for future studies.
The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

Abstract

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.
SYSTEMATIC JOURNAL REVIEW (SJR): CURRENT MANAGEMENT OF PREURICULAR FISTULA WITH AND WITHOUT ABSCESS Christanto, Antonius
HEARTY Vol 13 No 5 (2025): OKTOBER
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i5.20440

Abstract

Preauricular fistula is a congenital anomaly that may lead to recurrent infections and abscess formation. Its management typically involves a combination of antibiotic therapy and surgical interventions, such as tract excision or a supra-auricular approach, which have been shown to reduce recurrence rates. However, a standardized clinical consensus regarding the optimal treatment method remains lacking. This systematic review aims to identify the most effective diagnostic and therapeutic strategies based on the latest scientific evidence to assist clinicians in managing these cases optimally. This study employed the Systematic Journal Review (SJR) method to critically appraise the scientific literature concerning the management of preauricular fistulas, both with and without abscess formation. A structured approach following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was used, with data sourced from reputable databases including PubMed, Scopus, ScienceDirect, and Google Scholar. Articles were selected based on stringent inclusion and exclusion criteria through a stepwise process, from keyword search to full-text appraisal, yielding 27 eligible studies for comprehensive analysis. Findings from this review emphasize the importance of complete fistula tract excision to prevent recurrence, highlighting various surgical techniques such as hidden incisions and local skin flaps that enhance both aesthetic and clinical outcomes. Standardized procedures, including the use of magnification and methylene blue dye, are also considered essential to ensure complete excision. Nevertheless, limitations such as study heterogeneity, small sample sizes, and lack of controlled trials restrict the strength of conclusions and meta-analytic synthesis. Therefore, further research with robust design, larger sample sizes, standardized protocols, and the inclusion of negative findings is necessary to strengthen the evidence base for preauricular fistula management.
Systematic Journal Review: Mechanical Durability Of L-PRF Organic Material At Body Temperature During The Wound Healing Phase (14 Days) Of Tympanic Membrane Perforation And Myringoplasty Surgery Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
PROMOTOR Vol. 9 No. 1 (2026): FEBRUARI
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v9i1.1741

Abstract

The purpose of this study is to evaluate the viability and structural stability of L-PRF at 37°C over 14 days. It aims to determine its sustained growth factor release and potential effectiveness in regenerative clinical applications. This research employed a Systematic Journal Review (SJR) approach, surveying articles from databases such as PubMed, Scopus, and Google Scholar using specific keywords related to L-PRF. A total of 25 articles meeting the inclusion criteria were filtered for analysis. Furthermore, common experimental methods described in the literature include the preparation of L-PRF via blood centrifugation and viability testing over 14 days at 37°C, encompassing analysis of microscopic structure, mechanical properties, and biochemical and biological activities. Literature analysis indicates that L-PRF is an effective autologous biomaterial for regenerative applications, capable of continuously releasing growth factors such as PDGF, TGF-β, VEGF, and IGF for up to 14 days at body temperature. Cell viability within the fibrin matrix is maintained, positioning L-PRF as a promising active biological scaffold for accelerating tissue healing. Although challenges such as matrix degradation persist, modification strategies and optimized centrifugation protocols can enhance the effectiveness and durability of L-PRF in clinical applications.
Keunggulan Leukocyte Platelet-Rich Fibrin (L-PRF) Dibanding Jenis PRF Lain (P-PRF, PRFM, I-PRF, A-PRF) Pada Patch Dan Graft Miringoplasti: Sebuah Tinjauan Sistematis Mahfuzhi, Aris; Christanto, Antonius
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 2 (2026): Volume 13 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i2.22706

Abstract

Perforasi membran timpani (MT) merupakan masalah klinis yang menimbulkan gangguan pendengaran, infeksi berulang, dan penurunan kualitas hidup. Penutupan perforasi dilakukan melalui patch miringoplasti untuk ukuran kecil–sedang atau graft miringoplasti untuk perforasi lebih besar. Perkembangan bioteknologi memperkenalkan platelet concentrate sebagai biomaterial regeneratif, termasuk Platelet-Rich Fibrin (PRF). Di antara variannya, Leukocyte Platelet-Rich Fibrin (L-PRF) memiliki keunggulan biologis dan klinis. Artikel ini meninjau keunggulan L-PRF dibandingkan P-PRF, PRFM, I-PRF, dan A-PRF dalam patch maupun graft miringoplasti. Kajian disusun sebagai systematic review dengan pencarian sistematis pada PubMed, ScienceDirect, Scopus, dan Google Scholar (2010–2025). L-PRF mengandung leukosit tinggi, melepaskan faktor pertumbuhan hingga 14 hari, dan memiliki matriks fibrin padat sebagai scaffold alami. Pada patch, L-PRF efektif sebagai bahan utama untuk perforasi kecil–sedang, sedangkan pada graft berperan sebagai adjuvan yang memperkuat integrasi cangkok. L-PRF lebih konsisten mendukung regenerasi jaringan dibanding varian lain, meskipun penelitian lebih lanjut masih dibutuhkan.
Co-Authors Eti Poncorini Pamungkasari Ida Nurwati Mahfuzhi, Aris Paramasari Dirgahayu Ratih Dewi Yudhani Risya Cilmiaty, Risya Setiamika, Made