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All Journal Jurnal Sains & Teknologi Lingkungan Science Midwifery
Silalahi, Ali Affan
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Computer Science & IT Dentistry Education Health Professions Nursing Public Health Veterinary

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Molecular Docking in red spinach plants (Amaranthus tricolor L.) as an inhibitory agent for genetic anemia Fattara, Fajar Putra; Idami, Zahratul; Silalahi, Ali Affan
Science Midwifery Vol 12 No 3 (2024): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i3.1660

Abstract

This study aims to evaluate the potential of active compounds from the Red Spinach plant (Amaranthus tricolor L.) as an inhibitor agent for the genetic disease anemia through a molecular docking approach. The method used involved analyzing the 3D structures of four active compounds Phenol, Lutein, Quercetin, and Zeaxanthin in these plants, which were downloaded from PubChem and processed using the Swiss software Target Prediction, Super Prediction, PyMol, and PyRx. The interaction between the compound and the biological target, in this case, Erythropoietin, is evaluated to determine binding energy, binding affinity, and stability. The results showed that Phenol and Quercetin had a significant interaction with the lowest binding energy of -4.8 kcal/mol and -8.1 kcal/mol respectively, as well as the lowest RMSD value (0 Å), indicating good interaction stability with the protein target. The 3D molecular structure of these two compounds also indicates the presence of hydrogen bonds and effective interactions with amino acids, as well as low toxicity and favorable affinity energies. Based on these results, Phenol and Quercetin were identified as potential candidates in the development of drugs to treat anemia genetic diseases, thanks to their favorable interaction properties and molecular structural characteristics. This research underlines the importance of the molecular docking approach in identifying bioactive compounds that can be further developed as therapies for the genetic disease anemia.
Karbon Aktif Kulit Bawang Merah (Allium ascalonicum) untuk Mereduksi Bilangan Asam dan Peroksida: Indonesia Lubis, Ridwan Yusuf; Insani, Rizki; Husnah, Miftahul; Silalahi, Ali Affan
Jurnal Sains & Teknologi Lingkungan Vol. 18 No. 1 (2026): SAINS & TEKNOLOGI LINGKUNGAN
Publisher : Teknik Lingkungan Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jstl.vol18.iss1.art3

Abstract

Activated carbon is one of the adsorption materials commonly used to improve the quality of used cooking oil. This study aims to determine the effect of varying concentrations of phosphoric acid (H₃PO₄) as a chemical activator on activated carbon derived from red onion peel. The research data were expressed quantitatively through physical and chemical characterization, while the results of color and odor tests were presented descriptively. Activated carbon from red onion peel was successfully produced through physical activation (400 °C) and chemical activation (H₃PO₄) with concentration variations A (8%), B (12%), C (16%), and D (20%). The characterization results showed a decrease in moisture content, ash content, and volatile matter content, while the carbon content increased. Sample D met the requirements of SNI 06-3730-1995 for all physical and chemical characteristics. An increase in adsorption ability for acid value was observed in line with the increase in activator concentration. The ability to reduce peroxide value decreased in samples C and D compared to sample B, but still met the SNI 3741:2013 standard. The most optimal characterization and adsorption performance were obtained in sample D, with an acid value of 0.33% (mg KOH/kg) and a peroxide value of 8 (meq O₂/kg).
Co-Authors Elanda, Yurike Fattara, Fajar Putra Harahap, Armansyah Maulana Insani, Rizki Lubis, Ridwan Yusuf Miftahul Husnah Rambe, Robiatun Yetty Machrina Zahratul Idami