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All Journal Sumatera Medical Journal Best Journal (Biology Education, Sains and Technology) Journal of Innovative and Creativity
Elanda, Yurike
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Examined study of the impact of ethanol extract from Sirih China (Peperomia pellucida L.) ointment on the histological appearance of the epidermis and the duration of burn healing in mice (Mus musculus) Harahap, Armansyah Maulana; Salamah, Salamah; Rambe, Robiatun; Elanda, Yurike; Khairunnisa, Nur Aini; Priawan, Indra
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10460

Abstract

Burns are a condition where there is damage to the epidermis layer down to the dermis layer. The skin structure sustains damage from the epithelium to the basal layer of the dermis. You can use the herbal Chinese pepper (Peperomia pellucida L.) for burn treatment. This study aims to evaluate the impact of administering Chinese betel leaf ointment, with variations in concentration and formula, on the duration of burn wound healing and the diameter of wound closure. Methods There were 30 Mus musculus mice in this study. Divided them into five groups: a regular group without burns, a positive control group that received gentamicin, treatment group 1 that received a low concentration 5% ethanol extract of Chinese betel leaf (EECB) ointment, a treatment group 2 that received a low concentration 10% EECB ointment, and a treatment group 3 that received a high concentration 15% EECB ointment. Results demonstrate wound closure activity by measuring the diameter of burn wounds treated with a 15% concentration of Chinese pepper ointment on the 18th day and a 15% concentration closed the burn wound. Histopathological differences were seen in the K3 group, where collagen density scored +3 (±0.06). We found a very weak positive correlation (0.000) between histopathology (collagen) and wound diameter and a strong negative correlation (-0.0527) between the histopathological parameter (collagen) and the duration of burn wound healing. Conclusion. The research concludes that the effectiveness of administering Chinese betel leaf ointment with a concentration of 15% was obtained
Potensi Antibakteri Fraksi n-Heksan Daun Sembung (Blumea balsamifera L.) Terhadap Bakteri Eschericia coli, Staphylococcus aureus dan Propionibacterium acnes dengan Metode Welling Diffusion Rizky, Erika; Husein, Saddam; Khairunnisa, Nur Aini; Elanda, Yurike
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.11049

Abstract

Tanaman daun sembung (Blumea balsamifera L.) adalah obat tradisional yang digunakan untuk mengobati batu ginjal, diare, masalah perut, dan sebagai rempah-rempah sauna tradisional. Dikenal juga sifat antibakterinya yang alami dan dapat menahan perkembangan kanker dan tumor. Tujuan penelitian ini adalah untuk menilai karakteristik simplisia, golongan kimia tumbuhan, fraksi n-heksana daun sembung dan aktivitasnya dalam menahan perkembangan biakan bakteri S.aureus, P.acnes dan E.coli. Penelitian dilaksanakan meliputi seperti pengumpulan bahan baku daun sembung, pengujian karakteristik, maserasi serbuk simplisia daun sembung menggunakan pelarut etanol 96%, uji skrining fitokimia, fraksinasi ekstrak etanol B. balsamifera menggunakan pelarut n-heksana yang kemudian diuji aktivitas antibakterinya pada fraksi n-heksana daun sembung (FHDS) terhadap bakteri Propionibacterium acnes, Staphylococcus aureus, dan Escherichia coli dengan konsentrasi 100, 200, 300, 400 dan 500 mg/ml menggunakan metode difusi agar sumuran dengan mengamati zona hambat maksimum. Berdasarkan hasil pemeriksaan golongan senyawa pada FHDS, terdapat golongan senyawa kimia tumbuhan, yaitu alkaloid, flavonoid, tanin, saponin, dan steroid. Investigasi aktivitas antibakteri FHDS menunjukkan aktivitasnya pada FHDS (500 mg/ml, 400 mg/ml, 300 mg/ml, 200 mg/ml, dan 100 mg/ml) dalam menahan perkembang biakan bakteri E. coli, S. aureus, dan P. acnes. Aktivitas antibakteri terkuat ditunjukkan pada FHDS dengan konsentrasi 500 mg/ml (16.5 mm). Berdasarkan hasil penelitian, dapat disimpulkan bahwa FHDS mempunyai efikasi sebagai antibakteri yang dikategorikan kuat dan mampu menghambat perkembang biakan bakteri E. coli, S. aureus, dan P. acnes
Anti-Inflammatory Activity Test of Ethanolic Extract of Transdermal Patch Crinum asiaticum L Against Male Wistar Rats Induced by Carrageenan Rambe, Robiatun; Harahap, Armansyah Maulana; Elanda, Yurike; Silalahi, Ali Affan; Machrina, Yetty
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.17888

Abstract

Background:Crinum asiaticum leaves are recognized for their wound healing properties, particularly in treating abrasive or inflamed wounds. Objective: This study aims to evaluate the efficacy of a transdermal patch prepared from Crinum asiaticum leaf extracts in reducing inflammation. Methods: The preparation involved applying coconut oil to the fruit, roasting it, and then using it on the affected area. Leaf samples and extracts were utilized to formulate transdermal patches at three different concentrations (1%, 3%, and 5%). The patches were assessed organoleptically for thickness, weight uniformity, folding resistance, and pH. Results: The findings demonstrated that the 5% concentration transdermal patches exhibited superior anti-inflammatory effects compared to the 1% and 3% concentrations. This suggests that higher concentrations of Crinum asiaticum extracts enhance the therapeutic potential of transdermal applications. Conclusion: The study concludes that transdermal patches formulated with Crinum asiaticum leaves are effective in reducing inflammation, with 5% concentration offering the highest efficacy. Further research is recommended to explore the clinical applications of these patches in wound management.
Pengaruh Konseling Terhadap Pemahaman Pengobatan Pasien Tuberkulosis Di Puskesmas Pringsewu Elanda, Yurike; Pisacha, Iga Mayola; Safutri, Wina; Logawan, Nanggroe
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i3.3681

Abstract

Tuberkulosis (TB) merupakan penyakit menular yang masih menjadi masalah kesehatan global, termasuk di Indonesia. Kepatuhan dan pemahaman pasien terhadap pengobatan memegang peranan penting dalam keberhasilan terapi. Penelitian ini bertujuan untuk mengetahui pengaruh konseling terhadap pemahaman pengobatan pasien tuberkulosis di Puskesmas Pringsewu. Desain penelitian menggunakan pra-eksperimental dengan rancangan one group pre–post test design. Sampel penelitian berjumlah 51 pasien TB yang memenuhi kriteria inklusi, diambil dengan teknik total sampling. Instrumen penelitian berupa kuesioner untuk mengukur tingkat pemahaman sebelum dan sesudah pemberian konseling. Analisis data menggunakan uji Wilcoxon karena data tidak berdistribusi normal. Hasil penelitian menunjukkan rata-rata skor pemahaman sebelum konseling adalah 5,59 (SD = 1,682) dan meningkat menjadi 6,91 (SD = 0,920) setelah konseling, dengan selisih mean 1,32. Uji Wilcoxon menghasilkan nilai p = 0,000 (< 0,05), yang berarti terdapat pengaruh signifikan konseling terhadap peningkatan pemahaman pengobatan pasien TB. Kesimpulannya, pemberian konseling efektif meningkatkan pemahaman pasien mengenai pengobatan TB di Puskesmas Pringsewu. Disarankan tenaga kesehatan rutin memberikan konseling yang komprehensif guna mendukung keberhasilan terapi.
Co-Authors Harahap, Armansyah Maulana Khairunnisa, Nur Aini Logawan, Nanggroe Pisacha, Iga Mayola Priawan, Indra Rambe, Robiatun Rizky, Erika Saddam Husein, Saddam salamah salamah Silalahi, Ali Affan Wina Safutri Yetty Machrina