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All Journal ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Kartika Kimia Gunung Djati Conference Series Advanced Journal of STEM Education (AJOSED)
Erianti Siska Purnamasari
International Women University
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Selection of the Parameters in the Synthesis of Ethylenediamine-Folate Using the Plackett Burman Design Erianti Siska Purnamasari; Linda Septiana; Ari Hardianto; Ukun Mochammad Syukur Soedjanaatmadja; Anni Anggraeni; Husein Hernadi Bahti
Indonesian Journal of Chemistry Vol 22, No 3 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.68313

Abstract

This study is concerned with synthesizing ethylenediamine-folate (EDA-Folate), which will then be used as a precursor in synthesizing Gd-PEG-DOTA-Folate, a novel targeted-contrast agent for the diagnosis of cancer, employing the Magnetic Resonance Imaging method. This study aims to determine all the parameters affecting the synthesis of EDA-Folate using the Plackett Burman design. The synthesis method included activation of folic acid using dicyclohexylcarbodiimide and N-Hydroxysuccinimide to result in NHS-Folate, followed by conjugation of ethylenediamine with NHS-Folate to produce EDA-Folate. Analysis of the reaction product confirmed that the reaction product was EDA-Folate. From the resulted data, it can also be concluded that there were four significant parameters (out of the ten parameters studied) in the synthesis of EDA-Folate (with its value presented in the bracket), i.e., time inactivation of NHS-Folate (24 h), stirring rate inactivation of NHS-Folate (300 rpm), the mole of EDA (12 moles), and time of EDA-Folate (12 h). Moreover, the value or desirability of the experimental design was found to be 0.875 (which is < 1.0), meaning that the design will produce optimal conditions and thus the optimal yield of the reaction.
Sintesis Senyawa (1,4,7,10- Tetraazasiklodosekana 1,4,7,10-Tetraasetat)-Folat Sebagai Prekursor Senyawa Pengontras Terarah [Gadolinium-(1,4,7,10- Tetraazasiklodosekana 1,4,7,10-Tetraasetat)-Folat] Erianti Siska Purnamasari
Gunung Djati Conference Series Vol. 44 (2024): Seminar Nasional (SEMNAS) Kimia Tahun 2024
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Magnetic Resonance Imaging (MRI) merupakan modalitas pencitraan non-ivasif yang paling fleksibel dan kuat untuk penggunaan klinis dalam beberapa waktu terakhir. Untuk meningkatkan kualitas gambar yang dihasilkan dalam MRI, sejauh ini telah digunakan senyawa-senyawa kimia yang disebut senyawa pengontras (contrast agent). Gd-DOTA-Folat dengan linker etilendiamin merupakan salah satu senyawa pengontras terarah yang sedang dikembangkan. Sintesis Gd-DOTA-Folat melalui tiga tahap reaksi utama, yaitu 1). Reaksi pembentukan EDA-Folat (etilendiamina-folat), 2). Reaksi pembentukan DOTA-Folat, dan 3). Reaksi pembentukan Gd-DOTA-Folat. Tujuan dari penelitian ini adalah mensintesis prekursor DOTA-Folat sebagai salah satu prekursor dalam sintesis senyawa pengontras Gd-DOTA Folat melalui dua tahap reaksi, yaitu 1). Aktivasi DOTA menggunakan DCC dan NHS menghasilkan DOTA-NHS-Ester, 2). Konjugasi DOTA-NHS-Ester dengan prekursor EDA-Folat menghasilkan DOTA-Folat. Produk senyawa kompleks DOTA-Folat yang dihasilkan dimurnikan dan dikarakterisasi menggunakan metode spektrofotometri ultraviolet (UV), Fourier Transform Infrared Spectroscopy (FTIR) dan spektrometri massa (MS). Hasil karakterisasi dengan spektrometri massa diperoleh nilai m/z sebesar 870,7224, DOTA-Folat dengan penambahan sebuah proton [M-H+] (DOTA-Folat secara teoritis memiliki m/z sebesar 869,8810).
Verifikasi Metode Uji Penetapan Logam Terlarut Mangan pada Air Menggunakan Inductively Coupled Plasma Mass Spectrometer Salimi, Sonny; Wahyuni, Sri; Pratama, Intan; Purnamasari, Erianti Siska
Jurnal Kartika Kimia Vol 8 No 1 (2025): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i1.908

Abstract

Clean water is defined as water used for daily needs that meets the quality standards set by regulations. To qualify as clean water, it must undergo physical and chemical testing, including metal content analysis. One such metal is manganese, which is regulated with a maximum allowable concentration of 100 µg/L due to its potential to cause chronic toxicity at high levels. This study aimed to determine the concentration of dissolved manganese in clean water samples using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method at LPKL Perumda Tirtawening. Method verification was conducted to ensure the reliability and accuracy of the analysis. The results demonstrated excellent linearity (r ≥ 0.995), a detection limit below 100 µg/L, precision with %RSD < 0.5 CV Horwitz, and accuracy with a %recovery of 102.03%. These findings confirm that the ICP-MS method is valid and suitable for manganese testing in clean water at LPKL Perumda Tirtawening.
A Study on the Synthesis of [Gadolinium-( 1,4,7,10 -Tetraazacyclododecane 1,4,7,10 Tetraacetate Acid)-Folate] as a Targeted Contrast Agent for Cancer Diagnosis Using Magnetic Resonance Imaging Erianti Siska Purnamasari; Husein Hernadi Bahti
Advanced Journal of STEM Education Vol. 2 No. 2 (2024): Advanced Journal for STEM Education (AJOSED)
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/ajosed.v2i2.2483

Abstract

Optimization of Poly Aluminum Chloride Liquid Dosage in Clean Water Treatment Using Box-Behnken Design Purnamasari, Erianti Siska; Patrakomala, Nira; Wahyuni, Sri; Salimi, Sonny
Jurnal Kartika Kimia Vol 8 No 2 (2025): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i2.978

Abstract

Various human activities that are increasing will have an impact on the decline in the quality of raw water, a key source of clean water production. To achieve optimal results in the clean water treatment process, a suitable formulation is required for the addition of liquid PAC, which acts as a coagulant to reduce the turbidity level of raw water. Currently, the formulation of liquid PAC dosage in raw water treatment has an accuracy level of less than 70%. Therefore, a method is needed to improve the accuracy level of PAC dosage. Box-Behnken Design (BBD) is one of the RSM design methods, which can analyze problems whose responses are influenced by several variables, where the interaction can be used to predict the optimal formula. This study aims to determine the optimal dosage of liquid PAC required for clean water treatment using the Box-Behnken Design. Before the optimization process is carried out, it is necessary to select parameters that have a significant effect. The methodology in this study is divided into two main stages. The first stage involves parameter selection using Design-Expert Two-Level Factorial, with five parameters tested: liquid PAC dosage, turbidity, pH, stirring speed, and stirring time. The second stage involves optimizing parameters that have a significant effect using Design-Expert Box-Behnken. The results obtained from the parameter selection process indicate that turbidity and liquid PAC dosage have a significant effect. Optimization is carried out by entering the turbidity parameters and liquid PAC dosage as independent variables, with the response being the final turbidity. The results show that in water with turbidities of 20 NTU, 60 NTU, and 100 NTU, the optimum liquid PAC concentration is 50 ppm, with percentage reductions in turbidity of 95.72%, 97.13%, and 97.37%, respectively. BBD shows that there is a significant parameter interaction between the turbidity parameter and the liquid PAC dosage, while there is no significant interaction between the turbidity parameter and pH, and the pH parameter and the liquid PAC dosage.
Pemantapan Proses Sintesis Ligan Dibutilditiokarbamat (DBDTK) Sebagai Pengekstrak Logam Gadolinium (Gd) Berdasarkan Desain Eksperimen Diana Hendrati; Erianti Siska Purnamasari; Syulastri Effendi; Santhy Wyantuti
ALCHEMY Jurnal Penelitian Kimia Vol 14, No 2 (2018): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.14.2.15006.219-235

Abstract

Gadolinium (Gd) merupakan salah satu logam tanah jarang, dimana logam tanah jarang dapat diekstrak dari mineral salah satunya mineral monasit. Logam Gd biasanya digunakan sebagai bahan dasar contrast agent dalam dunia kesehatan. Ligan dibutilditiokarbamat mampu membentuk senyawa kompleks dengan cara mengikat logam sehingga membentuk khelat yang dapat digunakan untuk ekstraksi. Tujuan dari penelitian ini adalah memantapkan sintesis ligan dibutilditiokarbamat berdasarkan desain eksperimen dan karakterisasi kompleks antara Gd(III) dengan ligan dibutilditiokarbamat hasil sintesis. Penelitian ini diawali dengan pembuatan desain eksperimen untuk sintesis ligan dan ekstraksi Gd(III) dengan ligan, kemudian proses sintesis dan ekstraksi dilakukan sesuai dengan desain eksperimen, hasil sintesis dan ekstraksi dikarakterisasi menggunakan metode spektroskopi serta diuji kelarutannya dalam pelarut organik. Data yang diperoleh menunjukkan bahwa sintesis ligan dibutilditiokarbamat optimal pada suhu 4 °C, perbandingan dibutilamin dan karbondisulfida yaitu 1 : 3 dengan perbandingan mol ammonia terhadap dibutilamin yaitu 1 : 4, sedangkan kondisi optimal untuk ekstraksi Gd(III) dengan ligan yaitu pada pH 6, dengan perbandingan mol Gd(III) dan ligan yaitu 1 : 4 dan lama ekstraksi 60 menit. Oleh karena itu ligan dibutilditiokarbamat hasil sintesis berpotensi digunakan sebagai ekstraktan untuk ekstraksi Gd(III). Hasil prediksi ligan berdasarkan desain eksperimen yaitu sebesar 56,12% sedangkan prediksi ekstraksi Gd(III) dengan ligan hasil sintesis diperoleh sebesar 78,41%.The Consolidation of Dibutyldithiocarbamate (DBDTC) Synthesis as Gadolinium Metal Extraction Based On Experimental Design. Gadolinium (Gd) is one of the rare-earth elements, whereas rare-earth elements can be extracted from monazite. Gd is usually used as raw material for synthesizing contrast agent in medicine field. Dibuthyldithiocarbamate ligand can form a complex compound with metal. This ligand will bind a metal and then forming chelate which is used for extraction. The purpose of this research is to ensure procedure of dibuthyldithiocarbamate ligand synthesis based on the design of experiment and to study the characterization of reaction result between Gd(III) and dibuthyldithiocarbamate ligand which this ligand is synthesis result. This research begins with making design of experiment for ligand synthesis and Gd(III) extraction with ligand, then perform the process of synthesis and extraction according to the design of experiment, the result of synthesis and extraction were characterized by spectroscopy method and solubility tested in organic solvent. The data was collected indicate that the optimal condition of dibuthyldithiocarbamate ligan synthesis at 4 °C (temperature), the ratio of di-n-butylamine and carbon disulphide is 1:3 with the mole ratio of ammonia to the di-n-butylamine 1:4, while the optimal conditions for gadolinium extraction with ligand at pH 6, the mol ratio of gadolinium and ligand is 1:4 and 60 minutes extraction time. Hence, dibuthyldithiocarbamate ligand can be used as extractan for extracting Gd(III). The prediction of ligand based on the experimental design is 56.12% while the prediction of Gd(III) extraction with ligand of the synthesis result is obtained equal to 78.41%. The conclusion of this research is that the synthesis of dibuthyldithiocarbamate ligand based on the experimental design can be developed for large-scale synthesis.
Co-Authors Anni Anggraeni Ari Hardianto Diana Hendrati Effendi, Syulastri Husein Hernadi Bahti Linda Septiana Patrakomala, Nira Pratama, Intan R. Ukun M.S. Soedjanaatmadja Salimi, Sonny Santhy Wyantuti Sri Wahyuni Sri Wahyuni