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All Journal VALENSI International Journal of Renewable Energy Development Bionatura Jurnal Ekonomi & Kebijakan Publik Science and Technology Indonesia Al-Kimia Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry PENDIPA Journal of Science Education Jurnal Sains dan Kesehatan Kimia Padjadjaran
Santhy Wyantuti
Program Studi Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran, Kabupaten Sumedang, Indonesia, 45363
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Preparasi Elektrode Glassy Karbon-AuNP Dan Aplikasinya untuk Penentuan Cr(III) Secara Voltammetri dengan Pengaruh Cd(II), Cu(II), Zn(II), Dan Cr(VI) Hartati, Yeni Wahyuni; Wyantuti, Santhy; Fadhilah, Riana Adisti; Eddy, Diana Rakhmawaty
Chimica et Natura Acta Vol 5, No 2 (2017)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.883 KB) | DOI: 10.24198/cna.v5.n2.14608

Abstract

Kromium di alam berada dalam bentuk Cr(III) yang bersifat essensial dan Cr(VI) yang bersifat racun. Untuk itu diperlukan suatu metode yang sensitif dan efektif untuk menganalisis Cr(III). Metode voltammetri merupakan metode yang menjanjikan, karena dapat menggunakan elektrode kerja yang bisa secara luas dimodifikasi. Penelitian ini bertujuan untuk mempelajari pengaruh ion logam Cd(II), Zn(II), Cu(II) dan Cr(VI) serta mengetahui akurasi, limit deteksi, dan presisi dari penentuan Cr(III) secara voltammetri pulsa differensial menggunakan elektrode glassy karbon nanopartikel emas. Prosedur yang dilakukan adalah pembuatan larutan-larutan, pembuatan koloid nanopartikel emas, modifikasi elektrode glassy karbon, pengaruh ion logam Cd(II), Zn(II), Cu(II), dan Cr(VI) serta analisis Cr(III) dalam limbah tekstil secara voltammetri menggunakan elektroda glassy karbon nanopartikel emas. Dari penelitian ini didapatkan hasil modulasi amplitudo optimum 0,05 V, limit deteksi 4,6889 ppm, presisi pengukuran sebesar 98,19%, akurasi sebesar 96,17%. Adanya ion logam lain dapat mengganggu puncak arus Cr(III).
Differential Pulse Voltammetry Study for Quantitative Determination of Dysprosium (III) in Acetonitrile Solution Wyantuti, Santhy; Pratomo, Uji; Shauvina, Shauvina A; Hartati, Yeni Wahyuni; Bahti, Husein Hernandi
International Journal of Renewable Energy Development Vol 10, No 2 (2021): May 2021
Publisher : Center of Biomass & Renewable Energy, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ijred.2021.33486

Abstract

Dysprosium has gained global interest due to its key application in renewable technology, such as wind power technology. The presence of this rare earth element (REE) can be determined by several spectroscopic methods. Recently, a voltammetry method has provided an alternative method for the simple and fast detection of REEs. However, to the best of our knowledge, this experiment is usually carried out in an aqueous solvent, and the response of the REE in an organic solvent by the voltammetry method has rarely been investigated. In this research, the quantitative detection of dysprosium and dysprosium mixtures with samarium, europium and gadolinium in acetonitrile is reported by differential pulse voltammetry. A Box-Behnken design was applied to predict the optimum condition of the measurements. Three factors, namely potential deposition, deposition time and amplitude modulation, were found to significantly influence the signal under optimal conditions, which are -1.0 V, 83.64 s and 0.0929 V, respectively. The surface characterization of dysprosium deposited on a Pt surface shows better deposition under 100% acetonitrile compared to a lower concentration of acetonitrile. The evaluation in this study shows a detection limit of 0.6462 mg•L-1 and a quantitation limit of 2.1419 mg•L-1, with a precision value and recovery value of 99.97% and 93.62%, respectively.
Optimasi Sintesis Ligan Diheksilditiofosfat (DHDTP) Menggunakan Response Surface Method (RSM) Hendrati, Diana; Mardhotillah, Yulia; Anggraeni, Anni; Firdaus, M. Lutfi; Wyantuti, Santhy
PendIPA Journal of Science Education Vol 6, No 1 (2022): November - February
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.6.1.285-290

Abstract

Dihexyldithiophosphate (DHDTP) ligand is one of the homologues of dialkyldithiophosphate which is potentially better as an extractant in solvent extraction. The longer the chain in the dialkyldithophosphate compound, ability to dissolve into the organic phase is increasing compared to the shorter chain. The purpose of this study is to synthesize DHDTP ligands and find out the optimum reaction conditions to produce DHDTP ligands with optimal purity using the BoxBehnken (BBD) response surface method (RSM). DHDTP ligands are synthesized from P2S5 by reflux after addition of n-hexanol under a nitrogen gas environment. Ammonium carbonate is added to the reflux to pH 7, then evaporated to remove the solvent. The synthesized DHDTP ligand was then purified by column chromatography with a mobile phase methanol : aquadest (2.5% gradient). DHDTP ligands were examined for purity using a reverse phase HPLC with a mobile phase methanol: aquadest 3: 2. The purity of the best DHDTP synthesis results obtained was 87.34%. The DHDTP ligand formed was characterized to confirm the structure of its ligand compound by using a UV spectrophotometer in which the synthesis product showed maximum absorption at a wavelength of 212 nm and mass spectroscopy ES- with m / z 297.1687.
Modifikasi Elektrode Glassy Carbon Dengan Nanopartikel Emas Dan Aplikasinya Untuk Mendeteksi Kromium(VI) Secara Voltammetri Pulsa Differensial Santhy Wyantuti; Mahendra Permadi; Diana Hendrati; Yeni Wahyuni Hartati
Al-Kimia Vol 5 No 1 (2017): June
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v5i1.2844

Abstract

Chromium(VI) is very toxic and has been classified as a carcinogen in humans breathing. Purpose of this experiment is to analyze chromium(VI ) in voltammetry using a glassy carbon electrode modified with gold nanoparticles. Voltammetry method is a method of measuring the current generated from a given potential to the working electrode so that the electrode can be widely modified work. The procedures were produce pencil graphite electrode that was coated by gold nanoparticles and measured chromium(VI) signal. From this study obtained a detection limit of 12.70 ppm and 99.99% precision measurement and measurement of 0.8 V deposition potential, deposition time  of 120 seconds and a scan rate of 0.01 V/s optimum.
Preparasi Elektrode Glassy Karbon-AuNP Dan Aplikasinya untuk Penentuan Cr(III) Secara Voltammetri dengan Pengaruh Cd(II), Cu(II), Zn(II), Dan Cr(VI) Santhy Wyantuti; Riana Adisti Fadhilah; Diana Rakhmawaty Eddy; Yeni Wahyuni Hartati
Chimica et Natura Acta Vol 5, No 2 (2017)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.883 KB) | DOI: 10.24198/cna.v5.n2.14608

Abstract

Kromium di alam berada dalam bentuk Cr(III) yang bersifat essensial dan Cr(VI) yang bersifat racun. Untuk itu diperlukan suatu metode yang sensitif dan efektif untuk menganalisis Cr(III). Metode voltammetri merupakan metode yang menjanjikan, karena dapat menggunakan elektrode kerja yang bisa secara luas dimodifikasi. Penelitian ini bertujuan untuk mempelajari pengaruh ion logam Cd(II), Zn(II), Cu(II) dan Cr(VI) serta mengetahui akurasi, limit deteksi, dan presisi dari penentuan Cr(III) secara voltammetri pulsa differensial menggunakan elektrode glassy karbon nanopartikel emas. Prosedur yang dilakukan adalah pembuatan larutan-larutan, pembuatan koloid nanopartikel emas, modifikasi elektrode glassy karbon, pengaruh ion logam Cd(II), Zn(II), Cu(II), dan Cr(VI) serta analisis Cr(III) dalam limbah tekstil secara voltammetri menggunakan elektroda glassy karbon nanopartikel emas. Dari penelitian ini didapatkan hasil modulasi amplitudo optimum 0,05 V, limit deteksi 4,6889 ppm, presisi pengukuran sebesar 98,19%, akurasi sebesar 96,17%. Adanya ion logam lain dapat mengganggu puncak arus Cr(III).
ANALISIS PENGARUH UREA TERHADAP KESTABILAN KOMPLEKS HUMAT–BESI PADA LAPISAN TANAH Diana Rakhmawaty; Santhy Wyantuti; Dikdik Kurnia
Bionatura Vol 3, No 1 (2001): Bionatura Maret 2001
Publisher : Direktorat Sumber Daya Akademik dan Perpustakaan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Substansi organik dalam tanah dapat menyebabkan terbentuknya kompleksdengan ion logam. Asam humat yang merupakan salah satu substansi tanahberperan dalam transportasi ion-ion tersebut, sehingga dapat membentukkompleks ion logam melalui reaksi pembentukan kompleks. Penelitian inibertujuan menentukan konstanta stabilitas kompleks humat-besi danpengaruhnya dengan penambahan urea pada variasi konsentrasi terhadapkestabilan kompleks tersebut. Asam humat yang diperoleh dengan cara ekstraksidari tanah, mempunyai bobot molekul (BM) 17,987, spekturm inframerahmenunjukkan gugus karboksil, fenolik, dan karbonil. Dan spektrum ultravioletvisibelmemberi rasio warna (E4/E6) sebesar 5,47. Konstanta stabilitas humat-besisebesar 0,046. Penambahan urea akan mempengaruhi harga konstanta stabilitaskompleksnya. Penambahan urea yang akan memperbesar nilai konstantastabilitas tersebut, mempunyai nilai minimum sebesar 0,04 N.Kata Kunci: Urea, Asam humat, Kompleks humat-besi
Implementasi Kebijakan dan Realisasi Rencana Tata Ruang Kec. Garut Kota di Kab. Garut: Studi Analisis Kebijakan Lukmanul Hakim; Emma Rochima; Santhy Wyantuti
Jurnal Ekonomi & Kebijakan Publik Vol 12, No 2 (2021)
Publisher : Pusat Penelitian, Badan Keahlian DPR RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22212/jekp.v12i2.1938

Abstract

The Regional Spatial Planning Policy (RTRW) is a legal umbrella in regional development, but the policy is sometimes not based on actual conditions on the ground, resulting in an out-of-sync with the direction of spatial use. As a result, there is a gap between the spatial planning policy and its realization. This is what happened to the Garut Regency RTRW policy related to the Industrial Designated Area. This study aims to determine the suitability and gap between the Garut Regency RTRW policy and the realization, especially regarding the industrial designation area for the Sukastret leather tanning industry, Garut Kota District. The policy research method (policy research) is used in this study by synchronizing the RTRW policy with conditions in the field and with related laws and regulations combined with an Importance Performance Analysis (IPA) approach to determine the level of a gap between policy and realization. Based on the analysis results, the direction of the spatial pattern of the RTRW related to the industrial designation area in Garut Kota District has not been based on regulations, laws, and conditions in the field, so that there is asynchrony in planning. Likewise, with the direction of the spatial planning policy with actual conditions in the field, there is a gap of 42 percent. For the spatial planning policy to be effective, the existing RTRW Regional Regulation needs to be reviewed (PK) for further revision based on the relevant laws and regulations and actual conditions in the field.Keywords: spatial planning policy, leather tanning industry, gap analysisAbstrakKebijakan Rencana Tata Ruang Wilayah (RTRW) merupakan payung hukum dalam pembangunan daerah, tetapi kebijakan tersebut terkadang tidak didasarkan kepada kondisi aktual di lapangan, sehingga terjadi ketidaksinkronan dengan arahan pemanfaatan ruang. Akibatnya muncul kesenjangan antara kebijakan rencana tata ruang dengan realisasi. Hal ini yang terjadi pada Kebijakan RTRW Kabupaten Garut terkait dengan Kawasan Peruntukan Industri. Penelitian ini bertujuan untuk mengetahui kesesuaian dan kesenjangan antara Kebijakan RTRW Kabupaten Garut dengan realisasi, khususnya terkait kawasan peruntukan industri untuk industri penyamakan kulit Sukaregang, Kecamatan Garut Kota. Metode penelitian kebijakan (policy research) digunakan dalam penelitian ini dengan melakukan sinkronisasi antara Kebijakan RTRW dengan kondisi di lapangan dan dengan peraturan perundang-undangan terkait yang dikombinasi dengan pendekatan Importance Performance Analysis (IPA) untuk mengetahui tingkat kesenjangan antara kebijakan dan realisasi. Berdasarkan hasil analisis, arahan pola ruang RTRW terkait Kawasan Peruntukan Industri di Kecamatan Garut Kota belum didasarkan pada peraturan dan perundangan serta kondisi di lapangan, sehingga terjadi ketidaksinkronan dalam perencanaan. Demikian juga dengan arahan kebijakan rencana tata ruang dengan kondisi aktual di lapangan terjadi kesenjangan sebesar 42 persen. Agar kebijakan rencana tata ruang dapat berjalan efektif maka Perda RTRW yang ada perlu dilakukan peninjauan kembali (PK) untuk selanjutnya dilakukan revisi yang didasarkan kepada peraturan perundangan yang terkait serta kondisi aktual di lapangan.Kata kunci: kebijakan rencana tata ruang, industri penyamakan kulit, analisis kesenjangan
Review: Sintesis Dan Karakterisasi Nanopartikel Emas (AuNP) Serta Konjugasi AuNP Dengan DNA Dalam Aplikasi Biosensor Elektrokimia Egista Istioka Fazrin; Annisa Ilma Naviardianti; Santhy Wyantuti; Shabarni Gaffar; Yeni Wahyuni Hartati
PendIPA Journal of Science Education Vol 4, No 2 (2020): MARCH - JUNE
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (726.164 KB) | DOI: 10.33369/pendipa.4.2.21-39

Abstract

The use of gold nanoparticles (AuNP) is an appropriate one in the development of biosensors because it has a unique, strong adsorption, high biocompatibility, and large surface area. AuNPs can be synthesized by various methods with the same synthesis principle by reducing Au3+ to Au. This review explains the various methods of AuNP synthesis and their characteristics, the interaction of AuNP with biomolecules including DNA, and the application of AuNP-DNA bioconjugates in biosensors. Several applications of AuNP-DNA bioconjugates as electrochemical biosensors in the past two years are proposed in this review.
A Rapid and Sensitive Diagnosis of Typhoid Fever Based On Nested PCR-Voltammetric DNA Biosensor Using Flagellin Gene Fragment Yeni Wahyuni Hartati; Santhy Wyantuti; M. Lutfi Firdaus; Nurul Auliany; Rini Surbakti; Shabarni Gaffar
Indonesian Journal of Chemistry Vol 16, No 1 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.05 KB) | DOI: 10.22146/ijc.21182

Abstract

Typhoid fever caused by Salmonella typhi is an important issue for public health in the world. Laboratory methods for rapid and sensitive diagnosis are very important for disease management. The purpose of this study was to determine the performance of nested PCR–voltammetric DNA biosensor using flagellin gene (fla) of S. typhi as a marker. The differential pulse voltammetry using pencil graphite electrode was applied to measure the guanine oxidation signal of probes vs synthetic target stDNA and probes vs fla PCR product hybridizations. The probe DNA selectivity was examined by hybridized probes vs non-complementary sequence. The result showed that the first round nested PCR product can not be visualized by agarose electrophoresis, whereas using the voltammetric biosensor methods can be detected both for the first or second round nested PCR product. The average peak current of hybridized probe vs first and second round of PCR product was 2.32 and 1.47 μA respectively, at 0.9 V. Detection of the DNA sequences of the infectious diseases from PCR amplified real sample was also carried out using this voltammetric DNA biosensor methods.
An Electrochemical Aptasensor for the Detection of HER2 as a Breast Cancer Biomarker Based on Gold Nanoparticles-Aptamer Bioconjugates Yeni Wahyuni Hartati; Sari Syahruni; Shabarni Gaffar; Santhy Wyantuti; Muhammad Yusuf; Toto Subroto
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.67124

Abstract

Inaccurate diagnoses contributes to the high mortality rate of breast cancer. Human epidermal growth factor receptor 2 (HER2) is overexpressed in breast cancer tumors at around 20–30%. This study aims to develop an electrochemical biosensor for HER2 based on a gold nanoparticle-aptamer bioconjugate (AuNP@HER2 aptamer) and investigate the interaction between DNA aptamer and HER2 using computational methods. The bioconjugate was synthesized using maleimide and polyethylene glycol as a linker. The –NH2 group of cysteamine that modified the gold electrode can form a covalent bond with the bioconjugate maleimide. The interaction of the bioconjugated aptamer with HER2 was measured electrochemically based on the [Fe(CN)6]3−/4− redox system. The limit of detection, the linear range of HER2, precision, and accuracy in this study were 1.52 ng mL–1, 0.01 to 15.0 ng mL–1, 0.1298, and 94.06%, respectively. The structure of the DNA aptamer was modeled using mFold, Assemble2, and Chimera, with the interaction between the DNA aptamer and HER2 explored by NPDock. The modeling of the aptamer with HER2 showed that electrostatic interactions dominated the attractive forces. The resulting interaction pattern can be used as a template to improve the binding energy of the aptamer, thus providing insight into the development of aptamer-based biosensors.
Co-Authors Afrizal Mayub Amelia Shafira Anni Anggraeni, Anni Annisa Ilma Naviardianti Annisa Ilma Naviardianti Annisa Luthfiah Ari Hardianto Bahti, Husein Hernadi Dewi Handayani Diana Hendrati Diana Hendrati Diana R. Eddy Diana Rakhmawaty Diana Rakhmawaty Eddy Dikdik Kurnia Effendi, Syulastri Egista Istioka Fazrin Emma Rochima Erianti Siska Purnamasari Fadhilah, Riana Adisti Fajar Firmansyah Fauzia, Retna Fauziah, Retna Putri H Bahti, Husein H Bahti, Husen Hendrati, Diana Husein Hernadi Bahti Husein Hernandi Bahti Kharitas Insani Lena Rahmidar Lukmanul Hakim M. Lutfi Firdaus M. Lutfi Firdaus M. Lutfi Firdaus, M. Lutfi Mahendra Permadi Mardhotillah, Yulia Mardiah, Najmah Muhamad Diki Permana Muhammad Yusuf Nursaadah, Euis Nurul Auliany Nurwulanda, Salsha P Fauzia, Retna Pratomo, Uji Purba, Anita Zefanya Marchelina Putri, Syelena Prima Rahmani, Azmi Aulia Ravenna Aristantia Retna Putri Fauzia Riana Adisti Fadhilah Rini Surbakti Rizki M. Okumura Rokhmat, Launa Silky Karenindra Sari Syahruni Shabarni Gaffar Shauvina, Shauvina A Sutanto, Cindy Florencia Toto Subroto Uji Pratomo Yeni Wahyuni Hartati Zahra, Sahlaa Alifah