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Asa, Halena Meldy
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Health Professions Medicine & Pharmacology Public Health

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Molecular Docking Analysis of Anti-dengue Activity of Moringa oleifera Leaves Bioactive Compounds Riwu, Audrey Gracelia; Jannah, Insani Fitrahulil; Riwu, Katty Hendriana Priscilia; Kale, Maria Laurenci Fanny Permata; Loe, Fhady Risckhy; Asa, Halena Meldy
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23665

Abstract

Background: Dengue infection is an endemic disease in various tropical regions, including Indonesia, with increasing incidence and mortality rates, and currently, no specific therapy is available. One of the potential targets for therapeutic development is the dengue virus (DENV) envelope (E) protein, which plays a crucial role in viral replication in the host. Objective: This study aimed to explore the potential of bioactive compounds from Moringa oleifera leaves as inhibitors of the E protein through an in silico approach using molecular docking methods. Methods: A total of 17 bioactive compounds from Moringa oleifera leaf extract, based on previous studies, were obtained from the PubChem database, while the target protein structure was retrieved from the Protein Data Bank (RCSB). The drug-likeness properties of the compounds were evaluated using the SwissADME web tool. Molecular docking analysis was performed using PyRx Autodock, followed by 3D visualisation and ligand–protein interaction analysis using PyMOL and Discovery Studio 2.0. Apigenin, chrysin, kaempferol, and quercetin exhibited more negative binding affinity values than the control compound Celgosivir (-6.2 kcal/mol), with respective values of -7.4, -7.3, -7.4, and -7.3 Results: kcal/mol. These compounds also shared key amino acid residues with the control at the active site of the envelope protein. Moreover, all four compounds fulfilled the five drug-likeness criteria, indicating good oral bioavailability. Conclusion: Moringa oleifera leaves show potential as candidate anti-dengue agents through inhibition of the DENV envelope protein. Keywords: Moringa oleifera, molecular docking, dengue, antiviral, envelope protein
Depression Levels Among Nursing Students: A Descriptive Study Tunggal, Deif; syahrir, Syahrir; Asa, Halena Meldy; Jannah, Insani Fitrahulil; Riwu, Audrey Gracelia
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23698

Abstract

Background : Depression is one of the most common mental health disorders and a serious global concern, particularly among university students. Nursing students are highly vulnerable to depression due to academic pressure, professional expectations, and the challenges of clinical and social environments. Objective : This study aimed to assess the level of depression among nursing students at Nusantara Institute of Health Sciences as a foundation for developing targeted mental health interventions. Methods : This research employed a descriptive quantitative design with 55 participants selected using purposive sampling. The instrument used was the Indonesian-validated version of the Patient Health Questionnaire-9 (PHQ-9). Data were analyzed using SPSS version 20.0. The results showed that the majority of respondents were over 20 years old (52.7%), female (67.3%), lived in boarding houses (67.3%), and were self-motivated to pursue nursing education (76.4%). Based on PHQ-9 scoring, 49.1% of the participants experienced mild depression, 9.1% moderate depression, 3.6% moderately severe depression, and 38.2% had no signs of depression. Conclusion: These findings indicate that although most respondents had intrinsic motivation and independent living conditions, mild depressive symptoms remained prevalent. Therefore, early detection and preventive mental health interventions are essential to support academic success and future professionalism among nursing students. Keywords: Depression, Nursing Students, PHQ-9, Mental Health, Early Detection.
Co-Authors Audrey Gracelia Riwu Jannah, Insani Fitrahulil Kale, Maria Laurenci Fanny Permata Loe, Fhady Risckhy Riwu, Katty Hendriana Priscilia Syahrir Syahrir Tunggal, Deif