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All Journal Archives Pharmacia Cendana Medical Journal Golden Ratio of Data in Summary Jurnal Media Tropika: Jurnal Pengabdian Kepada Masyarakat Jurnal Veteriner Nusantara
Kale, Maria Laurenci Fanny Permata
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Effect of Oven Drying Temperature on The Tanin Content of Bungur (Lagerstroemia speciosa Auct. non (L.) Pers) Leaves Upa, Nurul Fatmawati Pua; Kolobani, Matias Nataniel; Wardani, Nimas Prita R.K; Kale, Maria Laurenci Fanny Permata; Tunggal, Deif
Golden Ratio of Data in Summary Vol. 4 No. 1 (2024): November - April
Publisher : Manunggal Halim Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52970/grdis.v4i1.1001

Abstract

A study was conducted on the effect of oven drying temperature on tannin content of bungur leaves (Lagerstroemia speciosa Auct. non (L.) Pers). Bungur leaves were picked, dry sorted, washed, wet sorted, and drained then oven dried at 30oC, 60(o)C, 90oC respectively. After drying, the samples were then measured for moisture content and then made into bungur leaf powder. Bungur leaf powder was then extracted by modified maceration using aquadem solvent. The extract obtained was tested qualitatively and quantitatively. Qualitative test results showed the presence of tannins. Quantitative tests using permanganometry, obtained tannin levels at drying temperatures of 30oC, 60oC, and 90oC were 7.27% ± 0.1429, 15.26% ± 1.0610, and 9.92% ± 0.7156, respectively. The highest tannin content was obtained at 60oC drying temperature.
Pengaruh Emulgator Polisorbat 60–Sorbitan 60 Terhadap Kestabilan Fisik Krim Pemutih Ekstrak Metanol Rimpang Lakka-Lakka (Curculigo orchioides Gaertn.). Kolobani, Matias Nataniel; Pua Upa, Nurul Fatmawati; Purnasari, Cahyani; Wardani, Nimas Prita Rahajengningtyas Kusuma; Kale, Maria Laurenci Fanny Permata
Archives Pharmacia Vol 7, No 1 (2025): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/ap.v7i1.8899

Abstract

Mekanisme kerja bahan pemutih salah satunya adalah menghambat aktivitas enzim tyrosinase. Ekstrak metanol rimpang Lakka-Lakka (Curculigo orchioides Gaertn.) telah diteliti dapat menghambat aktivitas enzim tyrosinase dengan nilai IC50 10,2 bpj. Oleh karena itu dapat diformulasi menjadi krim pemutih yang stabil secara fisika kimia dan aman untuk digunakan. Penelitian ini bertujuan untuk mendapatkan formulasi krim pemutih tipe a/m dari ekstrak metanol rimpang Lakka-Lakka (Curculigo orchioides Gaertn.) yang stabil secara fisik dengan emulgator Polisorbat 60-Sorbitan 60.Pada penelitian ini rimpang Lakka-Lakka dimaserasi dengan menggunakan penyari metanol kemudian diuapkan hingga diperoleh ekstrak kental, kemudian dibuat sediaan krim pemutih tipe a/m dengan menggunakan emulgator Polisorbat 60–Sorbitan 60 dengan konsentrasi 1%, 2% dan 4%. Pengujian kestabilan fisik krim meliputi pengukuran viskositas, tetesan terdispersi, pengukuran pH, dan inversi fase sebelum dan setelah kondisi penyimpanan dipercepat selama 12 jam secara bergantian pada suhu 5oC dan 35oC sebanyak 10 siklus.Pengujian kestabilan fisik memperlihatkan krim yang menggunakan emulgator Polisorbat 60-Sorbitan 60 pada konsentrasi 1%, 2% dan 4 % stabil secara fisik karena viskositas, tetes terdispersi, pH tidak mengalami perubahan yang signifikan dan krim tidak mengalami inversi fase sebelum dan setelah penyimpanan dipercepat. Formula krim yang paling stabil yaitu krim dengan emulgator Polisorbat 60-Sorbitan 60 konsentrasi 4% karena berdasarkan hasil uji viskositas krim ini paling kental, dimana semakin kental suatu krim maka semakin mampu mencegah terjadinya penggabungan tetesan terdispersi dan sedimentasi atau kriming yang menghasilkan terjadi pemisahan fase.
MEWARNAI GAMBAR HEWAN DAN BERMAIN PERAN BERSAMA ANAK PAUD TUNAS HARAPAN, DESA NAPAN Simarmata, Yohanes Timbun Raja Mangihut Ronael; Ngadha L., Maria Emerentiana; Kale, Maria Laurenci Fanny Permata; Tangkonda, Elisabet
Jurnal Media Tropika Vol 5 No 1 (2025): Jurnal Media Tropika
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/mediatropika.v5i1.19421

Abstract

Animal coloring and role-playing activities carried out at PAUD Tunas Harapan, Napan Village, aim to stimulate the cognitive, social emotional, and motor development of early childhood. Through this activity, children are invited to get to know various types of animals, develop their imagination, and train their motor skills. The results of implementing the activity show that it can improve children's ability to recognize colors, shapes, and the names of animals. In addition, children become more active and creative. Thus, it can be concluded that coloring and role-playing activities are effective learning methods for developing various aspects of early childhood development.
Molecular Docking Analysis of Anti-dengue Activity of Moringa oleifera Leaves Bioactive Compounds Riwu, Audrey Gracelia; Jannah, Insani Fitrahulil; Riwu, Katty Hendriana Priscilia; Kale, Maria Laurenci Fanny Permata; Loe, Fhady Risckhy; Asa, Halena Meldy
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23665

Abstract

Background: Dengue infection is an endemic disease in various tropical regions, including Indonesia, with increasing incidence and mortality rates, and currently, no specific therapy is available. One of the potential targets for therapeutic development is the dengue virus (DENV) envelope (E) protein, which plays a crucial role in viral replication in the host. Objective: This study aimed to explore the potential of bioactive compounds from Moringa oleifera leaves as inhibitors of the E protein through an in silico approach using molecular docking methods. Methods: A total of 17 bioactive compounds from Moringa oleifera leaf extract, based on previous studies, were obtained from the PubChem database, while the target protein structure was retrieved from the Protein Data Bank (RCSB). The drug-likeness properties of the compounds were evaluated using the SwissADME web tool. Molecular docking analysis was performed using PyRx Autodock, followed by 3D visualisation and ligand–protein interaction analysis using PyMOL and Discovery Studio 2.0. Apigenin, chrysin, kaempferol, and quercetin exhibited more negative binding affinity values than the control compound Celgosivir (-6.2 kcal/mol), with respective values of -7.4, -7.3, -7.4, and -7.3 Results: kcal/mol. These compounds also shared key amino acid residues with the control at the active site of the envelope protein. Moreover, all four compounds fulfilled the five drug-likeness criteria, indicating good oral bioavailability. Conclusion: Moringa oleifera leaves show potential as candidate anti-dengue agents through inhibition of the DENV envelope protein. Keywords: Moringa oleifera, molecular docking, dengue, antiviral, envelope protein
Applying the One Health Approach to Rabies Control in the Timor Archipelago, East Nusa Tenggara: A Literature Review on Epidemiology and Strategic Interventions Kale, Maria Laurenci Fanny Permata; Riwu, Audrey Gracelia; Simarmata, Yohanes TRMR; Wuhan, Yustinus Oswin Primajuni; Loe, Fhady Rischky
Cendana Medical Journal Vol 13 No 1 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i1.23786

Abstract

Background: Rabies remains a fatal zoonotic threat in Indonesia, particularly in East Nusa Tenggara (NTT), including Timor Island. Despite national efforts, the disease persists with rising incidence, especially in areas with high dog populations, limited vaccination coverage, and weak cross-sectoral coordination. Objective: This review aims to assess the recent epidemiological trends of rabies in Timor Island and evaluate the effectiveness of One Health implementation in controlling the outbreak. Methods: A literature review was conducted using data from 2010–2025 from sources such as WHO, FAO, Indonesian government agencies, and peer-reviewed journals. Keywords included “rabies,” “One health,” “NTT,” “Timor,” and “epidemiology.” Data were analyzed descriptively and thematically to identify gaps, risks, and strategic responses. Results: Rabies remains endemic in Timor, with more than 50,000 dog bite cases and over 80 human deaths recorded between 2023–2024. Vaccination coverage in dogs remains as low as 17.6%, and there are only 324 vaccinators for the entire province. Social and cultural factors, such as free-roaming dogs and limited public awareness, contribute significantly to transmission. Implementation of One Health remains fragmented, with low community involvement and weak surveillance integration across sectors. Conclusion: A locally adapted One health approach is urgently needed to eliminate rabies in Timor. Strengthening dog vaccination, integrating digital case reporting, engaging traditional leaders, and enforcing village-based regulations are key to effective rabies control. Keywords: Rabies, Timor Island, One health, Dog Vaccination, Community Engagement, Indonesia
Studi In Silico: Potensi Senyawa Spesifik Kulit Batang Faloak (Sterculia quadrifida R. Br) sebagai Anti-Helmintik Riwu, Audrey Gracelia; Riwu, Katty Hendriana Priscilia; Pua Upa, Nurul Fatmawati; Kale, Maria Laurenci Fanny Permata; Jannah, Insani Fitrahulil; Wuhan, Yustinus Oswin Primajuni
Jurnal Veteriner Nusantara Vol 8 No 2 (2025): Agustus, 2025
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v8i2.25038

Abstract

Helminthiasis remains a significant global public health issue, particularly in tropical and subtropical regions. The extensive and repeated use of synthetic anthelmintic agents, including albendazole and mebendazole, has contributed to the emergence of drug resistance among various parasitic species. Therefore, the exploration of plant-derived compounds with potential anthelmintic activity is urgently needed. This study investigated the potential of bioactive compounds from the stem bark of Faloak (Sterculia quadrifida R. Br) as inhibitors of the Mitochondrial Rhodoquinol-Fumarate Reductase (MRFR) protein through an in silico approach. Five compounds: epicatechin, d-catechin, catechin-(4α→8)-catechin, spinasterol, and spinasterone were analyzed, with Atpeni as the control. Drug-likeness evaluation was conducted using Lipinski’s Rule of Five, while molecular docking, visualization and molecular interaction analysis was performed using PyRx, PyMOL, and Discovery Studio. Four compounds satisfied Lipinski’s criteria, indicating favorable pharmacokinetic properties. Among them, spinasterol and spinasterone demonstrated the strongest binding affinities to MRFR (–10.1 and –9.2 kcal/mol, respectively), exceeding that of the control ligand (–6.4 kcal/mol). Hydrophobic interactions involving key residues such as Leu146, Ala149, and Val153 contributed to complex stability. These results suggest that Faloak stem bark contains promising bioactive compounds that may serve as natural anti-helmintic candidates, warranting further in vitro and in vivo validation
Knowledge, Attitudes, and Practices (KAP) of Communities toward Rabies Prevention in Indonesia: A Literature Review Kale, Maria Laurenci Fanny Permata; Riwu, Audrey Gracelia; Wuhan, Yustinus Oswin Primajuni
Jurnal Veteriner Nusantara Vol 8 No 2 (2025): Agustus, 2025
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v8i2.25098

Abstract

Rabies remains a serious zoonotic threat in Indonesia, with thousands of animal bite cases and dozens of human deaths annually. This review article aims to identify the level of community knowledge, attitudes, and practices (KAP) regarding rabies prevention in Indonesia and highlight the importance of a socio-cultural approach in supporting the national rabies elimination program. Data have been collected from scientific articles published between 2015 and 2025. Results indicate that the community’s basic knowledge about rabies is quite high, but there is still a gap between knowledge and actual practice, especially in rural and eastern Indonesia. The involvement of traditional leaders and a One Health approach is recommended to improve the effectiveness of education and compliance with rabies prevention.
Co-Authors Asa, Halena Meldy Audrey Gracelia Riwu Jannah, Insani Fitrahulil Kolobani, Matias Nataniel Loe, Fhady Rischky Loe, Fhady Risckhy Ngadha L., Maria Emerentiana Pua Upa, Nurul Fatmawati Purnasari, Cahyani Riwu, Katty Hendriana Priscilia Simarmata, Yohanes Timbun Raja Mangihut Ronael Simarmata, Yohanes TRMR Tangkonda, Elisabet Tunggal, Deif Upa, Nurul Fatmawati Pua Wardani, Nimas Prita R.K Wardani, Nimas Prita Rahajengningtyas Kusuma Wuhan, Yustinus Oswin Primajuni