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All Journal Indonesian Journal of Tropical and Infectious Disease Science and Technology Indonesia Jurnal Abadimas Adi Buana Cendana Medical Journal Jurnal Veteriner Nusantara Jurnal Pengabdian Masyarakat dan Riset Pendidikan JURNAL FLOBAMORATA MENGABDI
Audrey Gracelia Riwu
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Veterinary Other

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PKM Kader Desa Praktek Pijat Punggung pada Ibu Nifas untuk Memperlancar ASI Nurul Azizah; Riwu, Audrey Gracelia
Jurnal Abadimas Adi Buana Vol 4 No 2 (2021): Jurnal Abadimas Adi Buana
Publisher : LPPM Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/abadimas.v4.i2.a2755

Abstract

Peran kader sangat penting untuk membantu sosialisasi kegiatan untuk meningkatkan status kesehatan masyarakat, pemerintah kabupaten Sidoarjo berkomitmen meningkatkan status gizi dan ASI eksklusif dengan menetapkan perda nomor 1 tahun 2016, diharapkan seluruh masyarakat mendukung perda tersebut. Di desa Sambibulu juga mendukung tercapainya Asi eksklusif, Kader Desa Durung Bedug Candi Sidoarjo aktif dalam kegiatan dimasyarakat untuk mendukung pembentukan UKBM (upaya kesehatan berbasis masyarakat) selain posyandu terbentuk juga kelompok pundukung ASI (KP ASI) untuk membantu tercapainya ASI eksklusif. Berdasarkan survey yang telah dilakukan oleh tim pengusul pada kader didapatkan hasil bahwa cakupan ASI eksklusif masih rendah yakni 56% dari target 80% dan salah satu penyebabnya yakni karena produksi ASI kurang. Kegitaan KP ASI yang sudah berjalan namun belum terdapat upaya untuk membantu meningkatkan produksi ASI. Kader belum pernah mendapatkan pengetahuan tentang upaya untuk meningkatkan produksi ASI. Berdasarkan permasalahan tersebut tim pengusul menawarkan solusi untuk membantu mengatasi kurangnya pengetahuan dan keterampilan kader dalam meningkatkan produksi ASI. Salah satu upaya yang ditawarkan oleh tim pengusul adalah memberikan sebuah pelatihan dan pendampingan praktek pijat punggung pada kader untuk membantu meningkatkan produksi ASI. Kader Desa Durung Bedug Candi Sidoarjo termasuk kader yang mempunyai loyalitas tinggi dan aktif, sehingga tim pengusul lebih mudah untuk memberikan pelatihan dan pendampingan tentang praktek pijat punggung untuk meningkatkan produksi ASI, yang nantinya diinformasikan kepada masyarakat sebagai upaya untuk meningkatkan produksi ASI dan masyarakat dapat melakukan pijat punggung secara mandiri.
PKM Kader Desa Praktek Pijat Punggung pada Ibu Nifas untuk Memperlancar ASI Nurul Azizah; Audrey Gracelia Riwu
Jurnal Abadimas Adi Buana Vol 4 No 2 (2021): Jurnal Abadimas Adi Buana
Publisher : LPPM Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/abadimas.v4.i2.a2755

Abstract

Peran kader sangat penting untuk membantu sosialisasi kegiatan untuk meningkatkan status kesehatan masyarakat, pemerintah kabupaten Sidoarjo berkomitmen meningkatkan status gizi dan ASI eksklusif dengan menetapkan perda nomor 1 tahun 2016, diharapkan seluruh masyarakat mendukung perda tersebut. Di desa Sambibulu juga mendukung tercapainya Asi eksklusif, Kader Desa Durung Bedug Candi Sidoarjo aktif dalam kegiatan dimasyarakat untuk mendukung pembentukan UKBM (upaya kesehatan berbasis masyarakat) selain posyandu terbentuk juga kelompok pundukung ASI (KP ASI) untuk membantu tercapainya ASI eksklusif. Berdasarkan survey yang telah dilakukan oleh tim pengusul pada kader didapatkan hasil bahwa cakupan ASI eksklusif masih rendah yakni 56% dari target 80% dan salah satu penyebabnya yakni karena produksi ASI kurang. Kegitaan KP ASI yang sudah berjalan namun belum terdapat upaya untuk membantu meningkatkan produksi ASI. Kader belum pernah mendapatkan pengetahuan tentang upaya untuk meningkatkan produksi ASI. Berdasarkan permasalahan tersebut tim pengusul menawarkan solusi untuk membantu mengatasi kurangnya pengetahuan dan keterampilan kader dalam meningkatkan produksi ASI. Salah satu upaya yang ditawarkan oleh tim pengusul adalah memberikan sebuah pelatihan dan pendampingan praktek pijat punggung pada kader untuk membantu meningkatkan produksi ASI. Kader Desa Durung Bedug Candi Sidoarjo termasuk kader yang mempunyai loyalitas tinggi dan aktif, sehingga tim pengusul lebih mudah untuk memberikan pelatihan dan pendampingan tentang praktek pijat punggung untuk meningkatkan produksi ASI, yang nantinya diinformasikan kepada masyarakat sebagai upaya untuk meningkatkan produksi ASI dan masyarakat dapat melakukan pijat punggung secara mandiri.
Determination of (+)-Catechin and Antioxidant Activity in Faloak (Sterculia quadrifida R. Br) Stem Bark Infusion Audrey Gracelia Riwu; Jusak Nugraha; Djoko Agus Purwanto; Erwin Astha Triyono
Science and Technology Indonesia Vol. 8 No. 1 (2023): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.1.59-65

Abstract

Oxidative stress is a condition that can damage human cells and tissues and has been linked to a number of illnesses, including cancer, cardiovascular disease, autoimmune disorders, and neurological diseases. Oxidative stress conditions can be brought on by pollution, radiation exposure, and an unhealthy lifestyle. Antioxidants are substances that can be used to both prevent and treat oxidative stress. This study aimed to identify and quantify (+)-catechin levels and antioxidant activity of the stem bark of Sterculia quadrifida R. Br extracted by the infusion method, a method similar to traditional medicine processing generally in the community. Determination of (+)-catechin and antioxidant activity of S. quadrifida were evaluated by HPLC and DPPH assay, respectively. Quantification of (+) catechin content by HPLC system with wavelength 280 nm and antioxidant activity by spectrophotometry method with wavelength 517 nm. The results show that the mean value of (+)-catechin level was 7.786% and the IC50 value of the antioxidant activity was 51.5 ug/mL having a moderate antioxidant activity category. S. quadrifida stem bark infusion can be utilized as a medication candidate for the prevention or treatment of a variety of disorders caused by oxidative stress.
DIFFERENCES OF INTERLEUKIN-18 AND INTERLEUKIN-10 LEVELS IN RIFAMPICIN RESISTANT AND RIFAMPICIN SENSITIVE PULMONARY TUBERCULOSIS PATIENTS IN DR. SOETOMO HOSPITAL SURABAYA Riwu, Audrey Gracelia; Nugaraha, Jusak; Dachlan, Yoes Prijatna
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 2 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i2.10959

Abstract

Rifampicin is an anti-tuberculosis drug which has an efficient antimicrobial effect and the basis of a short-term treatment regimen for tuberculosis (TB) patients. Rifampicin plays an important role against the growth and slow metabolism of Bacilli M. tuberculosis. Resistance to rifampicin causes the duration of tuberculosis treatment to be longer. Interleukin-18 (IL-18) is a pro-inflammatory cytokine which plays a role in controlling the growth of M. tuberculosis through its ability to induce IFN-γ, while Interleukin-10 (IL-10) is an anti-inflammatory cytokine which plays a role in limiting tissue damage due to the inflammatory process and maintain tissue homeostasis. IL-18 and IL-10 has an important role in explaining the different degrees of inflammation in rifampicin resistant (RR) and rifampicin sensitive (RS) pulmonary tuberculosis patients. The purpose of this study is to determine different levels of IL-18 and IL-10 in new TB patients with RR and RS. This study was a retrospective cohort study with a cross-sectional design carried out from August-November 2018 in the TB-DOTS/MDR clinic at Dr. Soetomo Hospital, Surabaya. 50 research subjects were examined and grouped into two groups, namely pulmonary TB with RR (n = 25) and pulmonary TB with RS (n = 25) based on GeneXpert examination and anti-tuberculosis drug therapy ≤ 1 month. IL-18 and IL-10 were measured using the ELISA Method. Differences in IL-18 and IL-10 levels between groups were analyzed using the Mann-Whitney test. The mean level of IL-18 (pg/ml) in RR and RS pulmonary TB patients were 1273.53±749.86 and 787.96 ±589.28 respectively. The mean level of IL-10 (pg/ml) in RR and RS pulmonary TB patients were 125.25±118.32 and 128.81±135.77 repectively. The mean level of IL-18 in RR and RS pulmonary TB patients were found to have a significant difference, while the mean level of IL-10 did not have a significant difference. Keywords: Interleukin-18, Interleukin-10, Tuberculosis, Rifampicin Resistant, Rifampicin Sensitive
Peningkatan Pengetahuan dan Keterampilan Tenaga Kependidikan Melalui Pelatihan Bantuan Hidup Dasar di Program Studi Pendidikan Dokter FKKH Universitas Nusa Cendana Wardani, Nimas Prita Rahajeningtyas Kusuma; Tunggal, Deif; Syahrir, Syahrir; Jannah, Insani Fitrahulil; Riwu, Audrey Gracelia; Kale, Maria Laurenci Fany Permata; Upa, Nurul Fatmawati Pua; Purnasari, Cahyani; Kolobani, Mathias Nathaniel
Jurnal Flobamorata Mengabdi Vol. 3 No. 1 (2025): JURNAL FLOBAMORATA MENGABDI
Publisher : Program Studi Pendidikan Guru Sekolah Dasar, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Muhammadiyah Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51494/jfm.v3i1.2433

Abstract

Abstrak: Henti jantung merupakan kasus kegawatdaruratan medis dimana jantung berhenti berfungsi secara medadak sehingga menimbulkan gangguan hemodinamik tubuh hingga dapat menimbulkan kematian jika tidak ditangani segera. Tindakan bantuan hidup dasar (BHD) merupakan serangkaian tindakan pertolongan pertama yang dapat dilakukan untuk memulihkan fungsi pernapasan dan sirkulasi pada seseorang yang mengalami henti jantung. Pelatihan BHD pada tenaga kependidikan yang merupakan kelompok non-medis di lingkungan program studi Pendidikan dokter FKKH Universitas Nusa Cendana bertujuan untuk meningkatkan kapabilitas pegawai dalam melakukan pertolongan pertama serta meningkatkan kesiapsiagaan pegawai dalam kondisi kegawatdaruratan kejadian henti jantung terutama di lingkungan kerja. Metode yang digunakan adalah pelatihan kepada 20 tenaga kependidikan dengan menggabungkan teori, diskusi interaktif, serta praktik simulasi. Hasil dari pelatihan didapatkan peningkatan pengetahuan diukur dari nilai post-test yang jauh lebih baik dibandingkan nilai pre-test. Selain itu, didapatkan peningkatan keterampilan dan kepercayaan diri dari peserta dalam melakukan tindakan BHD pada kasus henti jantung. Kesimpulannya, kegiatan pelatihan BHD bagi tenaga kependidikan di lingkungan program studi Pendidikan Dokter, FKKH Universitas Nusa Cendana terbukti efektif dalam meningkatkan pengetahuan dan keterampilan peserta pelatihan.
Molecular Docking Analysis of Anti-dengue Activity of Moringa oleifera Leaves Bioactive Compounds Riwu, Audrey Gracelia; Jannah, Insani Fitrahulil; Riwu, Katty Hendriana Priscilia; Kale, Maria Laurenci Fanny Permata; Loe, Fhady Risckhy; Asa, Halena Meldy
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23665

Abstract

Background: Dengue infection is an endemic disease in various tropical regions, including Indonesia, with increasing incidence and mortality rates, and currently, no specific therapy is available. One of the potential targets for therapeutic development is the dengue virus (DENV) envelope (E) protein, which plays a crucial role in viral replication in the host. Objective: This study aimed to explore the potential of bioactive compounds from Moringa oleifera leaves as inhibitors of the E protein through an in silico approach using molecular docking methods. Methods: A total of 17 bioactive compounds from Moringa oleifera leaf extract, based on previous studies, were obtained from the PubChem database, while the target protein structure was retrieved from the Protein Data Bank (RCSB). The drug-likeness properties of the compounds were evaluated using the SwissADME web tool. Molecular docking analysis was performed using PyRx Autodock, followed by 3D visualisation and ligand–protein interaction analysis using PyMOL and Discovery Studio 2.0. Apigenin, chrysin, kaempferol, and quercetin exhibited more negative binding affinity values than the control compound Celgosivir (-6.2 kcal/mol), with respective values of -7.4, -7.3, -7.4, and -7.3 Results: kcal/mol. These compounds also shared key amino acid residues with the control at the active site of the envelope protein. Moreover, all four compounds fulfilled the five drug-likeness criteria, indicating good oral bioavailability. Conclusion: Moringa oleifera leaves show potential as candidate anti-dengue agents through inhibition of the DENV envelope protein. Keywords: Moringa oleifera, molecular docking, dengue, antiviral, envelope protein
Depression Levels Among Nursing Students: A Descriptive Study Tunggal, Deif; syahrir, Syahrir; Asa, Halena Meldy; Jannah, Insani Fitrahulil; Riwu, Audrey Gracelia
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23698

Abstract

Background : Depression is one of the most common mental health disorders and a serious global concern, particularly among university students. Nursing students are highly vulnerable to depression due to academic pressure, professional expectations, and the challenges of clinical and social environments. Objective : This study aimed to assess the level of depression among nursing students at Nusantara Institute of Health Sciences as a foundation for developing targeted mental health interventions. Methods : This research employed a descriptive quantitative design with 55 participants selected using purposive sampling. The instrument used was the Indonesian-validated version of the Patient Health Questionnaire-9 (PHQ-9). Data were analyzed using SPSS version 20.0. The results showed that the majority of respondents were over 20 years old (52.7%), female (67.3%), lived in boarding houses (67.3%), and were self-motivated to pursue nursing education (76.4%). Based on PHQ-9 scoring, 49.1% of the participants experienced mild depression, 9.1% moderate depression, 3.6% moderately severe depression, and 38.2% had no signs of depression. Conclusion: These findings indicate that although most respondents had intrinsic motivation and independent living conditions, mild depressive symptoms remained prevalent. Therefore, early detection and preventive mental health interventions are essential to support academic success and future professionalism among nursing students. Keywords: Depression, Nursing Students, PHQ-9, Mental Health, Early Detection.
Applying the One Health Approach to Rabies Control in the Timor Archipelago, East Nusa Tenggara: A Literature Review on Epidemiology and Strategic Interventions Kale, Maria Laurenci Fanny Permata; Riwu, Audrey Gracelia; Simarmata, Yohanes TRMR; Wuhan, Yustinus Oswin Primajuni; Loe, Fhady Rischky
Cendana Medical Journal Vol 13 No 1 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i1.23786

Abstract

Background: Rabies remains a fatal zoonotic threat in Indonesia, particularly in East Nusa Tenggara (NTT), including Timor Island. Despite national efforts, the disease persists with rising incidence, especially in areas with high dog populations, limited vaccination coverage, and weak cross-sectoral coordination. Objective: This review aims to assess the recent epidemiological trends of rabies in Timor Island and evaluate the effectiveness of One Health implementation in controlling the outbreak. Methods: A literature review was conducted using data from 2010–2025 from sources such as WHO, FAO, Indonesian government agencies, and peer-reviewed journals. Keywords included “rabies,” “One health,” “NTT,” “Timor,” and “epidemiology.” Data were analyzed descriptively and thematically to identify gaps, risks, and strategic responses. Results: Rabies remains endemic in Timor, with more than 50,000 dog bite cases and over 80 human deaths recorded between 2023–2024. Vaccination coverage in dogs remains as low as 17.6%, and there are only 324 vaccinators for the entire province. Social and cultural factors, such as free-roaming dogs and limited public awareness, contribute significantly to transmission. Implementation of One Health remains fragmented, with low community involvement and weak surveillance integration across sectors. Conclusion: A locally adapted One health approach is urgently needed to eliminate rabies in Timor. Strengthening dog vaccination, integrating digital case reporting, engaging traditional leaders, and enforcing village-based regulations are key to effective rabies control. Keywords: Rabies, Timor Island, One health, Dog Vaccination, Community Engagement, Indonesia
Studi In Silico: Potensi Senyawa Spesifik Kulit Batang Faloak (Sterculia quadrifida R. Br) sebagai Anti-Helmintik Riwu, Audrey Gracelia; Riwu, Katty Hendriana Priscilia; Pua Upa, Nurul Fatmawati; Kale, Maria Laurenci Fanny Permata; Jannah, Insani Fitrahulil; Wuhan, Yustinus Oswin Primajuni
Jurnal Veteriner Nusantara Vol 8 No 2 (2025): Agustus, 2025
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v8i2.25038

Abstract

Helminthiasis remains a significant global public health issue, particularly in tropical and subtropical regions. The extensive and repeated use of synthetic anthelmintic agents, including albendazole and mebendazole, has contributed to the emergence of drug resistance among various parasitic species. Therefore, the exploration of plant-derived compounds with potential anthelmintic activity is urgently needed. This study investigated the potential of bioactive compounds from the stem bark of Faloak (Sterculia quadrifida R. Br) as inhibitors of the Mitochondrial Rhodoquinol-Fumarate Reductase (MRFR) protein through an in silico approach. Five compounds: epicatechin, d-catechin, catechin-(4α→8)-catechin, spinasterol, and spinasterone were analyzed, with Atpeni as the control. Drug-likeness evaluation was conducted using Lipinski’s Rule of Five, while molecular docking, visualization and molecular interaction analysis was performed using PyRx, PyMOL, and Discovery Studio. Four compounds satisfied Lipinski’s criteria, indicating favorable pharmacokinetic properties. Among them, spinasterol and spinasterone demonstrated the strongest binding affinities to MRFR (–10.1 and –9.2 kcal/mol, respectively), exceeding that of the control ligand (–6.4 kcal/mol). Hydrophobic interactions involving key residues such as Leu146, Ala149, and Val153 contributed to complex stability. These results suggest that Faloak stem bark contains promising bioactive compounds that may serve as natural anti-helmintic candidates, warranting further in vitro and in vivo validation
Knowledge, Attitudes, and Practices (KAP) of Communities toward Rabies Prevention in Indonesia: A Literature Review Kale, Maria Laurenci Fanny Permata; Riwu, Audrey Gracelia; Wuhan, Yustinus Oswin Primajuni
Jurnal Veteriner Nusantara Vol 8 No 2 (2025): Agustus, 2025
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v8i2.25098

Abstract

Rabies remains a serious zoonotic threat in Indonesia, with thousands of animal bite cases and dozens of human deaths annually. This review article aims to identify the level of community knowledge, attitudes, and practices (KAP) regarding rabies prevention in Indonesia and highlight the importance of a socio-cultural approach in supporting the national rabies elimination program. Data have been collected from scientific articles published between 2015 and 2025. Results indicate that the community’s basic knowledge about rabies is quite high, but there is still a gap between knowledge and actual practice, especially in rural and eastern Indonesia. The involvement of traditional leaders and a One Health approach is recommended to improve the effectiveness of education and compliance with rabies prevention.
Co-Authors Asa, Halena Meldy Djoko Agus Purwanto Erwin Astha Triyono Jannah, Insani Fitrahulil Jusak Nugraha Kale, Maria Laurenci Fanny Permata Kale, Maria Laurenci Fany Permata Kolobani, Mathias Nathaniel Loe, Fhady Rischky Loe, Fhady Risckhy Muhajirin Dean Nugaraha, Jusak Nurul Azizah Nurul Azizah Nurul Azizah Nurul Fatmawati Pua Upa Pua Upa, Nurul Fatmawati Purnasari, Cahyani Riwu, Katty Hendriana Priscilia Simarmata, Yohanes TRMR Syahrir Syahrir Tunggal, Deif Upa, Nurul Fatmawati Pua Wardani, Nimas Prita Rahajeningtyas Kusuma Wuhan, Yustinus Oswin Primajuni Yoes Prijatna Dachlan