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All Journal Jurnal Pemuda Jurnal Studi Pemuda Medicinus : Jurnal Kedokteran
Welliangan, Ariyani Sudhamma
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Arts Humanities Medicine & Pharmacology Public Health Social Sciences

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Comparative Effectiveness of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Heart Failure: A Systematic Review Putri, Evira Agustina; Putri, Adinda Wafdani; Andreago; Welliangan, Ariyani Sudhamma; Guantoro, Vincent; Mardiah, Harisa
Medicinus Vol. 14 No. 3 (2025): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i3.10164

Abstract

Background: Heart failure (HF) affects over 64 million individuals globally and is associated with high morbidity and mortality, particularly in patients with type 2 diabetes mellitus (T2DM). Sodium-glucose co-transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are emerging therapies with reported cardiovascular benefits. However, their comparative efficacy in HF-specific outcomes remains unclear. This systematic review aimed to assess and compare the safety and efficacy of SGLT2 inhibitors and GLP-1 RAs in patients with HF. Methods: We systematically searched PubMed, EMBASE, and Scopus up to 1 May 2025 for randomized controlled trials (RCTs) evaluating SGLT2 inhibitors or GLP-1 RAs in adults with HF. Primary outcomes included all-cause and cardiovascular mortality; secondary outcomes included HF hospitalization and major adverse cardiovascular events (MACE). Risk of bias was assessed using the Cochrane RoB 2 tool and certainty of evidence with the GRADE approach. Result: Fourteen RCTs comprising 30,867 patients (52.2% female; 63.2% with T2DM) were included. SGLT2 inhibitors significantly reduced cardiovascular mortality (RR: 0.85, 95% CI: 0.78–0.93, p < 0.001, I² = 14%), all-cause mortality (RR: 0.88, 95% CI: 0.81–0.95, p = 0.002, I² = 21%), and HF hospitalizations (RR: 0.72, 95% CI: 0.67–0.77, p < 0.001, I² = 0%). GLP-1 RAs did not demonstrate significant effects on these outcomes. Overall risk of bias was low to moderate; GRADE certainty ranged from moderate to high. Conclusions: SGLT2 inhibitors provide consistent reductions in mortality and hospitalization in HF patients across glycemic statuses. GLP-1 RAs showed limited benefit in HF-specific outcomes, supporting the preferential use of SGLT2 inhibitors in HF treatment strategies.
Hubungan antara Intensitas Penggunaan Media Sosial dan Kesehatan Mental pada Remaja dan Dewasa Muda: A Systematic Review of Empirical Quantitative Studies Kosen, Yosua Darmadi; Jannah, Syarifah Miftahul; Apriadi, Adis; Asyum, Muhammad Arifial; Faustin, Amadea Jovita Miko; Nurfitri, Rizalya Zahra; Christanti, Yohana; Ryanto, Alyssa Feodora; Hersan, Kevin; Welliangan, Ariyani Sudhamma; Wahyudi, Chandra; Adiwijaya, Wilma; Tondang, Hana Grace
Jurnal Studi Pemuda Vol 14, No 1 (2025): Kaum Muda, Identitas, dan Transformasi Sosial di Era Digital
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/studipemudaugm.111681

Abstract

The growing prevalence of social media use among adolescents and young adults has raised concerns about its potential impact on mental health. This study was guided by the hypothesis that higher intensity of social media engagement is associated with adverse psychological outcomes. A systematic literature review was performed in accordance with PRISMA 2020 guidelines by searching Cochrane Library, PubMed, Scopus, Web of Science, Proquest, and Google Scholar for empirical studies published between 2015–2025 involving individuals aged 12–24 years. Twenty eligible articles were analysed, encompassing cross-sectional, longitudinal, and randomized controlled trial designs. The synthesis revealed that excessive social media use, particularly exceeding three to four hours daily, was consistently linked to depression, anxiety, sleep disturbances, emotional dysregulation, loneliness, and increased risk of self-harm or suicidal ideation. Key mediating mechanisms included fear of missing out, negative social comparison, cyberbullying, and poor sleep quality. Conversely, evidence from randomized controlled trials demonstrated that limiting usage to approximately 30 minutes per day or temporary abstinence significantly improved well-being, life satisfaction, and psychological resilience. These findings highlight the importance of targeted preventive strategies, including digital literacy, healthy lifestyle promotion, and structured time management, to mitigate the negative consequences of excessive social media use in adolescents and young adults.
Hubungan antara Intensitas Penggunaan Media Sosial dan Kesehatan Mental pada Remaja dan Dewasa Muda: A Systematic Review of Empirical Quantitative Studies Kosen, Yosua Darmadi; Jannah, Syarifah Miftahul; Apriadi, Adis; Asyum, Muhammad Arifial; Faustin, Amadea Jovita Miko; Nurfitri, Rizalya Zahra; Christanti, Yohana; Ryanto, Alyssa Feodora; Hersan, Kevin; Welliangan, Ariyani Sudhamma; Wahyudi, Chandra; Adiwijaya, Wilma; Tondang, Hana Grace
Jurnal Studi Pemuda Vol 14, No 1 (2025): Kaum Muda, Identitas, dan Transformasi Sosial di Era Digital
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/studipemudaugm.111681

Abstract

The growing prevalence of social media use among adolescents and young adults has raised concerns about its potential impact on mental health. This study was guided by the hypothesis that higher intensity of social media engagement is associated with adverse psychological outcomes. A systematic literature review was performed in accordance with PRISMA 2020 guidelines by searching Cochrane Library, PubMed, Scopus, Web of Science, Proquest, and Google Scholar for empirical studies published between 2015–2025 involving individuals aged 12–24 years. Twenty eligible articles were analysed, encompassing cross-sectional, longitudinal, and randomized controlled trial designs. The synthesis revealed that excessive social media use, particularly exceeding three to four hours daily, was consistently linked to depression, anxiety, sleep disturbances, emotional dysregulation, loneliness, and increased risk of self-harm or suicidal ideation. Key mediating mechanisms included fear of missing out, negative social comparison, cyberbullying, and poor sleep quality. Conversely, evidence from randomized controlled trials demonstrated that limiting usage to approximately 30 minutes per day or temporary abstinence significantly improved well-being, life satisfaction, and psychological resilience. These findings highlight the importance of targeted preventive strategies, including digital literacy, healthy lifestyle promotion, and structured time management, to mitigate the negative consequences of excessive social media use in adolescents and young adults.
Co-Authors Adiwijaya, Wilma Andreago Apriadi, Adis Asyum, Muhammad Arifial Christanti, Yohana Faustin, Amadea Jovita Miko Guantoro, Vincent Hersan, Kevin Jannah, Syarifah Miftahul Kosen, Yosua Darmadi Mardiah, Harisa Nurfitri, Rizalya Zahra Putri, Adinda Wafdani Putri, Evira Agustina Ryanto, Alyssa Feodora Tondang, Hana Grace Wahyudi, Chandra