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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Biomedika dan Kesehatan
Adiwignyo, Dandy Drestanto
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation between Characteristics and Knowledge about Osteoporosis in Patients with Fragility Fractures at Saiful Anwar General Hospital Irsan, Istan Irmansyah; Hariyanti, Tita; Isma, Satria Pandu Persada; Adiwignyo, Dandy Drestanto; Hamdani, Romi
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.24302

Abstract

Osteoporosis is a global health issue. Fragility fractures, which occur due to minor trauma, are one of the serious consequences of osteoporosis. Aims: This study investigates the correlation between demographic characteristics and the level of knowledge about osteoporosis in patients with fragility fractures. This research used a descriptive design with a cross-sectional approach. The data was gathered through validated and reliable questionnaires. Respondents were patients with fragility fractures treated at Dr. Saiful Anwar General Hospital, Malang. Data analysis was performed using statistical tests to evaluate the correlation between age, gender, and knowledge about osteoporosis. The analysis revealed significant gender differences in osteoporosis knowledge (p-value = 0.037) but no substantial age-related disparities (p-value = 0.194). There were no significant differences in nutritional status based on gender (p-value = 0.881) or age (p-value = 0.521). Similarly, medication adherence showed no significant variance by gender (p-value = 0.883) or age (p-value = 0.589). Lastly, the understanding of osteoporosis did not significantly differ by gender (p-value = 0.467) or age (p-value = 0.782). In conclusion, the study reveals a significant gender disparity in osteoporosis knowledge, highlighting the need for tailored educational interventions and physician initiatives to ensure equitable awareness across diverse demographic groups.
Pengaruh Nitrogen Cair terhadap Morfologi dan Jumlah Fibroblas pada Tendon Patela Tikus Wistar Jantan Isma, Satria Pandu Persada; Norahmawati, Eviana; Irsan, Istan Irmansyah; Asmiragani, Syaifullah; Phatama, Krisna Yuarno; Adiwignyo, Dandy Drestanto; Pratama, Yudit Alfa`
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.308-316

Abstract

Background Cryoablation with liquid nitrogen has shown promise in treating bone sarcomas, but its effects on fibroblast morphology and viability in ligament tissue remain unclear. This study aims to evaluate the effects of liquid nitrogen on fibroblasts in the patellar tendon ligament of male Wistar rats. Methods This experimental study used 24 male Wistar rats (6 months old, 300-400 grams), randomly divided into four groups. The control group was not exposed to liquid nitrogen, while the experimental groups were exposed for 1, 5, and 10 minutes, respectively. After 7 days of acclimatization, the rats were exposed to liquid nitrogen and then euthanized. The patellar tendon ligaments were collected for histological analysis, stained with Hematoxylin-Eosin, and examined under a microscope. Statistical analysis was performed using One-Way ANOVA, followed by Tukey post hoc tests to determine significant differences among exposure times. Results Significant changes in fibroblast morphology and count were observed with increasing exposure time. One-way ANOVA revealed significant differences (p < 0.001) in fibroblast count and morphological alterations across exposure groups. Tukey post hoc tests showed that a 10-minute exposure resulted in substantial reductions in fibroblast count and viability, accompanied by progressive morphological changes as exposure time increased. Discussion Exposure to liquid nitrogen significantly affects fibroblast cells, and longer exposure times lead to more severe cellular damage. Exposure duration should be carefully controlled during cryotherapy to optimize therapeutic benefits. Conclusions Exposure to liquid nitrogen adversely affects fibroblast cells in the patellar tendon ligament, with prolonged exposure resulting in decreased cell viability and morphological changes.
Co-Authors Asmiragani, Syaifullah Eviana Norahmawati Hamdani, Romi Irsan, Istan Irmansyah Phatama, Krisna Yuarno Pratama, Yudit Alfa` Satria Pandu Persada Isma Tita Hariyanti