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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Biomedika dan Kesehatan
Adiwignyo, Dandy Drestanto
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation between Characteristics and Knowledge about Osteoporosis in Patients with Fragility Fractures at Saiful Anwar General Hospital Irsan, Istan Irmansyah; Hariyanti, Tita; Isma, Satria Pandu Persada; Adiwignyo, Dandy Drestanto; Hamdani, Romi
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.24302

Abstract

Osteoporosis is a global health issue. Fragility fractures, which occur due to minor trauma, are one of the serious consequences of osteoporosis. Aims: This study investigates the correlation between demographic characteristics and the level of knowledge about osteoporosis in patients with fragility fractures. This research used a descriptive design with a cross-sectional approach. The data was gathered through validated and reliable questionnaires. Respondents were patients with fragility fractures treated at Dr. Saiful Anwar General Hospital, Malang. Data analysis was performed using statistical tests to evaluate the correlation between age, gender, and knowledge about osteoporosis. The analysis revealed significant gender differences in osteoporosis knowledge (p-value = 0.037) but no substantial age-related disparities (p-value = 0.194). There were no significant differences in nutritional status based on gender (p-value = 0.881) or age (p-value = 0.521). Similarly, medication adherence showed no significant variance by gender (p-value = 0.883) or age (p-value = 0.589). Lastly, the understanding of osteoporosis did not significantly differ by gender (p-value = 0.467) or age (p-value = 0.782). In conclusion, the study reveals a significant gender disparity in osteoporosis knowledge, highlighting the need for tailored educational interventions and physician initiatives to ensure equitable awareness across diverse demographic groups.
Pengaruh Nitrogen Cair terhadap Morfologi dan Jumlah Fibroblas pada Tendon Patela Tikus Wistar Jantan Isma, Satria Pandu Persada; Norahmawati, Eviana; Irsan, Istan Irmansyah; Asmiragani, Syaifullah; Phatama, Krisna Yuarno; Adiwignyo, Dandy Drestanto; Pratama, Yudit Alfa`
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Introduction: Cryoablation with liquid nitrogen has shown promise in treating bone sarcomas, but its effect on fibroblast morphology and viability in ligament tissues remains unclear. This study aims to evaluate the impact of liquid nitrogen on fibroblasts in the patellar tendon ligament of male Wistar rats. Methods: This experimental study utilized 28 male Wistar rats (6 months old, 300-400 grams) that were randomly divided into four groups. The control group was not exposed to liquid nitrogen, while the experimental groups were exposed to liquid nitrogen for 1, 5, and 10 minutes. After a 7-day acclimatization, the rats were exposed to liquid nitrogen and euthanized. The patellar tendon ligaments were collected for histological analysis, stained with Hematoxylin-Eosin, and examined under a microscope. Statistical analysis was performed using One-Way ANOVA, followed by Tukey post hoc tests to determine the significant differences between the exposure times. Results: Significant changes were observed in fibroblast morphology and count with increasing exposure times. One-way ANOVA analysis revealed significant differences (p < 0.001) in fibroblast count and morphological alterations across exposure groups. Tukey post hoc tests revealed that 10-minute exposure resulted in substantial reductions in fibroblast count and viability, accompanied by progressive morphological changes as exposure time increased. Discussion: Liquid nitrogen exposure significantly impacts fibroblast cells, with longer exposure times causing more severe cellular damage. The exposure duration should be carefully controlled in cryotherapy to optimize therapeutic benefits. Conclusion: Exposure to liquid nitrogen adversely affects fibroblast cells in the patellar tendon ligament, with prolonged exposure resulting in decreased cesll viability and morphological changes.
Co-Authors Asmiragani, Syaifullah Eviana Norahmawati Hamdani, Romi Irsan, Istan Irmansyah Phatama, Krisna Yuarno Pratama, Yudit Alfa` Satria Pandu Persada Isma Tita Hariyanti