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All Journal Jurnal Kreativitas PKM Jurnal Kolaboratif Sains Usadha Abdi Samulang : Jurnal Pengabdian Kepada Masyarakat Journal of Creative Power and Ambition (JCPA)
Gede Agus Ari Tirtayasa
Fakultas Farmasi Universitas Mahasaraswati Denpasar
Religion Agriculture, Biological Sciences & Forestry Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Identifikasi Senyawa Fitokimia dan Uji Aktivitas Antioksidan pada Cascara (Coffea arabica L.) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Handani, Dewa Ayu Sri; Dewi, Ni Luh Kade Arman Anita; Megawati, Fitria; Tirtayasa, Gede Agus Ari
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.12181

Abstract

Cascara refers to the dried husk of coffee cherries. It has garnered significant attention in recent research due to its phytochemical composition and potential health benefits. Several studies have highlighted the presence of bioactive compounds and the antioxidant activity exhibited by cascara. This study aims to investigate the phytochemical content and antioxidant potential of cascara. The cascara was extracted using the maceration method with 96% ethanol, followed by phytochemical screening for alkaloids, flavonoids, tannins, saponins, terpenoids, steroids, and quinones using standard color reactions in test tubes. Antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, with ascorbic acid as a reference compound. The phytochemical profile of the extract was identified using gas chromatography-mass spectrometry (GC-MS). The findings indicated that cascara contains alkaloids, flavonoids, tannins, saponins, and triterpenoids. GC-MS analysis identified caffeine, hexadecanoic acid (methyl ester), and hexadecanoic acid (ethyl ester) as the predominant compounds in cascara. The antioxidant activity test using the DPPH method demonstrated that the ethanol extract of cascara possesses moderate antioxidant potential, with an average IC50 value of 108.49 ± 1.28 ppm. Ascorbic acid, the reference compound used in this study, yielded an IC50 of 2.53 ppm, categorized as very strong. This research underscores cascara’s potential as a valuable source of antioxidants with significant health benefits, influenced by geographic factors affecting its bioactive compound profile. Consequently, cascara holds promise for further development as a raw material for functional health-promoting products.
Peningkatan Produktivitas BumDesa Melalui Pendampingan Perijinan dan pemasaran Produk UMKM Unggulan Desa Pecatu, Bali Sasadara, Maria Malida; Yuda, Putu Era Sandhi Kusuma; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Tirtayasa, Gede Agus Ari
ABDI SAMULANG: Jurnal Pengabdian Kepada Masyarakat Vol 5 No 1 (2026): JANUARI| ABDI SAMULANG
Publisher : Yayasan Habiburrahman Jamalu Bina Ummat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61477/abdisamulang.v5i1.84

Abstract

UMKM Boga Sari Pecatu is a community-based small enterprise fostered by BUMDesa Catu Kwero Sedana Pecatu, specializing in the production of herbal goods. To enhance the productivity of the BUMDesa, the village has designated several flagship products for wider market development, including instant ginger powder to be produced by UMKM Boga Sari Pecatu. Although the UMKM has produced several items, it faces key challenges such as the absence of production permits, limited production facilities that hinder scale‐up, the lack of product branding, and the absence of standardized bookkeeping practices. Through this community service initiative, the implementing team carried out several programs to address these issues, including assistance in fulfilling PIRT registration requirements, procurement of a ginger grater machine to support larger‐scale instant ginger powder production, development of a UMKM logo along with packaging design and labelling, and training on simple bookkeeping practices applicable to small enterprises. The program, conducted by the Faculty of Pharmacy, Universitas Mahasaraswati Denpasar, proceeded smoothly and according to plan. The major focuses included permit facilitation, provision of production equipment, and strengthening of product branding through the development of logos and packaging labels. The outcomes indicate improved partner understanding of PIRT procedures and benefits, although the permit issuance process is still ongoing. In terms of branding, the UMKM now possesses a new logo and compliant packaging label design, enhancing product readiness for broader distribution. Bookkeeping training likewise improved partner knowledge, as reflected in the differences between pre-test and post-test scores
The use of Red Onion (Allium Cepa L.) Skin Extract as an Antioxidant and Anti-Inflammatory in Rats: A Literature Review Study Gede Agus Ari Tirtayasa; Maria Malida Vernandes Sasadara; Putu Era Sandhi Kusuma Yuda; Erna Cahyaningsih; Ni Luh Kade Arman Anita Dewi
Journal of Creative Power and Ambition (JCPA) Vol. 4 No. 01 (2026): Journal of Creative Power and Ambition (JCPA)
Publisher : CV Edujavare Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70610/jcpa.v4i01.1145

Abstract

Red onion peel (Allium cepa L.) is an agricultural by-product that contains high levels of bioactive compounds, particularly flavonoids and quercetin, which are known to possess antioxidant and anti-inflammatory properties. This systematic literature review aims to analyze the scientific evidence regarding the effects of red onion peel extract on antioxidant and anti-inflammatory activities in mouse models. Data were collected from international databases and selected based on relevance to in vivo and in vitro studies published between 2020 and 2025. The findings indicate that red onion peel extract significantly enhances antioxidant defense mechanisms by increasing the activity of superoxide dismutase (SOD), catalase, and total antioxidant capacity (ORAC), while reducing oxidative stress markers such as nitric oxide (NO) and inducible nitric oxide synthase (iNOS). In addition, the extract exhibits strong anti-inflammatory effects through the suppression of pro-inflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, as well as inhibition of key signaling pathways such as JAK-STAT, NF-κB, and NLRP3/caspase-1. The effectiveness of the extract is influenced by dosage, duration of administration, and extraction method, with higher doses and longer exposure generally producing stronger biological effects. Overall, red onion peel extract shows promising potential as a natural source of antioxidant and anti-inflammatory agents for nutraceutical and therapeutic applications.
Aktivitas Farmakologi Daun Kelor (Moringa oleifera) Sebagai Antiinflamasi (Pharmacological Activity of Moringa Leaves (Moringa oleifera) as an Anti-Inflammatory): Pharmacological Activity of Moringa Leaves (Moringa oleifera) as an Anti-Inflammatory Ni Luh Desy Rupadani; I Gusti Ayu Intan Puspita Dewi; Gede Agus Ari Tirtayasa
Jurnal Kolaboratif Sains (Special Issue) - Jurnal Kolaboratif Sains (JKS) - Januari 2026
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v9i1.10198

Abstract

Daun kelor (Moringa oleifera) telah lama dikenal sebagai obat tradisional di masyarakat. Daun kelor memiliki banyak aktivitas farmakologi salah satunya sebagai antiinflamasi. Penelitian mengenai aktivitas antiinflamasi daun kelor sudah banyak dilakukan, baik secara in vitro maupun in vivo. Terdapat beberapa mekanisme antiinflamasi daun kelor diantaranya penghambatan sintesis prostaglandin, menekan sitokin pro inflamasi, penghambatan denaturasi protein. Tinjauan pustaka ini bertujuan untuk mengevaluasi secara komprehensif bukti penelitian terkini mengenai mekanisme kerja antiinflamasi daun kelor. Pencarian literatur menggunakan database nasional dan internasional seperti pubmed, google scholar, scopus dan lain sebagainya. Uji in vivo menunjukkan potensi daun kelor untuk dikembangkan menjadi sediaan farmasi bahkan dapat dikembangkan untuk dilakukan pengujian klinis kepada manusia.
Uji Toksisitas Ekstrak Etanol Bunga Kenop (Gomphrena globosa Linn.) Dengan Metode Brine Shirp LethalIty Test (BSLT) Made Darmawan; Erna Cahyaningsih; I Wayan Surya Rahadi; Putu Era Sandhi Kusuma Yuda; Gede Agus Ari Tirtayasa; Ni Luh Kade Arman Anita Dewi
Usadha Vol 5 No 2 (2026): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v5i2.14789

Abstract

Advances in healthcare and drug development have continued to encourage the exploration of bioactive compounds derived from natural sources. One plant with potential for further development is globe amaranth (Gomphrena globosa Linn.). This study aimed to evaluate the toxicity of the ethanolic extract of globe amaranth (G. globosa) flowers based on its LC₅₀ value using the Brine Shrimp Lethality Test (BSLT) method. This study was conducted as a laboratory-based experimental study. Data were obtained from laboratory testing and supported by a literature review. Globe amaranth (G. globosa) flower samples were obtained from farmers in Sanur, Denpasar, Bali. Extraction was performed by maceration using 80% ethanol, followed by phytochemical screening to identify the presence of flavonoids. Toxicity testing was conducted using Artemia salina larvae, and mortality data were subsequently analysed using probit analysis and linear regression to determine the LC₅₀ value. Phytochemical screening showed that the ethanolic extract of G. globosa flowers tested positive for flavonoids. The regression equation obtained was y = 13589x + 1.7924, with a correlation coefficient (R²) of 0.9707 and an LC₅₀ value of 228.620 µg/mL . Based on these findings, the ethanolic extract of G. globosa flowers exhibited toxic effects against A. salina and was classified as toxic according to the BSLT method. These findings indicate the presence of biological activity in the extract and may provide a basis for further studies investigating its pharmacological potential and safety profile.
Socialization of Anthocyanin Content of Purple Sweet Potato Tubers in Bongkasa Pertiwi Village to Increase Public Knowledge I Wayan Putu Sutirta Yasa; I Made Jawi; A.A Ngurah Subawa; Ida Bagus Putra Manuaba; Komang Januartha Putra Pinatih; Putu Ayu Swandewi Astuti; I Gede Peri Arista; Gede Agus Ari Tirtayasa; Made Rendra Wisnu Rahasbistara; Iswahyudi Iswahyudi; I Putu Artha Wijaya
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 10 (2026): Volume 9 Nomor 10 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i10.27629

Abstract

ABSTRACT Purple sweet potato (Ipomoea batatas L.) is a local food that contains anthocyanins and has the potential to be developed as a food source with functional value. However, information about the anthocyanin content of purple sweet potatoes in Bongkasa Pertiwi Village and its comparison with other areas in Bali is not widely known to the public. To increase public knowledge about anthocyanins and bioactive characteristics of purple sweet potatoes through research-based socialization and describing participants' responses to activities. The activity was held on July 18, 2026 in Bongkasa Pertiwi Village, Abiansemal District, Badung Regency, Bali, involving 50 participants. Socialization was carried out through the presentation of materials, presentation of research data, discussions, and questions and answers. Knowledge was measured using a pre-test and post-test which each consisted of 15 questions. The difference in scores was analyzed using a paired t-test at α=0.05, while the characteristics and responses of participants were analyzed descriptively. The average knowledge score increased from 45.2 ± 12.4 to 80.8 ± 9.6, with a difference of 35.6 points (t=18.42; df=49; p0.001). The proportion of participants with very high knowledge categories increased from 0% to 56%, while the low category decreased from 24% to 0%. Based on socialized research data, the anthocyanin content of purple sweet potatoes from Bongkasa Pertiwi was 1.17 ± 0.02 mg/g, higher than Mayungan, Tabanan (0.76 ± 0.01 mg/g) and Ubud, Gianyar (0.11 ± 0.01 mg/g). As many as 92% of participants were active in the discussion, 96% considered the material easy to understand, and 90% were interested in developing purple sweet potatoes as a value-added product. Socialization based on research results was followed by an increase in participants' knowledge and a positive response to the use of purple sweet potato as a local food commodity. Keywords: Anthocyanins, Purple Sweet Potatoes, Local Food, Socialization, Community Knowledge.
Co-Authors A.A Ngurah Subawa Erna Cahyaningsih Handani, Dewa Ayu Sri I Gede Peri Arista I Gusti Ayu Intan Puspita Dewi I Made Jawi I Putu Artha Wijaya I Wayan Putu Sutirta Yasa I Wayan Surya Rahadi Ida Bagus Putra Manuaba Iswahyudi Iswahyudi Komang Januartha Putra Pinatih Made Darmawan Made Rendra Wisnu Rahasbistara Maria Malida Vernandes Sasadara Megawati, Fitria Ni Luh Desy Rupadani Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Putu Ayu Swandewi Astuti Putu Era Sandhi Kusuma Yuda Sasadara, Maria Malida