Article Per Year (5 Year)
p-Index From 2021 - 2026
4.497
P-Index
This Author published in this journals
All Journal International Journal of Biosciences and Biotechnology BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Sains dan Teknologi Indonesian Journal of Medicine JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Midwifery and Nursing Jurnal Riset Kefarmasian Indonesia Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Jurnal Ilmiah Medicamento Jurnal WIDYA LAKSMI (Jurnal Pengabdian Kepada Masyarakat) Usadha Alpatih: Jurnal Inovasi Pengabdian Masyarakat Biosaintifika: Journal of Biology & Biology Education Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Creative Power and Ambition (JCPA)
Maria Malida Vernandes Sasadara
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

Published : 28 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 28 Documents
Search

 1   2   3 
IN VIVO ANTI-INFLAMMATORY ACTIVITY OF DADAP LEAVES (Erythrina subumbrans (Hassk.) Merr) Ni Luh Kade Arman Anita Dewi; Ni Luh Sintya; Maria Malida Vernandes Sasadara; Erna Cahyaningsih; Putu Era Sandhi Kusuma Yuda; Puguh Santoso
International Journal of Biosciences and Biotechnology Vol 9 No 1 (2021): INTERNATIONAL JOURNAL OF BIOSCIENCES AND BIOTECHNOLOGY
Publisher : Central Laboratory for Genetic Resource and Molecular Biology, Faculty of Agriculture, Udayana University in cooperation with Asia-Oceania Bioscience and Biotechnology Consortium (AOBBC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJBB.2021.v09.i01.p03

Abstract

Leguminosae is widely known for its anti-inflammatory properties due to the presence of several beneficial phytochemicals, including alkaloids, flavonoids, steroids, and saponins. Dadap (Erythrina subumbrans (Hassk.) Merr), a Leguminosae member, has empirically been used to treat inflammation. This research aimed to prove the anti-inflammatory effect of Dadap leaves scientifically. Dadap leaves were macerated in 96% ethanol to produced crude ethanol extract, followed by in vivo anti-inflammatory assay with the paw edema method. Three different doses of extract: 200, 300, and 400mg/kg BW, were administrated to Wistar rats to observed its ability in reducing carrageenan-induced inflammatory. All extract doses produced similar anti-inflammatory activity as compared to diclofenac sodium as a positive control. There is no significant difference among the three different doses. The results indicated that all treatment doses produced anti-inflammatory activity, but 200mg/kg BW administration was most efficient.
ANTIOXIDANT ACTIVITY OF THE TOPICAL PREPARATION OF BULUNG SANGU (Gracilaria spp) EXTRACT Maria Malida Vernandes Sasadara; I Gede Putu Wirawan; Made Sritamin; I Ketut Suada; Wayan Adiartayasa
International Journal of Biosciences and Biotechnology Vol 7 No 2 (2020)
Publisher : Central Laboratory for Genetic Resource and Molecular Biology, Faculty of Agriculture, Udayana University in cooperation with Asia-Oceania Bioscience and Biotechnology Consortium (AOBBC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.155 KB) | DOI: 10.24843/IJBB.2020.v07.i02.p04

Abstract

Bulung Sangu (Gracilaria spp) as many other macroalgae, is a source of beneficial phytochemical for health. Phytochemicals in macroalgae are widely used as active ingredients in cosmetic preparations. The study was aimed to determine the antioxidant properties of Bulung Sangu formulated in topical preparation. Bulung Sangu was macerated in ethanol 96% following by extract formulation in cream preparation in two concentrations: 5% and 10%. Antioxidant activity was determined against DPPH radical, compared to ascorbic acid. Percentage of reducing power in five concentration series (10, 20, 30, 40, and 50 µm/ml) statistical analyzes using one-way ANOVA with 95% of confidence level, following by IC50 measurement. Absorbance was read in wavelength of 517 nm. Concentration of 5% and 10% cream extract exhibited IC50 of 13,091 µg/ml and 11,867 µg/ml, respectively. These values are lower than IC50 of ascorbic acid (18,505 µg/ml), indicating the strong antioxidant properties of Bulung Sangu extract cream which is more potential than ascorbic acid. Bulung Sangu exhibit a potential source for being developed as medicine and cosmetics in topical preparation.
Pengaruh Proses Pengolahan Terhadap Kadar Glukosa Dan Serat Total Rumput Laut Bulung Sangu (Gracilaria sp.) Maria Malida Vernandes Sasadara; Ni Ketut Ayu Parwati Pooja; Ni Made Renita Putri
Jurnal Aplikasi dan Inovasi Iptek Vol 4 No 1 (2022): Jurnal Aplikasi dan Inovasi Iptek No. 4 Vol. 1 Oktober, 2022
Publisher : Denpasar Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52232/jasintek.v4i1.92

Abstract

Rumput laut Bulung sangu (Glacilaria sp.) merupakan sumber pangan dengan karbohidrat dan serat yang tinggi. Proses pengolahan bulung sangu dapat mempengaruhi kadar glukosa dan serat yang dikandungnya. Penelitian ini bertujuan untuk mengetahui pengaruh proses perebusan terhadap kadar glukosa dan serat total pada bulung sangu. Penelitian ini merupakan penelitian eksperimental laboratorium. Penetapan kadar glukosa dilakukan dengan metode fenol sedangkan serat total menggunakan metode dari AOAC. Analisis statistika dilakukan menggunakan metode T tidak berpasangan dengan taraf kepercayaan 95%. Hasil penelitian menunjukan kadar glukosa pada 500mg bulung sangu rebus sebesar 226,06 ± 7,42 mg dan bulung sangu segar sebesar 184,44 ± 10,87 mg sedangkan kadar serat total sebesar 83,93 ± 2.31mg pada bulung sangu segar dan 81,1 ± 3.99 mg pada bulung sangu rebus. Hasil analisis statistik menunjukan terdapat perbedaan bermakna pada kadar glukosa (p < 0.05), namun tidak bermakna pada kadar serat total (p>0.05). Dapat disimpulkan bahwa proses perebusan secara signifikan mempengaruhi kadar glukosa, tetapi tidak mempengaruhi kadar serat total secara bermakna pada bulung sangu
Kualitas Minyak Urut Kombinasi VCO dan Cabai Jawa (Piper retrofractum Vahl.) dengan Variasi Suhu Pemanasan pada Proses Digesti Dewa Ayu Ika Pramitha; Ni Wayan Rias Samidya; Luh Dita Sukriani; Maria Malida Vernandes Sasadara; Agung Ari Chandra Wibawa
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.4896

Abstract

The alternative to increasing VCO's functional value is adding spices that contain functional components. In this study, an analysis of the quality of the massage oil preparation of the combination of VCO Piper retrofractum was carried out using heating temperatures of 40°C, 50°C, and 60°C in the digestion process for 8 hours and macerated for 24 hours. The purpose of this study was to determine the best temperature that can be used in the process of making Javanese chili VCO massage oil which has the best quality. The quality parameters determined were water content, acid number, peroxide number, and iodine number. The massage oil is orange and has a distinctive Javanese chili aroma. The results of the analysis of the processed oil produced show that massage oil at 40°C has a water content, acid number, peroxide value, and iodine number of (0.018 ± 0.008) %; (1.185 ± 0.072) mg NaOH/10g; (0.433 ± 0.058) meq/kg; and (7.358 ± 0.032) g iodine/100 g oil. Thus, the best quality is produced by massage oil, which is processed using a temperature of 40°C. It has the lowest water content, acid number, peroxide number, and highest iodine number compared to those obtained at higher heating.
Pengaruh Pemilihan Pelarut dalam Ekstraksi Klorofil pada Rumput Laut Gracilaria sp. dan Caulerpa sp. Segar dan Kering Maria Malida Vernandes Sasadara; Ni Made Dwi Mara Widyani Nayaka; Putu Era Sandhi Kusuma Yuda; Erna Cahyaningsih; Ni Luh Kade Arman Anita Dewi
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.5344

Abstract

Seaweed is a photosynthetic organism, thus a good source of pigment-producing. Pharmaceutical, food, and cosmetic industries widely use chlorophyll pigments for their products. Bulung Sangu (Gracilaria sp.) and Bulung Boni (Caulerpa sp.) are widely grown seaweeds in the waters of Bali. Pre-extraction steps such as drying and solvent selection can affect pigment extraction. This study aimed to evaluate the effect of solvent selection in the extraction of chlorophyll in fresh and dried Bulung Sangu (Gracilaria sp.) and Bulung Boni (Caulerpa sp.). The solvents used were ethanol, methanol, and acetone. Estimation of chlorophyll content was carried out using UV-VIS spectrophotometry. Data were analyzed statistically using one-way ANOVA with a 95% confidence level. The results showed that the extraction of Bulung Sangu (Gracilaria sp.) on dry samples using acetone produced a total chlorophyll of 574.1 ± 33.2 g/g. Bulung Boni (Caulerpa sp.) extraction of fresh samples using methanol resulted in the highest total chlorophyll (10235.3 ± 50.3 g/g). In conclusion, drying and solvent selection affect the extraction of chlorophyll from Bulung Sangu (Gracilaria sp.) and Bulung Boni (Caulerpa sp.).
Literature study: Activity of white turmeric (Curcuma zedoaria) as an anti-inflammatory Ni Nyoman Wahyu Udayani; Ni Nyoman Ayu Puspita Sari; I Made Agus Sunadi Putra; I Putu Tangkas Suwantara; Maria Malida Vernandes Sasadara; Ni Putu Lilis Adnyani
Journal of Midwifery and Nursing Vol. 5 No. 3 (2023): September: Health Science
Publisher : Institute Of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/jmn.v5i3.4092

Abstract

Inflammation is a response given by the body to protect the body against cellular damage, characterized by swelling, redness accompanied by a sensation of heat and pain. Long term use of NSAIDs (Non Steroid Anti Inflammatory Drugs) has side effects such as ulcers, stomach upset, bleeding, nausea, disturbances in the kidneys and the cardiovascular system. White turmeric (Curcuma zedoaria) is a plant that can be used as an anti-inflammatory. This study aims to determine the anti-inflammatory activity of White Turmeric (Curcuma zedoaria) through a literature review in the form of national and international articles or journals. The results of a study of 8 articles that met the inclusion requirements showed that White Turmeric has anti-inflammatory activity. The content of curcumin, essential oils and flavonoids in white turmeric has similarities with NSAIDs, namely by inhibiting the formation of inflammatory mediators.
Kandungan Flavonoid Total dan Aktivitas Antioksidan dari Ekstrak Polaritas yang Berbeda dari Daun Pereskia bleo Nayaka, Ni Made Dwi Mara Widyani; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes; Yuda, Putu Era Sandhi Kusuma; Indriani, Felia Riska
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6290

Abstract

Antioxidant agents are essential for the body due to its ability to scavenge free radicals. Medicinal plants contain phytochemicals that act as antioxidants. The current research aimed to determine the total flavonoid content (TFC) and antioxidant activity of Pereskia bleo leaves extracts from various solvents with different polarities. The nonpolar solvent (n-hexane) was used as the first step of extraction and its residues were then macerated using semi-polar (ethyl acetate) and polar (ethanol 96%) solvents consecutively. The TFC was determined using the colorimetric method while antioxidant activity was examined through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Antioxidant activity was presented as Inhibitory Concentration 50 (IC50) and Antioxidant Activity Index (AAI). It is noticeable that among analyzed extracts, the ethyl acetate extract of P. bleo leaves contained the highest flavonoid content (15.052 ± 0.172 g quercetin equivalent/100 g extract). Furthermore, the greatest antioxidant activity was obtained from n-hexane extract with the value of IC50 and AAI being 217.307 ppm and 0.230, respectively. Pearson coefficient correlation (r) between TFC and AAI was -0.106. The current study concluded that P. bleo leaves extracts using solvents with different polarities showed variation in TFC values and antioxidant activity. Moreover, TFC was not the main contributor to the antioxidant activity of P. bleo leaves extracts.
Uji Aktivitas Antibakteri Ekstrak Etanol Bulung Sangu (Gracilaria Sp.) Terhadap Bakteri Gram Negatif Pseudomonas aeruginosa Putri, Leoni; Vernandes Sasadara, Maria Malida; Cahyaningsih, Erna; Santoso, Puguh
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7262

Abstract

Pseudomonas aeruginosa is a gram-negative bacterium that is pathogenic to humans, especially in causing nosocomial infections. This bacterium has resistance to several classes of antibiotics, one of which is carbapenem and cephalosporin class antibiotics. The development of new antibiotics is an alternative in solving this case. Seaweed is one of the marine biota that has various benefits to be developed due to its primary and secondary metabolite compounds. Secondary metabolites in seaweed are used as a source of bioactive metabolites which have broad antiviral, antifungal and antibacterial activities. Bulung sangu (Gracilaria sp.) is one of the seaweeds that has biological activity as an antibacterial. This study aims to determine the antibacterial effectiveness of 70% ethanol extract of bulung sangu (Gracilaria sp.) on the growth of Pseudomonas aeruginosa bacteria. Sangu bamboo shoots were obtained from the southern Denpasar area (Bali). Bulung sangu viscous extract was extracted using 70% ethanol by ultrasonic method for 5 minutes at 40oC. Phytochemical screening of the extract was carried out to determine the content of secondary metabolite compounds it had. Antibacterial activity testing was carried out using the well diffusion method using 3 extract concentrations namely 4%, 8% and 12%. The positive and negative controls used were chloramphenicol antibiotics and sterile aquadest. Inhibition zones were observed and expressed as mean ± standard deviation (mm). The results were statistically analyzed using Kruskal-Wallis with a 95% confidence level. The inhibition zones generated from the positive control, concentrations of 4%, 8% and 12% could inhibit Pseudomonas aeruginosa bacteria with the following average diameters of the inhibition zones of 25.67mm, 2.00mm, 2.67mm and 2.67mm in the weak inhibition zone category.
Mini Review: Potensi Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp) sebagai Antibakteri Yuda, Putu Era Sandhi Kusuma; Pramesti , Luh Ratih Widhia; Widyani Nayaka , Ni Made Dwi Mara; Anita Dewi, Ni Luh Kade Arman; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7036

Abstract

  Infectious diseases by bacteria are one of the problems in the world of health. The therapy that can be given to people with bacterial infections is antibiotics. However, the increasing incidence of antibiotic resistance and bacterial infections requires other antibiotic alternatives such as those sourced from natural materials. Bay leaf (Syzygium polyanthum (Wight) Walp) included in the Myrtaceae family is one of the plants that is widely known among Indonesian people which empirically has properties in curing various diseases. Bay leaves are known to contain secondary metabolite compounds such as flavonoids, tannins, alkaloids, saponins, triterpenoids, steroids, eugenol, and essential oils that function as antibacterials. This literature review aims to discuss the antibacterial activity of bay leaves against gram-positive and gram-negative bacteria as well as the components of active compounds in bay leaves and their mechanism as antibacterials. The method used in the preparation of this review article is the literature study method. This research uses secondary data taken from the results of other researchers' research in the form of scientific articles that have been published in national and international scientific journals with a year limit from 2014 to 2023. Based on the literature study that has been done, it is known that bay leaves have potential as antibacterials against both gram-positive and gram-negative bacteria. The antibacterial activity is known to be related to the content of active compounds such as flavonoids, tannins, alkaloids, saponins, triterpenoids, steroids, phenols, and essential oils.
Kajian Etnofarmasi Kelompok Masyarakat Banjar Subamia Kelong, Tabanan Bali Perayanthi, Reni; Anita Dewi, Ni Luh Kade Arman; Kusuma Yuda, Putu Era Sandhi; Cahyaningsih, Erna; Vernandes Sasadara, Maria Malida; Suradnyana, I Gede Made; Sugiyanto, Milyadi
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7369

Abstract

  Bali is rich in culture and traditions passed down from generation to generation, especially in the ethnopharmacy aspect as a traditional medecine. This research aims to study ethnopharmacy aspects of the application of herbal plants as traditional medicine including plant parts, processing methods, indications, and usage of herbal plants in Banjar Subamia Kelong, Tabanan, Bali. This research was carried out using survey methods, direct observation in the field, and interviews. This research identified 20 types of plants that are generally used by the community in the Banjar Subamia Kelong. The plant parts generally used are leaves (60%), stems (15%), rhizomes (15%) and fruit (10%). Most of the plants are processed by boiling (60%). These medicinal plants are mostly used orally (65%), and the general indication is to treat joint problems, such as muscle pain and gout (25%).
Co-Authors Ade Irma Suryani Ade Irma Suryani Adinda Puspita Elisabet Lian Agung Ari Chandra Wibawa Anak Agung Sagung Intan Gayatri Anak Agung Vivi Noviyanti Anita Dewi, Ni Luh Kade Arman Apriliani, Ni Luh Putri Buana, Komang Dirga Mega Budayasa, I Putu Gede Candraningrat, I Dewa Agung Ayu Diva Darmawan, I Wayan Agus Debby Juliadi Desak Ketut Ernawati Dewa Ayu Arintini Kusuma Dewa Ayu Ika Pramitha Dewi Ani Anjani Dewi, Ni Kadek Dwi Purnama Dwi Arymbhi Sanjaya Erna Cahyaningsih Gede Agus Ari Tirtayasa Gusti Ketut Asti Dea Ningsih Handani, Dewa Ayu Sri I Dewa Agung Ayu Diva Candraningrat I Dewa Gede Agung Pandawana I Dewa Made Adi Baskara Joni I Gede Putu Wirawan I GEDE PUTU WIRAWAN I Gusti Ayu Sri Candramukhi Devi Dasi I Ketut Suada I Made Oka Parwata I Nyoman Wijaya I Putu Tangkas Suwantara I Wayan Mahardika Saputra Indriani, Felia Riska Intan Alfira Kolifay Kusuwa Wardani, I Gusti Agung Ayu Lambok Jenny Sagita Munthe Luh Dita Sukriani Luh Putri Dianti Laksmi MADE SRITAMIN Mahardika, I Made Agus Megawati, Fitria Mendra, Ni Nyoman Yudianti Ni Kadek Jessica Agustin Ni Kadek Lita Ni Ketut Ayu Parwati Pooja Ni Luh Gede Erica Fridayana Ni Luh Gede Wiwin Pebriani Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Sintya Ni Made Dwi Mara Widyani Nayaka Ni Made Renita Putri Ni Nyoman Ayu Puspita Sari Ni Nyoman Ita Trisnadewi Ni Nyoman Wahyu Udayani Ni Nyoman Zelina Aswindari Ni Putu Arie Leony Kertita Ni Putu Jayanti Putri Ni Putu Lilis Adnyani Ni Wayan Rias Samidya Partama, I GD. Yudha Perayanthi, Reni Pramesti , Luh Ratih Widhia Prawitasari, Putu Putri Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Putri, Leoni Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Putu Era Sandhi Kusuma Yuda Suarnata, I Gede Agus Sugiyanto, Milyadi Suradnyana, I Gede Made Wardani, I Gusti Agung Ayu Kusuma WAYAN ADIARTAYASA Widyani Nayaka , Ni Made Dwi Mara Wiranata, I Gede Wulaningtyas, Ni Ketut Maha Yanti, Ni Kadek Pradnya Yundari, Yundari