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Optimization and Validation of Clobazam Content Determination Method in Tablet Preparations Using High Performance Liquid Chromatography (HPLC) Agustina, Rosita; Mulyadi, Dikdik; Yuningsih, Lela Mukmilah
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9837

Abstract

Clobazam is a tablet-shaped drug whose concentration was analyzed using the HPLC separation method. Analysis of clobazam concentration using a method in accordance with FI VI, with a mobile phase composition of 70 mL of water and 30 mL of acetonitrile, resulting in a retention time of 21 minutes. The purpose of this study was to obtain the most optimal composition of the mobile phase and column to obtain a faster retention time in the analysis of clobazam levels. As well as to validate the analysis method whose results are in accordance with the validation requirements in the Indonesian pharmacopoeia VI. Data were analyzed using linearity tests, specificity or selectivity tests, accuracy tests, repeatability and intermediate precision tests, robustness tests, and LOS and LOQ tests. The results showed a theoretical plate number of 1711.5, a tailing factor of 1.34, and a retention time of 1.69 minutes using a C18 column measuring 150 x 3 mm 3 μm with a mobile phase ratio of acetonitrile: water of 80:20. The validation results of the analytical method for accuracy, precision, selectivity, and robustness showed RSD <2%, Detection Limit (LOD) 0.0014 mg/mL, Quantification Limit (LOQ) 0.0042 mg/mL, and the linearity test results showed a correlation coefficient of 0.999, meeting the FI VI validation criteria. The conclusion is that differences in the composition of the mobile phase and the particle size of the column greatly affect the characteristics of the chromatogram produced in HPLC analysis.
Analisis Makna Tanda Ikon, Indeks, dan Simbol Semiotika Charles Sanders Peirce pada Film 2014 Siapa di Atas Presiden? Oktaviani, Ursula Dwi; Susanti, Yudita; Tyas, Debora Korining; Olang, Yusuf; Agustina, Rosita
Stilistika: Jurnal Pendidikan Bahasa dan Sastra Vol 15 No 2 (2022)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/st.v15i2.13017

Abstract

Icon Signed Meaning Analysis, Indexs and Semiotics Symbol in Charles Sanders Peirce in 2014 Siapa di Atas Presiden? Movie ABSTRAKFilm 2014 Siapa di Atas Presiden? bertemakan konflik politik dengan mengangkat latar belakang pemilihan presiden pada tahun 2014 periode 2014-2019. Film ini memberikan gambaran tentang dunia politik. Penelitian ini mengkaji tentang analisis semiotika pada Film 2014 Siapa di Atas Presiden?.  Tujuan dari penelitian ini mendeskripsikan makna tanda dalam film 2014 Siapa di Atas Presiden?, untuk menunjukkan tanda ikon, tanda indeks dan tanda simbol, serta mendeskripsikan makna dari tanda ikon, tanda indeks dan tanda simbol dalam film 2014 Siapa di Atas Presiden?. Penelitian ini menggunakan pendekatan   kualitatif, metode   deskriptif, teknik   pengumpulan   data melalui baca catat dan teknik dokumentasi. Temuan yang diperoleh yaitu: 1) Ikon yang menunjukan adanya hubungan persamaan  antara tanda dengan objek manusia (tokoh dalam novel) dan benda 2) Indeks adalah tanda yang menunjukan hubungan tanda dengan objek bersifat diperkirakan, atau hubungannya menunjukkan sifat hubungan kasual (sebab-akibat), arbitrer dan diperkirakan 3) Makna tanda ikon berdasarkan hubungan tanda dengan objek pada tipe ikon maka hubungan tanda dan objek dalam gambar  yaitu  sama  antara gambar dan tanda ikon.Kata kunci: Semiotika; Film 2014 Siapa di Atas Presiden?ABSTRACT2014 siapa di atas presiden? movie has political conflict theme by taking the background of the 2014 presidential election in 2014-2019 period. This movie provides an overview of the politics world. This study examines the semiotic analysis in the 2014 siapa di atas presiden? movie. The purpose of this study is to describe the meaning of the sign in the 2014 siapa di atas presiden? movie, in order to show icon sign, index sign and symbols, and also to describe the meaning of icon sign, index sign and symbols in the 2014 siapa di atas presiden? movie. This research used a qualitative descriptive method, data collection techniques were through reading notes and technical documentation.  Based  on  research  results as follows: 1) Icons that show a similar relationship between signs and human objects (characters in novels and objects, 2) Index is a sign that revealed the relationship between signs and objects is predictable or the relationship shows the nature of casual (cause and effect), arbitrary and predictable relationships, 3) Icon sign meaning is based on sign and object relationship in icon type. It is therefore the relationship of sign and object in image is similar to image and icon sign.Keyword: Semiotics, Movie 2014 Siapa di Atas Presiden