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All Journal Inovasi Kesehatan Global Borneo Community Development
Abu Dzar Alghifary
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Kajian Stabilitas Fisikokimia Antibiotik β-laktam: Implikasi terhadap Formulasi dan Penyimpanan Abu Dzar Alghifary; Nor Latifah
Inovasi Kesehatan Global Vol. 2 No. 3 (2025): Agustus : Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v2i3.2215

Abstract

β-lactam antibiotics are a very important group of drugs and are most frequently used in the treatment of bacterial infections, both in healthcare facilities and for self-medication. The advantages of β-lactams lie in their effectiveness and broad spectrum of action. However, the development of pharmaceutical preparations containing β-lactams still faces significant challenges, particularly related to the physicochemical stability of these compounds. The reactive ring structure of β-lactams makes them highly susceptible to degradation, particularly through hydrolysis. This degradation process can be accelerated by various environmental factors such as high temperature, changes in pH, humidity, and the presence of certain excipients and solvents in drug formulations. This article comprehensively reviews the various factors that influence the stability of β-lactams, both in solid and liquid pharmaceutical dosage forms, as well as in microbiological media. Furthermore, it also examines various innovative formulation approaches that have been developed to improve the stability of these compounds. These approaches include film coating technology, encapsulation, and crystal engineering, which have been shown to reduce the rate of degradation and extend product shelf life. Literature studies have shown that solid dosage forms are generally more stable than liquid dosage forms, primarily because exposure to water and solvents can accelerate hydrolysis. Distribution and storage of these preparations are also important aspects to consider in maintaining the quality and effectiveness of β-lactam antibiotic therapy. Therefore, β-lactam product development requires a holistic approach, encompassing not only formulation and production technology but also optimal distribution and storage strategies. The use of appropriate analytical methods is also necessary to monitor degradation products and ensure product safety and effectiveness throughout the shelf life.
Program Sapa Sehat ke Rumah: Strategi Pemeriksaan Kesehatan Door to Door untuk Deteksi Dini Hipertensi dan Diabetes pada Lansia Herda Ariyani; Abu Dzar Alghifary; Anisa Diva Ramadhani; Dhiya Shoufi Sahaja; Gina Aqifah; Muhammad Haikal Rifqy; Muhammad Romansyah Khatami; Nailia Nur Isma Sumarno; Noor Kamalliyah Kamalliyah; Prilia Candra Noorazmi; Risma Yulidah Yulidah; Sri Rezeki Solehah; Susan; Tri Indah Lestari; Zalmiati
Borneo Community Development Vol. 6 No. 1 (2026)
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/bcd.v6i1.1510

Abstract

Non-communicable diseases (NCDs) such as hypertension, diabetes mellitus, hypercholesterolemia, and hyperuricemia remain major health problems in Indonesia, especially among the elderly. In Balangan Regency, South Kalimantan, hypertension has been reported as the most common NCD among elderly patients in the Lampihong Health Center area, while limited healthcare access in rural villages such as Matang Hanau further increases the risk of late detection and complications. To address this urgent issue, the Community Service Program (KKN) in Matang Hanau Village, Lampihong District, was implemented through a door-to-door health screening strategy aimed at early identification of NCD risk factors. The program involved coordination with village officials, collaboration with Lampihong Health Center and Matang Hanau Sub-Health Center (Pustu), provision of health education, blood pressure and blood sugar checks, and distribution of educational leaflets combined with direct consultation. A total of 258 residents participated, with most elderly showing above-normal blood pressure and blood sugar levels. The program successfully increased community awareness and willingness to undergo routine health checks, highlighting the urgency of strengthening community-based screening as a sustainable approach to reducing the burden of NCDs in Balangan Regency.
Co-Authors Anisa Diva Ramadhani Dhiya Shoufi Sahaja Gina Aqifah Herda Ariyani Muhammad Haikal Rifqy Muhammad Romansyah Khatami Nailia Nur Isma Sumarno Noor Kamalliyah Kamalliyah Nor Latifah Prilia Candra Noorazmi Risma Yulidah Yulidah Sri Rezeki Solehah Susan Tri Indah Lestari Zalmiati