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All Journal Nusantara Hasana Journal Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Muhammad Khudzaifi
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Nursing Public Health

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UJI RHODAMIN B PADA LIP CREAM YANG BEREDAR DI TOKO KOSMETIK KOTA KUDUS MENGGUNAKAN KROMATOGRAFI LAPIS TIPIS Safira Ramandani; Endang Setyowati; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1515

Abstract

Cosmetic products, including lipstick, are products that require coloring agents, usually in the form of lip cream preparations. One of the dangerous coloring agents circulating in the market is Rhodamine B. Rhodamine B is a dangerous synthetic dye that is carcinogenic. The purpose of this study was to identify the presence of Rhodamine B in lip creams circulating in Kudus City. The research method was carried out quantitatively because it determined the levels of Rhodamine B using Thin Layer Chromatography (TLC). The lip cream samples studied were 5 samples with different brands and sold at the Kudus City Cosmetics Store. Rhodamine B identification test on lip cream by observing the number of Retention Factor (Rf) values, visual stain color, and fluorescence color under UV light 254 nm and 366 nm. The identification results of the five samples tested contained two samples suspected of containing synthetic rhodamine B dye, namely samples A and E, this can be seen from the color of the spots seen visually are pink and orange, while under UV light it is purple and fluoresces yellow. For the Rf value of rhodamine B of 0.68, it is the same as sample A, while samples B, C, D, and E have a value of 0.7. The conclusion of this study is that the five lip cream samples with different brands contain Rhodamine B, namely in sample A and E.
FORMULASI UJI AKTIVITAS ANTIOKSIDAN DAN UJI KARAKTERITIK FISIK SEDIAAN KRIM EKSTRAK DAUN PEPAYA (Carica Papaya L.) SEBAGAI KRIM PELEMBAB KULIT Muhammad Lathoiful Minan; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1546

Abstract

Papaya leaves are known to contain high levels of antioxidants such as flavonoids, α- tocopherol, and ascorbic acid, which help combat free radicals that cause premature aging. This study aimed to evaluate the stability and antioxidant activity of a cream formulated with 70% ethanol extract of papaya leaves using the DPPH method. A total of 3000 g of young papaya leaves were macerated with 70% ethanol, yielding 56.38 g of thick extract, which was then formulated into a cream. The cream was evaluated through organoleptic tests, homogeneity, pH, spreadability, emulsion type, viscosity, and antioxidant activity. Results showed the cream was stable in terms of odor and form, with a pH range of 5–7, spreadability between 5.8–6.2 cm, homogeneous emulsion, and viscosity ranging from 5003–5990 cP. The highest antioxidant activity was observed at 3.5% concentration (78.45%), while the negative control was 222.4 and quercetin as a reference showed 9.08%. It was concluded that the cream formulated from 70% ethanol extract of papaya leaves demonstrated good stability and strong antioxidant activity.
FORMULASI DAN UJI FISIK SEDIAAN KRIM KOMBINASI MINYAK BIJI JINTEN HITAM (Nigella Sativa L.) DAN EKSTRAK DAUN PEPAYA (Papaya Carica L.) SEBAGAI TABIR SURYA Akbar Seno Syafriansyah; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1547

Abstract

Prolonged exposure to sunlight can have harmful effects on the skin, both immediate and long-term. To prevent the negative impact of sun exposure, the use of additional protective products such as sunscreen is essential. To reduce the level of damage caused by the use of synthetic materials, the use of natural ingredients can be considered as components in the formulation of sunscreen creams. This study aims to evaluate the physical quality and determine the sunscreen activity of a cream formulation combining black cumin seed oil (Nigella sativa L.) and papaya leaf extract (Carica papaya L.). The evaluation was conducted through several tests, including organoleptic testing, homogeneity, emulsion type, pH, viscosity, and SPF testing using UV-Vis spectrophotometry. The results showed that the formulation met the required standards: organoleptic tests indicated that the scent and texture of the cream remained stable, although a change in color occurred. The formulation had good homogeneity with a pH ranging from 5 to 7. The recorded viscosities were 9732 cP, 1450 cP, 3030 cP, and 4414 cP, respectively. In the SPF test, the values obtained were 0.22; 4.37; 14.23; and 20.52. Based on these results, it can be concluded that the cream combining black cumin seed oil and papaya leaf extract demonstrated good stability and exhibited effective sunscreen activity.
HUBUNGAN PEMBERIAN EDUKASI SWAMEDIKASI OBAT ANTINYERI DENGAN KEPUASAN PASIEN DI APOTEK BLUNYAH FARMA Vita Angraini; Ria Etikasari; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1617

Abstract

Self-medication, particularly for pain, is becoming increasingly common. However, most patients still lack adequate understanding of the types of medications, dosages, and potential risks. Therefore, education provided by pharmacists plays a crucial role in improving patient understanding and satisfaction with the rational use of painkillers. This study aimed to determine the relationship between self-medication education on painkillers and patient satisfaction at Blunyah Farma Pharmacy, Sleman Regency, Yogyakarta. The study used a quantitative observational method with a cross-sectional design. The independent variable was self-medication education on painkillers, while the dependent variable was patient satisfaction. Data were collected through questionnaires completed directly by patients purchasing painkillers. The study sample consisted of 300 respondents from a total population of 1,200, with a margin of error of 5%. The results showed that the majority of respondents received high levels of education (57.7%) and expressed very high levels of satisfaction with the services they received (40.3%). A Spearman Rank correlation test using SPSS version 22 showed a very strong and significant relationship between the two variables, with a correlation coefficient of 0.941 and a significance level of 0.000 (<0.05). Therefore, the better the quality of education provided, the higher the patient satisfaction level.
Pengaruh Antibakteri Kombinasi Ekstrak Kulit Jeruk Manis (Citrus Sinensis (L.) Osbeck) dan Daun Pepaya (Carica Papaya L.) Terhadap Bakteri Escherichia Coli Regitha Adiba Fayza Purwoko; Riana Putri Rahmawati; Muhammad Khudzaifi
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6079

Abstract

Sweet orange peel and papaya leaves have been used by the community to prevent and treat various diseases caused by bacterial, fungal, and viral infections. Sweet orange peel contains flavonoids, alkaloids, saponins, tannins, and terpenoids that can inhibit bacterial growth. While papaya leaves contain active compounds such as alkaloids, flavonoids, steroids, tannins, and terpenoids that can inhibit bacterial growth. Escherichia coli bacteria are gram-negative, facultative anaerobic bacteria that can cause intestinal infections, causing diarrhea. The combination of extracts from several plants has greater inhibitory power so that it has greater antibacterial activity than a single plant. The purpose of this study was to determine whether the combination of sweet orange peel and papaya leaf extracts has an effect on the growth of Escherichia coli bacteria. The test method used was the disc diffusion method on TSA agar media. Sweet orange peel and papaya leaf extracts in this study were obtained by the maceration method with 96% ethanol solvent. The ratio of extracts used was sweet orange peel and papaya leaves 1:3; 2:2; 3:1. The positive control used was ciprofloxacin. The negative control used was 10% dimethyl sulfoxide (DMSO). The results of this study indicate that the combination of sweet orange peel extract (Citrus sinensis L. Osbeck) and papaya leaves (Carica papaya L.) has an effect on the growth of Escherichia coli bacteria because it produces an inhibition zone around the disc paper. All comparisons, namely 1: 3; 2: 2; 3: 1 are optimal in inhibiting the growth of Escherichia coli bacteria with a diameter of the inhibition zone in sequence of 17.78 mm (strong category), 22.14 mm (very strong category), and 26.28 mm (very strong category). Likewise, the positive control produces an inhibition zone of 34.25 (very strong category). The most optimum antibacterial combination shows the diameter of the inhibition zone against Escherichia coli bacteria, namely at a ratio of 3: 1.
Co-Authors Akbar Seno Syafriansyah Endang Setyowati Muhammad Lathoiful Minan Muhammad Nurul Fadel Regitha Adiba Fayza Purwoko Ria Etikasari Riana Putri Rahmawati Safira Ramandani Vita Angraini