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All Journal Jurnal Biologi Tropis
Dhevi, Ni Made Saithanya Gitanjali
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Literature Study: Acute Myeloid Leukimia (AML) Pramesti, Evane Dyahayu; Dhevi, Ni Made Saithanya Gitanjali; Hudhori, Syalsa; Salsabila, Ericha Zabrina; Asriantin, Isna; Anggoro, Joko
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10082

Abstract

Leukemia is a cancer that originates from cells that initially develop into blood cells. Leukemia can be classified as acute or chronic, depending on how quickly the disease appears and how it progresses in the body. This literature review aims to determine the treatment for patients with AML depending on the subtype. This literature review used journal review methods and data searches through various sources. The results of the literature study found that Acute Myeloid Leukemia (AML) is divided into six subtypes. AML is caused by clonal transformation of hematopoietic cells through chromosomal abnormalities and gene mutations, with risk factors including exposure to radiation, benzene, smoking, chemotherapy therapy, the development of chronic myeloid neoplasms, aging, and predisposing diseases. Diagnosis of AML involves peripheral blood and bone marrow analysis, immunophenotyping, cytogenetics, molecular cytogenetics, and imaging to detect the presence and characteristics of leukemic cells. Treatment of AML includes induction therapy, consolidation therapy, and response monitoring, with special considerations for the selection of chemotherapy regimens, stem cell transplantation, and transfusion support to manage associated complications. In conclusion, Acute Myeloid Leukemia (AML) is a condition in which myeloblasts undergo excessive proliferation and fail to differentiate into granulocytes. This condition causes the bone marrow to fill with myeloblasts.
Management of Respiratory Emergencies and Acute Respiratory Distress Syndrome (ARDS) in Emerging Infectious Diseases: A Literature Review on COVID-19 Dhevi, Ni Made Saithanya Gitanjali; Setiasari, Febi Jian; Asriantin, Isna; Nitzana, Lale Nubya; Aghni, Hasna Tazkia
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10990

Abstract

Emerging infectious diseases, including SARS-CoV-2, have become major global health challenges with significant clinical and social impacts. One of the most frequent and fatal complications of COVID-19 is Acute Respiratory Distress Syndrome (ARDS), characterized by impaired gas exchange due to diffuse lung injury. This study is a narrative review analyzing 28 articles on the epidemiology, pathophysiology, clinical features, and management of COVID-19 related ARDS (CARDS). The findings show that CARDS presents with greater severity and higher mortality than ARDS caused by other etiologies, driven by excessive inflammatory responses, endothelial dysfunction, and microthrombosis. Clinical manifestations progress from early COVID-19 symptoms to worsening hypoxemia in accordance with the Berlin criteria. Emergency management of COVID-19 with ARDS emphasizes the ABCDE approach, stabilization of respiratory and circulatory functions, and indication-based interventions to prevent respiratory failure and improve oxygenation. This review is expected to serve as a comprehensive reference for healthcare professionals in understanding and optimizing the management of CARDS.
Co-Authors Aghni, Hasna Tazkia Anggoro, Joko Asriantin, Isna Hudhori, Syalsa Nitzana, Lale Nubya Pramesti, Evane Dyahayu Salsabila, Ericha Zabrina Setiasari, Febi Jian