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All Journal Medical and Health Science Journal Community Development Journal: Jurnal Pengabdian Masyarakat International Islamic Medical Journal Prominentia Medical Journal
Jazuli, Muhammad Aqil Siroj
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Religion Humanities Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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The Role Of Mitragyna speciosa (Korth) As An Anti-Inflammatory Agent In Wound Healing In Living Cells Ferdinan Hanafi, Eka Satria Akbar; Pramesti, Rosandhy Alfiyah; Jazuli, Muhammad Aqil Siroj; Rihhadatulays, Khuzaimah Nur Juhanifah; Salim, Hotimah Masdan; Savitri, Ardyarini Dyah
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 1 (2025): FEBRUARY : Fragmentation In Modern Healthcare Approaches Amid Rising Chronic And
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i1.7994

Abstract

Background: Wound is a condition in which the integrity of body tissue is disrupted, leading to the activation of a complex biological process known as wound healing. This process aims to restore the protective skin barrier, prevent infection, and minimize fluid loss. It involves sequential phases of hemostasis, inflammation, proliferation, and remodeling. While inflammation is essential for initiating repair, prolonged or excessive inflammation may delay the healing process. Mitragyna speciosa (Korth) is a medicinal plant traditionally used in various cultures and has been reported to exhibit multiple pharmacological properties, including anti-inflammatory, antioxidant, antibacterial, analgesic, and wound-healing activities. Methods: The present systematic review was conducted to identify and synthesize scientific evidence regarding the potential of Mitragyna speciosa extract as a therapeutic agent in wound healing through anti-inflammatory and other biological pathways. Literature searches were performed in ScienceDirect, PubMed, MDPI, DOAJ, and Google Scholar following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results :A total of 1,176 studies were screened, and five experimental studies fulfilled the inclusion criteria. The findings consistently demonstrated that Mitragyna speciosa extract suppressed pro-inflammatory mediators such as nitric oxide, reactive oxygen species, tumor necrosis factor-alpha, interleukin-6, and enzymatic pathways including cyclooxygenase-2 and 5-lipoxygenase. In addition, the extract stimulated cell migration, endothelial migration, and angiogenesis, thereby supporting tissue regeneration. Toxicity profiles suggest that the extract is safe at effective concentrations, although responses remain dose-dependent. Conclusions: Overall, Mitragyna speciosa shows promise as a plant-based therapeutic option for wound healing. Nevertheless, current evidence is limited and largely derived from in vitro studies, indicating the need for more extensive in vivo and clinical investigations.
PELATIHAN PEMBUATAN MINUMAN HERBAL PADA KADER SIAGA KUSTA DUSUN SUMBERGLAGAH KAB. MOJOKERTO Handayani, Handayani; Bastiana, Bastiana; Winarningsih, Wiwik; Munir, Ratna Sofaria; Puspitasari, Renny Novi; Febriyanti, Aisyah Fatin; Jazuli, Muhammad Aqil Siroj; Rahmatullah, Falih Dhiya'ulhaq; Fardian, Ghalief Fernanda Putra; Salsabillah, Adityas Sabrina; Ekayanti, Retno Diah Putri
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 5 (2024): Vol. 5 No. 5 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i5.36947

Abstract

penderita kusta agar lebih mudah menjangkau pengobatan di RSUD Sumber Glagah. Hingga saat ini di Dusun Sumberglagah masih terdapat 300 orang penderita orang kusta namun sebagian besar sudah sembuh dan masih ada 20 orang yang sedang dalam pengobatan dibawah pengawasan RSUD Sumberglagah Pacet Mojokerto. Salah satu upaya untuk mencegah terjadinya penularan penyakit kusta ialah dengan rutin mengkonsumsi makan-makanan bergizi serta menerapkan perilaku hidup bersih dan sehat. Disamping itu juga dapat disertai mengkonsumsi minuman herbal secara rutin mampu membantu menjaga kesehatan serta meningkatkan imunitas tubuh. Namun karena kurangnya pengetahuan dari Kader Siaga Kusta akan manfaat dari minuman herbal sehingga masyarakat di Dusun Sumberglagah perlu mendapatkan sosialisasi untuk meningkatkan pengetahuan dan keterampilan kader siaga kusta tentang pembuatan minuman herbal Jahe, Kunyit, Daun Salam, dan Secang. Metode yang digunakan dalam kegiatan ini ialah penyuluhan dan pelatihan. Hasil dari penyuluhan dan pelatihan didapatkan peningkatan pengetahuan sebesar 83,34%. Diharapkan para kader siaga kusta mampu menerapkan ilmu dan keterampilan yang telah diajarkan agar bisa diaplikasikan ke kegiatan sehari-hari, serta mampu meneruskan pengetahuan dan keterampilan nya kepada masyarakat luas khususnya warga Dusun Sumberglagah
EDUKASI KESEHATAN TENTANG GAWAT DARURAT ABDOMEN DI INTERNATIONAL ORGANIZATION OF IMMIGRATION SIDOARJO Bhayusakti, Aditya; Wibawa, Dayu Satriya; Shafly, Moch Syafirul Nur; Jazuli, Muhammad Aqil Siroj
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 6 (2024): Vol. 5 No. 6 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i6.37605

Abstract

Gawat darurat abdomen atau nyeri akut abdomen adalah suatu kasus kegawatdaruratan abdomen yang dapat terjadi karena masalah bedah dan non bedah, ditandai dengan keluhan nyeri abdomen yang terjadi secara tiba-tiba dan berlangsung kurang dari 24 jam. Pemahaman yang kuat tentang anatomi dasar dan fisiologi saluran pencernaan diperlukan untuk diagnosis dini yang akurat. Hal ini dapat terlihat saat menilai riwayat pasien dan, khususnya, saat melakukan pemeriksaan fisik pada perut. siapa saja. Tujuan pengabdian kepada masyarakat ini adalah untuk memberikan Pelatihan Kader Kesehatan Pengungsi tentang Gawat Darurat Abdomen di International Organization for Migration (IOM) Sidoarjo. Kegiatan pengabdian kepada masyarakat ini ditujukan kepada imigran IOM Sidoarjo. Acara dilaksanakan pada hari Kamis, 29 Agustus 2024 di halaman kampus B Tower Universitas Nahdlatul Ulama Surabaya. Kegiatan ini dilaksanakan dengan metode presentasi mengenai tanda gawat darurat abdomen. Kegiatan pengabdian kepada masyarakat ini telah terlaksana pada tanggal pelaksanaan pada hari Kamis tanggal 29 Agustus 2024. Acara dilaksanakan di halaman parkir kampus B Tower Universitas Nahdlatul Ulama Surabaya. Evaluasi penulis mengenai kegiatan ini adalah peserta dapat menjawab tiga pertanyaan dari pemateri dengan benar, diantaranya adalah anatomi perut, tanda dan gejala gawat darurat abdomen, dan apa yang harus dilakukan jika ada orang disekitar yang mengalami keluhan tersebut. Materi mengenai kegawatdaruratan abdomen telah tersampaikan dengan baik kepada peserta. Peserta antusias dan aktif bertanya kepada pemateri seputar gawat darurat abdomen. Harapan penulis agar peserta mengetahui mengenai gawat darurat abdomen, sehingga jika terjadi pada orang sekitarnya mereka dapat memberi masukan agar segera dibawa ke fasilitas kesehatan segera guna mengatasi kondisi gawat daruratnya.
Effect of Kratom (Mitragyna speciosa) Hydrogel on Liver Function in Diabetic Burn Injury Pramesti, Rosandhy Alifyah Pramesti; Jazuli, Muhammad Aqil Siroj; Ismail, Zainul Hadi Wildan; Rihhadatulays, Khuzaimah Nur Juhanifah; Hanafi, Eka Satria Akbar Ferdinan; Jinan, Puspita Rahmatul; Salim, Hotimah Masdan; Bermawi, Bastiana
Jurnal Medis Islam Internasional Vol 7 No 2 (2025): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v7i2.8239

Abstract

Introduction: Burns are serious injuries that not only damage the skin but can also affect internal organs such as the liver. Severe inflammation following burn injury increases hepatocyte vulnerability, especially in diabetic conditions. Objective: This study aimed to evaluate the effect of topical kratom (Mitragyna speciosa) hydrogel on liver histopathology in streptozotocin-induced diabetic mice with burn injuries. Methods: An in vivo experimental study with a post-test-only control group design was conducted using 15 male musmusculus. Diabetes mellitus was induced prior to burn injury, and hyperglycemia was confirmed before further procedures. The diabetic mice were then randomly assigned into three groups: diabetic burn injury without hydrogel treatment (K), diabetic burn injury treated with 5% kratom hydrogel (T1), and diabetic burn injury treated with 15% kratom hydrogel (T2). The respective treatments were applied for four weeks. Following the intervention period, liver tissues were collected for histopathological analysis. Hepatocyte damage was quantitatively assessed and analyzed using one-way ANOVA followed by Dunnett’s post hoc test. Results: The diabetic burn injury control group exhibited the greatest extent of hepatocyte damage (66.5 ± 5.0%). Application of 5% kratom hydrogel (49.5 ± 4.0%) and 15% kratom hydrogel (52.5 ± 4.0%) resulted in a statistically significant reduction in hepatocyte injury compared with the diabetic control group (p = 0.0043 and p = 0.0131, respectively). Conclusions: Topical administration of kratom hydrogel significantly attenuated hepatocyte damage in diabetic mice subjected to burn injuries, suggesting a hepatoprotective effect and potential benefits for preserving liver function under diabetic burn conditions.
Efektivitas Penggunaan Hidrogel Kratom Terhadap Kadar Gula Darah Pada Ulkus Diabetikum Rihhadatulays, Khuzaimah Nur Juhanifah; Pramesti, Rosandhy Alifyah; Hanafi, Eka Satria Akbar Ferdinan; Jazuli, Muhammad Aqil Siroj; Salim, Hotimah Masdan; Amani, Fariska Zata; Aisyah, Aisyah
Bahasa Indonesia Vol 6 No 2 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i2.6076

Abstract

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. One of the most common complications is diabetic ulcers, which are often associated with vascular impairment, infection, and poor glucose stability. The search for alternative therapies continues to develop, including the use of Mitragyna speciosa (kratom) leaves, which contain mitragynine and flavonoids that have been shown to inhibit α-glucosidase and enhance antioxidant activity. This study aimed to evaluate the effect of kratom hydrogel on blood glucose levels in an animal model of diabetic ulcers. Using a posttest-only control group design, mice (Mus musculus) were induced with streptozotocin to establish a type 2 diabetes model. The animals were divided into three groups: positive control, 5% kratom hydrogel, and 15% kratom hydrogel. Blood glucose levels were measured weekly over a two-week period. Data were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison test. The results showed differences in blood glucose levels among all treatment groups. The 15% kratom hydrogel group demonstrated a significant reduction in blood glucose, approaching near-normal levels compared with the positive control (p < 0.05). Statistical analysis indicated a more dominant effect compared to the variation of treatment types. These findings suggest a synergistic mechanism through α-glucosidase inhibition and enhanced antioxidant activity. Therefore, kratom hydrogel has potential as a complementary therapy for glycemic control in patients with type 2 diabetes mellitus complicated by diabetic ulcers.
Co-Authors Aisyah Aisyah Bastiana Bastiana Bermawi, Bastiana Bhayusakti, Aditya Ekayanti, Retno Diah Putri Fardian, Ghalief Fernanda Putra Fariska Zata Amani Febriyanti, Aisyah Fatin Ferdinan Hanafi, Eka Satria Akbar Hanafi, Eka Satria Akbar Ferdinan Handayani Handayani Ismail, Zainul Hadi Wildan Jinan, Puspita Rahmatul Pramesti, Rosandhy Alfiyah Pramesti, Rosandhy Alifyah Pramesti, Rosandhy Alifyah Pramesti Puspitasari, Renny Novi Rahmatullah, Falih Dhiya'ulhaq Ratna Sofaria Munir, Ratna Sofaria Rihhadatulays, Khuzaimah Nur Juhanifah Salim, Hotimah Masdan Salsabillah, Adityas Sabrina Savitri, Ardyarini Dyah Shafly, Moch Syafirul Nur Wibawa, Dayu Satriya Winarningsih, Wiwik