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All Journal Jurnal Buana Farma Health & Medical Sciences Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK)
Mo’o, Faradila Ratu Cindana
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Buana Farma

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UJI KUALITATIF BAHAN PENYUSUN SEDIAAN MIKROSFER BSA DENGAN KITOSAN DAN NA-TPP Anggai, Rifka Anggraini; Mo’o, Faradila Ratu Cindana
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1394

Abstract

This study aims to evaluate the qualitative characteristics of the components used in a protein delivery system based on microspheres, namely Bovine Serum Albumin (BSA), chitosan, sodium tripolyphosphate (Na-TPP), and maltodextrin, through organoleptic examination, Fourier Transform Infrared Spectroscopy (FTIR), and Differential Thermal Analysis (DTA). Organoleptic observations confirmed that all materials met standard physical characteristics as described in recent literature. FTIR spectra of BSA revealed the presence of amide I and II bands, indicating the preservation of its secondary protein structure. Chitosan exhibited functional groups capable of forming ionic crosslinks with TPP, essential in microsphere formation. The FTIR spectrum of TPP showed characteristic P=O and P–O–P absorption bands, confirming its role in ionic gelation. Maltodextrin displayed hydroxyl and carbonyl groups, supporting its function as a stabilizer in the formulation. DTA results demonstrated that all materials possess adequate thermal stability to withstand the formulation process. These findings suggest that the combination of BSA, chitosan, Na-TPP, and maltodextrin is compatible and effective in developing a stable microsphere-based protein delivery system, both in terms of chemical structure and thermal behavior.
Co-Authors Alpian Panu, Muhamad Anggai, Rifka Anggraini Endah Nurrohwinta Djuwarno LATIF, MULTIANI S Madania Nur Ain Thomas Nur Rasdianah Pakaya, Lutfiah Siti Marhamah, Siti Suryadi, A. Mu'thi Andy Teti Sutriyati Tuloli Yasin, Sulistya