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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmiah Medicamento
Mahardika, I Made Agus
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Environmental Science Health Professions Medicine & Pharmacology Public Health

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Uji Aktivitas Antiinflamasi Ekstrak Daun Benalu Jeruk (Dendrophthoe glabrescens (Blakely) Barlow) terhadap Mencit (Mus musculus) yang Diinduksi Karagenan Udayani, Ni Nyoman Wahyu; Mahendra, I Putu Aldy; Widiasriani, Ida Ayu Putu; Mahardika, I Made Agus; Wardani, I Gusti Agung Ayu Kusuma
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11434

Abstract

Inflammation is a natural defense mechanism of the body against injury or disease; however, excessive inflammation can lead to various chronic conditions. Prolonged use of synthetic anti-inflammatory drugs is associated with adverse effects, creating a need for safer natural alternatives. One such candidate is the citrus benalu leaf (Dendrophthoe glabrescens (Blakely) Barlow), a parasitic plant rich in flavonoids, saponins, and tannins. This study aimed to evaluate the anti-inflammatory activity of ethanol extract from citrus benalu leaves in carrageenan-induced mice. A laboratory experimental design using a Randomized Pre- and Post-Test Control Group approach was employed with 25 mice divided into five groups: negative control (CMC-Na 0.5%), positive control (sodium diclofenac), and three treatment groups receiving citrus benalu leaf extract at doses of 100, 200, and 400 mg/kgBW, respectively. The extract was administered orally 30 minutes after carrageenan induction, and paw edema was measured every 30 minutes for 180 minutes. One-way ANOVA revealed significant differences among groups, and LSD post hoc analysis indicated that all treatment groups differed significantly from the negative control (p < 0.05) but not from the positive control (p > 0.05). The 400 mg/kgBW dose demonstrated the greatest efficacy, reducing paw edema to 3.08%. These findings suggest that citrus benalu leaf extract has promising potential as a natural anti-inflammatory agent, offering an alternative to synthetic drugs with fewer side effects.
Eucheuma cottonii as a Natural Source for Type-2 Diabetes Mellitus Management: A Narrative review Mahardika, I Made Agus; Samirana, Putu Oka
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12689

Abstract

Background: Type 2 diabetes mellitus is a chronic metabolic disorder with a steadily increasing prevalence worldwide, including in Indonesia. Standard therapeutic approaches for T2DM are commonly associated with adverse effects, which has led to increasing interest in the use of herbal products and nutraceuticals. Eucheuma cottonii, an abundant red seaweed species in Indonesian waters, holds considerable potential as a preventive and therapeutic agent for T2DM due to its bioactive compound content.Objective: This study aimed to evaluate the potential of E. cottonii as a therapeutic agent through a literature review. Methods: This study is a literature review. Relevant literature was collected from several databases using specific keywords, and a total of 30 articles that met the inclusion criteria were selected for analysis.Results: Evidence suggested that E. cottonii comprises numerous bioactive substances compounds including flavonoids, phenolics, sulfated polysaccharides, and carrageenan, which demonstrate antidiabetic activity through multiple mechanisms. These compounds inhibit α-amylase and α-glucosidase enzymes, lower blood glucose levels, and enhance insulin secretion via dipeptidyl peptidase-4 inhibition. The antioxidant activity of E. cottonii is demonstrated by elevated levels of endogenous enzymes (SOD, GPx, GSH) and reduced ROS and MDA, while its anti-inflammatory effects were reflected in decreased expression of pro-inflammatory cytokines and inflammatory enzymes (COX-2, LOX-5). Moreover, E. cottonii functions as a prebiotic, modulating gut microbiota, enhancing the population of Bifidobacterium spp., and improving the Firmicutes/Bacteroidetes ratio, thereby contributing to better glucose metabolism.Conclusion: Based on these bioactivities, E. cottonii demonstrates strong potential for development as a multifunctional nutraceutical for the prevention and management of T2DM through antihyperglycemic, antioxidant, anti-inflammatory, and gut microbiota–modulating mechanisms.
Aktivitas Anti-Inflamasi Minyak Herbal Tradisional Dari Bahan Usada Bali Pada Mencit Inflamasi Yang Diinduksi Karagenan Yuda, Putu Era Sandhi Kusuma; Mahardika, I Made Agus; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes; Nayaka, Ni Made Dwi Mara Widyani; Dewi, Ni Luh Kade Arman Anita
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 3 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i3.60529

Abstract

Peradangan sendi atau artritis merupakan salah satu penyakit inflamasi kronis yang memerlukan penggunaan obat jangka panjang. Penggunaan obat artritis seperti metotreksat dan NSAID dalam waktu lama dapat menimbulkan berbagai efek samping serius, sehingga diperlukan alternatif pengobatan yang relatif lebih aman terutama dari bahan herbal. Penelitian ini dilakukan untuk menguji aktivitas anti-inflamasi minyak herbal tradisional Usada Bali dari bahan Jahe (Zingiber officinale), Kunyit (Curcuma longa), Kencur (Kaemferia galanga), Bangle (Zingiber montanum), Cengkeh (Syzigium aromaticum) dan Kayu Manis (Cinnamomum burmanii) pada mencit inflamasi yang diinduksi karagenan melalui pengujian secara topikal. Mencit dibagi empat kelompok yang terdiri dari kelompok kontrol negatif (pembawa), kontrol positif (Natrium Diklofenak topikal), minyak herbal 150 dan 300 mg/ml. Volume peradangan kaki mencit diukur dengan alat pletismometer setiap jam selama empat jam setelah diinduksi dengan karagenan 0,5% (b/v) subplantar, kemudian diuji secara statistik (Mann-Whitney) dengan taraf kepercayaan 95%. Skrining fitokimia menunjukkan bahwa minyak herbal mengandung senyawa flavonoid, terpenoid dan steroid. Hasil uji aktivitas anti-inflamasi menunjukan adanya penghambatan peradangan yang signifikan (p<0,05) oleh minyak herbal konsentrasi 150 mg/ml maupun 300 mg/ml dengan persentase penghambatan pada jam ke-4 masing-masing sebesar 16,52% dan 11,30%, serta tidak berbeda bermakna dibandingkan kontrol positif (p>0,05). Hasil tersebut menunjukkan adanya potensi  minyak herbal Usada Bali sebagai anti-inflamasi topikal.
Co-Authors Erna Cahyaningsih Mahendra, I Putu Aldy Ni Luh Kade Arman Anita Dewi Ni Made Dwi Mara Widyani Nayaka Ni Nyoman Wahyu Udayani Putu Era Sandhi Kusuma Yuda Putu Oka Samirana Sasadara, Maria Malida Vernandes Wardani, I Gusti Agung Ayu Kusuma Widiasriani, Ida Ayu Putu