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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Ners Jurnal Sains dan Teknologi Jurnal Sains dan Kesehatan Journal of Pharmaceutical and Sciences.
Watora, Wahyuni
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Analisis Pemakaian BMHP pada Pasien Persalinan Normal, Operasi Caesar Umum, Dan BPJS di RSUD Sorong Levina Virginia; Lukman Hardia; Watora, Wahyuni
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 5 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i5.6395

Abstract

Disposable Medical Materials play an important role in maternity services and their use is influenced by the type of delivery and the patient's payment method. This study aims to analyze the influence of both on the use of disposable medical materials in the Emergency Department Pharmacy and the Medical Depot of Dr. J.P. Wanane Regional General Hospital, Sorong Regency, and to comparing the use of disposable medical materials between caesarean section patients of the social security administration and general normal delivery. This quantitative cross-sectional study used a total sampling of 108 delivery patients from January 2025 to June 2025. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests (α=5%). The Kruskal-Wallis test results showed a significant difference in the use of medical consumables between patient groups based on the combination of delivery type and payment method (p = 0.011). Caesarean section patients from the Social Security Administration used the most medical consumables, while patients with normal delivery used the least. Mann-Whitney analysis confirmed that the use of medical consumables was higher among Caesarean section patients from the Social Security Administration compared to normal delivery (p = 0.007). Thus, the type of delivery and payment method had a significant influence, with the highest use of medical consumables among Caesarean section patients from the Social Security Administration. It was concluded that the type of delivery and payment method had a significant effect, with the highest use of disposable medical materials in the social security administration caesarean section patients.
Pengaruh Konsentrasi Ekstrak Etanol Metimun (Cucumis sativus L.) Terhadap Konsentrasi Antioksidan dalam Sediaan Masker Gel Peel Off Fransiska, Gilda; Watora, Wahyuni; Hardia, Lukman
Jurnal Sains & Kesehatan Vol 4 No 2 (2025): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v4i2.1590

Abstract

Salah satu tanaman yang berpotensi sebagai sumber antioksidan alami adalah mentimun (Cucumis sativus L.). Kandungan air yang tinggi serta keberadaan vitamin C dan flavonoid di dalam mentimun berperan dalam aktivitas antioksidan dengan mekanisme menghambat, menangkap, maupun memutus reaksi radikal bebas yang bersifat sangat reaktif dan dapat memicu terbentuknya radikal bebas baru. Berdasarkan hasil uji fitokimia, ekstrak mentimun diketahui mengandung beberapa senyawa metabolit sekunder, seperti alkaloid, flavonoid dan saponin. Pemanfaatan bahan tersebut sebagai sediaan kosmetik berbentuk masker gel peel off dinilai sangat tepat. Jenis masker ini memiliki keunggulan dari segi kepraktisan karena setelah mengering dapat dilepaskan langsung dari permukaan kulit tanpa harus dibilas terlebih dahulu. Penelitian ini bertujuan untuk menganalisis pengaruh perbedaan konsentrasi ekstrak etanol mentimun (Cucumis sativus L.) yang diformulasikan dalam masker gel peel off terhadap aktivitas antioksidan yang dihasilkan. Metode yang digunakan adalah metode DPPH (2,2-diphenyl-1-picrylhydrazil atau 1,1-diphenyl-2-picrylhydrazil). Sediaan masker gel peel off diformulasikan dengan variasi konsentrasi ekstrak, yaitu 0,5% pada formula I, 1% pada formula II, dan 1,5% pada formula III. Nilai IC₅₀ yang diperoleh dari pengujian masker gel peel off pada F1 dengan konsentrasi ekstrak 0,5% menunjukkan hasil bernilai negatif sehingga IC₅₀ tidak dapat ditentukan, sedangkan ekstrak 1% (F2) memiliki nilai IC₅₀ sebesar 230,7 ppm dan ekstrak 1,5% (F3) sebesar 79,29 ppm, yang menunjukan peningkatan aktivitas antioksidan seiring dengan meningkatnya konsentrasi ekstrak dalam sediaan masker.
Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Rossardy, Marzella Dea; Muslihin, A.M.; Watora, Wahyuni; Budiyanto, Angga Bayu; Hardia, Lukman; Irwandi, Irwandi; Aponno, Alyssa Mileta; Utami, Hikmahtul Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
Evaluasi Kelengkapan Administrasi dan Farmasetik Resep di Apotek Kimia Farma A. Yani Kota Sorong Ernifan, Ernifan; Hardia, Lukman; Watora, Wahyuni
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.56679

Abstract

Abstrak Kelengkapan administrasi dan farmasetik pada resep merupakan tahapan penting dalam pelayanan kefarmasian untuk menjamin keselamatan pasien serta meminimalkan risiko medication error. Seiring dengan meningkatnya jumlah apotek di Indonesia, tuntutan terhadap mutu pelayanan kefarmasian juga semakin tinggi, khususnya dalam proses skrining resep. Penelitian ini bertujuan untuk mengevaluasi tingkat kelengkapan administrasi dan farmasetik resep di Apotek Kimia Farma A. Yani Kota Sorong pada periode Januari–Desember 2024. Sampel penelitian terdiri atas 370 lembar resep untuk evaluasi aspek administrasi dan 689 item obat untuk evaluasi aspek farmasetik. Analisis data dilakukan secara deskriptif dengan menghitung persentase kelengkapan masing-masing komponen yang diteliti. Hasil penelitian menunjukkan bahwa seluruh resep (100%) mencantumkan nama pasien, jenis kelamin (52,7%), umur (46,2%), berat badan pasien (11,1%), dan alamat pasien (9,7%). Pada aspek identitas dokter, sebanyak 97,5% resep mencantumkan nama dokter dan 100% mencantumkan alamat praktik, sedangkan nomor Surat Izin Praktik (SIP) hanya tercantum pada 11,1% resep dan nomor telepon dokter pada 4,6% resep. Tanggal penulisan resep ditemukan pada 97,8% resep. Dari aspek farmasetik, sebanyak 73,9% resep memenuhi kriteria kelengkapan. Seluruh item obat (100%) mencantumkan jumlah obat yang diresepkan, dan 97% mencantumkan aturan pakai. Namun demikian, hanya 59,9% item obat yang mencantumkan bentuk sediaan dan 38,8% yang mencantumkan kekuatan sediaan. Temuan ini menunjukkan bahwa meskipun beberapa komponen telah terpenuhi dengan baik, masih terdapat kekurangan pada aspek administrasi dan farmasetik tertentu yang berpotensi meningkatkan risiko kesalahan pengobatan. Oleh karena itu, diperlukan upaya peningkatan kepatuhan terhadap standar penulisan resep guna meningkatkan mutu pelayanan kefarmasian. Kata kunci: aspek administrasi, aspek farmasetik, kelengkapan resep, medication error, pelayanan kefarmasian.
Efficacy of Akway (Drymis sp.) Bark Extract in Restoring Hemoglobin Levels: A Preclinical Study in a Sodium Nitrite-Induced Anemia Mice Model Lukman Hardia; Fabanyo, Syahrul H.; Budiyanto, Angga Bayu; Muslihin, A. M.; Rossardy, Marzella Dea; Irwandi, Irwandi; Watora, Wahyuni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44062

Abstract

The high prevalence of anemia prompted us to explore the potential of local herbs in Papua, Indonesia, which is known for its rich natural resources. In this study, we aim to conduct preclinical tests on anemia model test animals to validate the effectiveness of akway bark extract (ABE) as the basis for the development of effective and safe herbal antianemia drugs in the future. This study employs a quantitative analytical approach, utilizing an experimental design with a pre-posttest with a control group design. The research sample used 20 mice test animals, divided into 5 groups consisting of 4 animals each, namely: the control group (positive and negative), and the intervention group using ABE doses of 10, 30, and 50mg/kg. This study was approved by the Health Research Ethics Committee of STIFAR Makassar (Number: 299/EC.1.1.B/III/KEPK/2024). Data analysis showed that a 14-day intervention using ABE was able to increase Hb levels (D% = 52.00±27.13 [ABE dose 10mg/kg]; 49.72±7.86 [ABE dose 50mg/kg] and 42.82±12.75 [ABE dose 30mg/kg]) significantly (p<0.05) when compared with the negative control (D% = 4.54±5.14), but when compared with the positive control (D% = 52.57±10.85) the average increase in Hb levels was not significant (p>0.05). In conclusion, our study showed that mice of the anemia model, intervened using ABE at doses of 10, 30, and 50mg/kg once daily for 14 days, experienced increased Hb levels.
Studi Etnofarmasi dan Skrining Fitokimia Kulit Batang Nelambo Suon (Rubiceae) Sebagai Antimalaria Suku Tehit Papua Watora, Wahyuni; Astuti, Ratih Arum; Rossardy, Marzella Dea
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.54145

Abstract

Abstrak Malaria masih menjadi permasalahan kesehatan di wilayah Papua, sehingga pemanfaatan tumbuhan obat tradisional tetap menjadi pilihan utama masyarakat pedalaman. Penelitian ini bertujuan untuk mendeskripsikan pemanfaatan tradisional tumbuhan Nelambo suon oleh masyarakat Suku Tehit di Distrik Teminabuan, Kabupaten Sorong Selatan, serta mengidentifikasi kandungan metabolit sekundernya melalui skrining fitokimia. Penelitian dilakukan melalui wawancara mendalam kepada informan lokal untuk memperoleh data pengetahuan, pengalaman, cara penggunaan, dan keyakinan terhadap efektivitas tanaman tersebut, serta uji fitokimia secara kualitatif terhadap ekstrak kulit batang. Hasil penelitian menunjukkan bahwa kulit batang Nelambo suon secara turun-temurun digunakan sebagai obat antimalaria, dengan cara direbus dan airnya diminum dua kali sehari hingga gejala berkurang. Analisis responden menunjukkan bahwa tingkat pengetahuan dan pengalaman tertinggi terdapat pada kelompok berpendidikan rendah (SD dan SMP), menandakan bahwa pengetahuan tradisional lebih dipengaruhi oleh pewarisan budaya dibandingkan pendidikan formal. Hasil skrining fitokimia menunjukkan adanya kandungan alkaloid, flavonoid, dan tanin, sedangkan saponin tidak terdeteksi. Senyawa-senyawa ini diketahui memiliki aktivitas antiplasmodium, antioksidan, serta antiinflamasi, sehingga mendukung potensi Nelambo suon sebagai kandidat obat tradisional antimalaria berbasis kearifan lokal. Kata Kunci: Etnofarmasi, Nelambo suon, antimalaria, skrining fitokimia. Abstract Malaria remains a major health problem in papua, making traditional medicinal plants an essential therapeutic option for remote communities. this study aims to describe the traditional use of nelambo suon by the tehit community in teminabuan district, south sorong regency, and to identify its secondary metabolites through phytochemical screening. data on traditional knowledge, experience, usage methods, and beliefs were collected through in-depth interviews with local informants, while qualitative phytochemical tests were performed on the stem bark extract. the results show that nelambo suon has been traditionally used for generations as an antimalarial remedy, prepared by boiling the stem bark and consuming the decoction twice daily until symptoms reduce. respondent analysis revealed that the highest levels of traditional knowledge and experience were found among those with lower formal education (elementary and junior high school), indicating that cultural transmission plays a greater role than formal schooling. phytochemical screening confirmed the presence of alkaloids, flavonoids, and tannins, while saponins were absent. these compounds possess antiplasmodial, antioxidant, and anti-inflammatory activities, supporting the potential of nelambo suon as a traditional antimalarial agent grounded in local wisdom. Keywords: ethnopharmacy, Nelambo suon, antimalarial, phytochemical screening.
Efektivitas Kulit Buah Naga Merah (Hylocereus Polyrhizus) sebagai Antikolesterol Hardia, Lukman; Fadil Nadila, Rizqi; Watora, Wahyuni
Jurnal Sains & Kesehatan Vol 5 No 1 (2026): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v5i1.1698

Abstract

Hypercholesterolemia is a condition where blood cholesterol levels exceed normal limits, becoming a risk factor for coronary heart disease. The skin of the red dragon fruit (Hylocereus polyrhizus) contains flavonoids, betayanin, and dietary fiber that have the potential to lower cholesterol levels. This study aims to determine the effectiveness and optimal dose of red dragon fruit peel extract as a cholesterol lowering in white rats of the Wistar strain (Rattus novergicus) induced by high cholesterol feed. This study used the pretest and post-test with control group design method, with 25 mice divided into 5 groups: negative control, positive control (simvastatin 10mg) and treatment groups with extract doses of 15, 30, and 60 mg/kg BB. The results showed that red dragon fruit peel extract had the effectiveness of hypercholesterolemia with a dose of 60mg/kgBB providing the most optimal reducing effect. Conclusion: Ethanol extract of red dragon fruit peel can significantly lower cholesterol levels in rats with hypercholesterolemia.
Co-Authors A. M. Muslihin Angga Bayu Budiyanto Aponno, Alyssa Mileta Astuti, Ratih Arum Ernifan, Ernifan Fabanyo, Syahrul H. Fadil Nadila, Rizqi Fransiska, Gilda Irwandi Irwandi Levina Virginia Lukman Hardia Rossardy, Marzella Dea Utami, Hikmahtul Putri