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SARS-CoV-2 Antibody Seroprevalence in Jakarta, Indonesia Ariawan, Iwan; Jusril, Hafizah; N Farid, Muhammad; Riono, Pandu; Wahyuningsih, Wiji; Widyastuti, Widyastuti; Handayani, Dwi Oktavia T L; Wahyuningsih, Endang Sri; Daulay, Rebekka; Henderiawati, Retno; Malik, Safarina G; Noviyanti, Rintis; Trianty, Leily; Fadila, Nadia; Myint, Khin Saw Aye; Yudhaputri, Frilasita A.; Venkateswaran, Neeraja; Venkateswaran, Kodumudi; Udhayakumar, Venkatachalam; Hawley, William A.; Morgan, Juliette; Pronyk, Paul M
Kesmas Vol. 17, No. 3
Publisher : UI Scholars Hub

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Abstract

The SARS-CoV-2 transmission dynamics in low- and middle-income countries remain poorly understood. This study aimed to estimate the SARS-CoV-2 antibodies seroprevalence in Jakarta, Indonesia, and to increase knowledge of SARS-CoV-2 transmission in urban settings. A population-based serosurvey among individuals aged one year or older was conducted in Jakarta. Employing a multistage sampling design, samples were stratified by district, slum, and non-slum residency, sex, and age group. Blood samples were tested for IgG against three different SARS-CoV-2 antigens. Seroprevalence was estimated after applying sample weights and adjusting for cluster characteristics. In March 2021, this study collected 4,919 respondents. The weighted estimate of seroprevalence was 44.5% (95% CI = 42.5-46.5). Seroprevalence was highest among adults aged 30-49 years, with higher seroprevalence in women and the overweight/obese group. Respondents residing in slum areas were 1.3-fold more likely to be seropositive than non-slum residents. It was estimated that4,717,000 of Jakarta's 10.6 million residents had prior SARS-CoV-2 infection. This suggests that approximately 10 infections were undiagnosed/underreported for every reported case. About one year after the first COVID-19 case was confirmed, close to half of Jakarta's residents have been infected by SARS-CoV-2.
Patterns and Determinants of Measles Among Suspected Cases in Jakarta: Insight from Surveillance Data 2022-2024 Inayah, Widya; Prihartono, Nurhayati Adnan; Henderiawati, Retno; Nugraheni, Oktaviana; Gayatri, Dwi
Jurnal Epidemiologi Kesehatan Indonesia
Publisher : UI Scholars Hub

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Abstract

Measles remains a public health concern in Indonesia, including Jakarta, contributing to the country’s disease burden. Sustained transmission during 2022-2024, despite reported vaccination coverage above  90%, suggests the presence of vulnerable groups. This study aimed to describe patterns and identify factors associated with laboratory-confirmed measles in Jakarta during 2022-2024. A cross-sectional study was conducted using routine surveillance data from all individuals reported as suspected measles cases during the study period. Descriptive analysis summarizes the distribution, while multivariable analysis identifies associated factors. Of the 4,194 suspected cases of measles, 22.8% were laboratory-confirmed positive. Showed a fluctuating temporal pattern, increasing from 20.6 % in 2022 to 42% in 2023, followed by a sharp decline to 3.5% in 2024. Among reported suspected measles cases, children aged ≤ 5 years had higher odds of laboratory-confirmed measles than those aged >5 years (aPOR 1.38; 95% CI 1.17-1.63). Unvaccinated individuals had a higher odds of laboratory-confirmed measles than fully vaccinated individuals (aPOR 2.53; 95% CI 2.09-3.06). Sex and travel history were not associated. Measles transmission in Jakarta persisted with a fluctuating pattern and was associated with children aged 5 and younger and unvaccinated individuals. Strengthening routine measles immunization and prioritizing susceptible groups identified through surveillance data are needed. Keywords: Measles, Surveillance, Risk Factors, Vaccine-Preventable Disease