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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan
Hammami, Akmal
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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LITERATURE REVIEW: PHARMACOLOGICAL AND TOXICOLOGICAL EFFECTS OF PLANTS FROM THE SOLANACEAE FAMILY Damayanti Abdul Karim, Dewi; Safutri, Wina; Hammami, Akmal; Ayu Chandra, Ananda
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2417

Abstract

Solanaceae is a family of flowering plants with 83 genera and 2,925 species spread throughout the world. People reuse natural medicines that have been passed down from generation to generation because medical medicines have a big tendency to cause many side effects. This research aims to examine the pharmacological effects and toxicity of plants in the Solanaceae family. This research used 10 plant species, including potatoes (Solanum tuberosum L.), golden berries (Physalis angulata L.), tomatoes (Solanum lycopersicum L.), red chilies (Capsicum annuum L.), cayenne peppers (Capsicum frutescens L.), tobacco (Nicotiana tabacum L.), paprika (Capsicum annuum var. grossum), amethyst (Datura stramonium L.), Turkey berry (Solanum torvum Sw.), and black nightshades (Solanum nigrum L.). The journal search method used in this research is the Boolean System method (AND and OR) using the Google Scholar and Sinta databases. The results obtained from this research were that among the 10 plant species of the Solanaceae family studied, there were 3 pharmacological effects with the most data modes, including antimicrobial, anti-inflammatory, and anti-oxidant effects.
Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

Abstract

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.
Co-Authors Ayu Chandra, Ananda Damayanti Abdul Karim, Dewi intan kusuma wardani Nabila, Novrilia Atika Rahayyu, Annisa Maulidia Simanullang, Gayatri Wina Safutri