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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan
Hammami, Akmal
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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LITERATURE REVIEW: PHARMACOLOGICAL AND TOXICOLOGICAL EFFECTS OF PLANTS FROM THE SOLANACEAE FAMILY Damayanti Abdul Karim, Dewi; Safutri, Wina; Hammami, Akmal; Ayu Chandra, Ananda
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2417

Abstract

Solanaceae is a family of flowering plants with 83 genera and 2,925 species spread throughout the world. People reuse natural medicines that have been passed down from generation to generation because medical medicines have a big tendency to cause many side effects. This research aims to examine the pharmacological effects and toxicity of plants in the Solanaceae family. This research used 10 plant species, including potatoes (Solanum tuberosum L.), golden berries (Physalis angulata L.), tomatoes (Solanum lycopersicum L.), red chilies (Capsicum annuum L.), cayenne peppers (Capsicum frutescens L.), tobacco (Nicotiana tabacum L.), paprika (Capsicum annuum var. grossum), amethyst (Datura stramonium L.), Turkey berry (Solanum torvum Sw.), and black nightshades (Solanum nigrum L.). The journal search method used in this research is the Boolean System method (AND and OR) using the Google Scholar and Sinta databases. The results obtained from this research were that among the 10 plant species of the Solanaceae family studied, there were 3 pharmacological effects with the most data modes, including antimicrobial, anti-inflammatory, and anti-oxidant effects.
Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

Abstract

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.
Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

Abstract

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.
Uji Aktivitas Hepatoprotektor Tablet Curcuma® terhadap Kadar SGPT dan SGOT pada Tikus yang Diinduksi Isoniazid Simanullang, Gayatri; Nabila, Novrilia Atika; Rahayyu, Annisa Maulidia; Wardani, Intan Kusuma; Hammami, Akmal
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.848

Abstract

Isoniazid (INH) merupakan obat anti tuberkulosis yang penggunaannya dapat menimbulkan efek samping berupa hepatotoksisitas. Kondisi ini dapat dipantau melalui peningkatan kadar enzim hati, yaitu serum glutamic pyruvic transaminase (SGPT) dan serum glutamic oxaloacetic transaminase (SGOT). Oleh karena itu, diperlukan suatu agen pelindung untuk meminimalisir efek samping hepatotoksik yang ditimbulkan. Temulawak (Curcuma xanthorrhiza Roxb.) dikenal memiliki aktivitas hepatoprotektor yang berpotensi melindungi hati dari kerusakan. Berdasarkan hal tersebut, penelitian ini bertujuan untuk mengetahui pengaruh pemberian sediaan tablet Curcuma® terhadap kadar SGPT dan SGOT pada tikus putih jantan yang diinduksi INH, serta menganalisis korelasi antara dosis Curcuma® dengan penurunan kadar kedua enzim hati tersebut. Metode pada penelitian ini yaitu menggunakan hewan uji berupa tikus putih jantan yang dibagi menjadi tiga kelompok dengan pemberian dosis INH yang sama: kelompok 1 diberikan INH 5,4 mg/kgBB, kelompok 2 curcuma® 0,36 mg/kgBB + INH, dan kelompok 3 curcuma® 0,72 mg/kgBB + INH. Perlakuan diberikan selama 14 hari secara oral untuk diukur kadar SGPT dan SGOT, rasio berat hati, serta pengamatan makroskopis hati. Hasil penelitian menunjukkan bahwa pemberian curcuma® memberikan efek yang berbeda pada kelompok 2 dan 3. Pada kelompok 3, kadar SGPT dan SGOT mengalami penurunan. Sedangkan, pada kelompok 2 hanya kadar SGPT yang menurun, untuk kadar SGOT mengalami peningkatan. Meskipun demikian, perbedaan penurunan kadar SGPT dan SGOT antara kedua kelompok tidak terdapat perbedaan yang signifikan secara statistik (p > 0,05). Rasio hati pada kelompok 1 (3,16%), kelompok 2 (2,83%), dan kelompok 3 (2,71%). Rasio hati pada kelompok 3 menunjukkan persentase yang lebih rendah dibandingkan kelompok perlakuan lainnya. Secara makroskopis, hati pada kelompok 3 memiliki warna segar, licin, dan kenyal, mendekati kondisi hati normal. Pemberian sediaan tablet curcuma® mampu melindungi hati dari kerusakan karena memiliki potensi sebagai hepatoprotektor terhadap tikus putih jantan yang diinduksi isoniazid.
Co-Authors Ayu Chandra, Ananda Damayanti Abdul Karim, Dewi intan kusuma wardani Nabila, Novrilia Atika Rahayyu, Annisa Maulidia Simanullang, Gayatri Wina Safutri