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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat JOMPA ABDI: Jurnal Pengabdian Masyarakat JPEMAS: Jurnal Pengabdian Kepada Masyarakat
Simanullang, Gayatri
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Diversifikasi Makanan Gizi Seimbang Dari Hasil Pertanian Desa Sukabanjar, Pesawaran sebagai Pangan Pencegah Stunting Auli, Wini Nur; Simanullang, Gayatri; Nasution, Syahrizal; Rahayu, Ihsanti Dwi; Ulandari, Atri Sri
Jompa Abdi: Jurnal Pengabdian Masyarakat Vol. 3 No. 4 (2024): Jompa Abdi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jompaabdi.v3i4.1244

Abstract

Stunting merupakan gangguan pertumbuhan fisik yang ditandai dengan berkurangnya laju pertumbuhan dan diakibatkan oleh ketidakseimbangan gizi. Tujuan pengabdian masyarakat ini yaitu melakukan pemberdayaan pentingnya gizi seimbang untuk mencegah stunting serta pelatihan pembuatan produk nugget dan yoghurt sebagai sumber protein. Pengabdian ini dilaksanakan pada 22 Agustus 2024. Tahapan pengabdian dilaksanakan melalui optimasi dan trial produk, pengerjaan pre-test, penyampaian materi, pelatihan pembuatan produk, serta pengerjaan post-test dan evaluasi. Pengabdian ini menghasilkan peningkatan pengetahuan masyarakat terkait stunting serta keterampilan terkait pembuatan produk nugget dan yoghurt. Pengetahuan masyarakat meningkat meliputi penyebab utama, dampak jangka panjang, kandungan gizi penting, dan contoh pangan terkait stunting. Kegiatan pemberdayaan masyarakat secara berkelanjutan penting untuk dilaksanakan di berbagai desa dengan memanfaatkan potensi lokal.
DETEKSI DINI ANEMIA LEWAT SKRINING DAN KONSELING SISWA SMA MUHAMMADIYAH 2 BANDAR LAMPUNG Janu, Juwana; Marhiyani, Dini; Dirga, Dirga; Windari, Nurul Irna; Hidayaturahmah, Rizky; Simanullang, Gayatri; Hasanah , Uswatun
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 6 No. 4 (2025): Volume 6 No 4 Tahun 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v6i4.47310

Abstract

Anemia merupakan permasalahan kesehatan global yang berdampak pada berbagai kelompok usia, termasuk remaja putri. Hemoglobin berperan penting dalam pengangkutan oksigen serta menjaga kesehatan tubuh secara keseluruhan. Kegiatan skrining anemia dilakukan di SMA Muhammadiyah 2 Bandar Lampung, yang dipilih karena memiliki populasi siswa yang representatif dan belum pernah dilakukan skrining sebelumnya. Nilai Indeks Massa Tubuh (IMT) diperoleh melalui pengukuran berat dan tinggi badan, tekanan darah diukur menggunakan sphygmomanometer digital, dan kadar hemoglobin diperiksa dengan metode Point of Care Testing. Hasil pemeriksaan yang dilakukan pada peserta dengan rerata usia 16 tahun, menunjukkan bahwa 68,42% peserta memiliki kadar hemoglobin normal, sementara 21.05% mengalami anemia ringan, 10,53% anemia sedang. Tekanan darah normal ditemukan pada 57,90% peserta, 31,60% dalam kategori prehipertensi, dan 5,30% mengalami hipertensi tingkat 1 maupun 2. Hasil deteksi dini ini menegaskan perlunya edukasi lebih lanjut mengenai pola makan sehat dan pencegahan hipertensi sejak remaja. Kegiatan ini diharapkan dapat meningkatkan kesadaran kesehatan dan menjadi dasar untuk intervensi gizi yang berkelanjutan guna mencegah risiko anemia serta hipertensi di masa mendatang.
Pelatihan Pemanfaatan Limbah Rambut Jagung Sebagai Produk Pangan Fungsional Di Desa Banjar Agung, Lampung Selatan Rahayyu, Annisa Maulidia; Simanullang, Gayatri; Sari, Untia Kartika; Nareswari, Tantri Liris; Setyawan, Irfanianta Arif
JPEMAS: Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 1 (2022): JPEMAS : Jurnal Pengabdian Kepada Masyarakat
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71456/adc.v1i1.68

Abstract

Desa Banjar Agung masuk dalam kecamatan wilayah kabupaten Lampung Selatan yang merupakan salah satu daerah penghasil jagung. Selama ini limbah yang dihasilkan dari pengolahan paska panen, yaitu rambut jagung belum dimanfaatkan secara baik, padahal rambut jagung memiliki kandungan antioksidan dan berpotensi untuk diolah menjadi produk pangan fungsional. Berdasarkan hasil survei dan diskusi dengan perangkat desa Banjar Agung ditemukan beberapa permasalahan, seperti minimnya pengetahuan dan ketrampilan masyarakat dalam mengolah dan memasarkan rambut jagung menjadi produk pangan fungsional. Kegiatan yang dilakukan adalah memberikan penyuluhan serta pelatihan pengolahan rambut jagung menjadi produk pangan fungsional seperti sirup, agar-agar, dan es lilin, serta pendampingan digital marketing. Target peserta kegiatan adalah ibu-ibu PKK dan pengurus UMKM di Desa Banjar Agung. Terdapat 26 orang yang hadir dengan 6 diantaranya adalah perangkat desa. Hasil yang didapat dari penilaian pre-test dan post-test adalah 20 orang mengalami persentase kenaikan nilai rata-rata sebesar 25%, sedangkan 2 diantaranya bernilai tetap dengan nilai 90 dan 80 dari 100. Hasil luaran lain dari kegiatan ini adalah produk pangan fungsional, poster, video, publikasi di media elektronik serta jurnal pengabdian masyarakat
Uji Stabilitas dan Aktivitas Sediaan Patch Herbal Anti-Acne Ekstrak Etanol Daun Gaharu Simanullang, Gayatri; Ramadhani, Untia Kartika Sari; Suprahman, Nisa Yulianti; Maretta, Gres; Syafitri, Dewi Rana; Saeli, Pinka Mustika; Ashafila, Tsalsha
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.439

Abstract

Acne is a skin condition characterized by the formation of skin bumps due to bacterial activity. Secondary metabolite compounds found in Gaharu leaves, such as flavonoids known for their antibacterial properties. This research aims to assess the physical and chemical stability of an anti-acne patch containing ethanol extract from Gaharu leaves and chitosan polymer. Additionally, this research aims to evaluate the antibacterial effectiveness of the anti-acne patch against Propionibacterium acnes. The experimental approach involves stability testing through cycling tests, observation of physical and chemical properties before and after stability tests, and antibacterial activity testing against P. acnes. The results from the stability test indicate overall stability in organoleptic aspects, thickness, folding ability, weight consistency, moisture content, vapor transmission, and moisture absorption of the anti-acne patch. However, instability is noted in the pH of the preparation. The antibacterial activity test reveals that the entire formulation exhibits antibacterial properties against P. acnes. Furthermore, there is a positive correlation between the increased concentration of ethanol extract from Gaharu leaves or chitosan polymer and the heightened barrier zone value.
Formulasi Gel Ekstrak Etanol Daun Awar-awar dan Evaluasi Aktivitas Anti-inflamasi secara In Vitro Khansa Nur Izzati; Simanullang, Gayatri; Riri Fauziyya
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.17741

Abstract

Gel is a semisolid dosage form that utilises a gelling agent, such as Carbopol 940, providing ease of application and efficient skin absorption. Ethanol extract of awar-awar (Ficus septica Burm. F) leaves, which contain flavonoids and tannins, has demonstrated promising anti-inflammatory potential. This study aimed to formulate and evaluate the stability of a gel containing the ethanol extract of awar-awar leaves, as well as assess its anti-inflammatory effects. The methods comprised phytochemical screening, gel formulation and evaluation, stability testing, and an in vitro anti-inflammatory assay. Four gel formulations were created: F0 (0%), F1 (1.5%), F2 (3%), and F3 (4.5%). Evaluation results showed that F0, F1, and F3 were homogeneous, with viscosities between 5,000-50,000 mPa·s, spreadability of 5-7 cm, and adhesion time exceeding 2 seconds, meeting Indonesian National Standard (SNI) requirements. However, pH testing during the cycling tests revealed instability in formulations F1 through F3 during storage. The anti-inflammatory test, conducted using the protein denaturation inhibition method, showed all three formulations had anti-inflammatory activity, with F3 being the most effective (92.20% inhibition). Therefore, F3 is considered the most promising formulation due to its high anti-inflammatory activity and acceptable pharmaceutical characteristics for gel preparations.
Ethanol Extract Burn Gel Formulation of Bay Leaves (Syzygium polyanthum (Wight.) Walp.) Dwi Ayu Andini, Annisa; Simanullang, Gayatri; Damayanti Abdul Karim, Dewi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 1 (2024): March 2024
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i1.2754

Abstract

Burns are skin tissue damage caused by hot objects or hot liquids. One of the potentially healing plants for burns is the bay leaves (Syzygium polyanthum (Wight.) Walp.). Bay leaves ethanol extract contains flavonoids known for their anti-inflammatory properties, which can aid in wound healing. This study aimed to determine the formulation and effectiveness of a gel made from ethanol bay leaves extract. Bay leaves were extracted using the maceration method with a 70% ethanol solvent; then, its extract was formulated into gel preparations. Following the formulation,the researchers conducted physicochemical evaluations and burn effectiveness trials using New Zealand albino rabbits. The research results indicated that the burn gel formulations with 3% and 6% concentration variations exhibited favourable physical properties, including organoleptic, homogeneity, and pH from 5.33 to 5.8, spreadability from 4.77 to 5.55 cm, adhesion strength from 5.47 to 11.6 seconds, and viscosity ranged from 12.507 to 16.080 cPs. The 15-day burn effectiveness test revealed no significant differences, indicating that the reduction in wound diameter was relatively consistent across all test groups. The percentages of wound healing in the negative control, bioplacentone, F1, and F2 were 42.48%, 54.73%, 43.84%, and 65.89%, respectively. Therefore, F2 demonstrated the best wound-healing performance.
Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

Abstract

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.
Co-Authors Ashafila, Tsalsha Atri Sri Ulandari Auli, Wini Nur Damayanti Abdul Karim, Dewi Dirga Dirga Dwi Ayu Andini, Annisa Gres Maretta, Gres Hammami, Akmal Hasanah , Uswatun Hidayaturahmah, Rizky Ihsanti Dwi Rahayu intan kusuma wardani Janu, Juwana Khansa Nur Izzati Marhiyani, Dini Nabila, Novrilia Atika Nisa Yulianti Suprahman Rahayyu, Annisa Maulidia Ramadhani, Untia Kartika Sari Riri Fauziyya Saeli, Pinka Mustika Sari, Untia Kartika Setyawan, Irfanianta Arif Syafitri, Dewi Rana Syahrizal Nasution Tantri Liris Nareswari Windari, Nurul Irna