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Nabila, Novrilia Atika
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Characteristics and evaluation of potential drug interactions among HIV/AIDS outpatients: a retrospective study at primary health center in a North Lampung regency, Indonesia Nabila, Novrilia Atika; Karim, Miska Aulia; Akhmad, Atika Dalili
Pharmacy Reports Vol. 5 No. 1 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.102

Abstract

People living with HIV/AIDS require lifelong antiretroviral therapy (ART) and frequently experience complications and comorbidities that raise the risk of drug-drug interactions. This study aimed to characterize the patients, describe their medication use, and identify potential drug interactions among HIV/AIDS patients at a primary health center in North Lampung Regency. We performed a retrospective, descriptive review of medical records from January to December 2024. All eligible HIV/AIDS patients (N = 31) were included via total sampling. Drug interaction screening used the Lexicomp® application and Stockley’s Drug Interactions. The results showed that most HIV/AIDS patients were male (74.19%), aged 36–45 years (41.93%), and classified as WHO clinical stage I (38.70%). The first‑line ART regimen TLE (tenofovir + lamivudine + efavirenz) was prescribed to 54.8% of patients. A total of 35 potential interactions were identified: 65.7% were moderate pharmacokinetic, 28.6% minor pharmacokinetic, and 5.7% pharmacodynamic (2.9% major and 2.9% moderate). Moderate pharmacokinetic interactions predominated, underscoring the importance of proactive screening and ongoing medication review by pharmacists to prevent adverse events and optimize therapy in HIV/AIDS care.
PELATIHAN INOVASI OLAHAN COKLAT MENJADI SELAI DAN MASKER COKLAT UNTUK MASYARAKAT DESA TARAHAN Nabila, Novrilia Atika; Tantri Liris Nareswari; Auli, Winni Nur; Rahayyu, Annisa Maulidia; Rooswita, Putri Amelia; Hidayaturahmah, Rizky
JURNAL ABDIMAS DOSMA (JAD) Vol. 3 No. 2 (2024): JUNI
Publisher : IKATAN ALUMNI DOSEN MAGANG KEMENRISTEKDIKTI TAHUN ANGKATAN 2017

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70522/jad.v3i2.22

Abstract

South Lampung Regency is the second largest cocoa bean producer in Lampung Province. This natural resource is very abundant, one of which is in Tarahan Village, South Lampung, but until now it has not been optimally processed and is only sold in the form of dry brown beans which have low selling value. This is because the villagers does not know how to process cocoa beans into cocoa products. Therefore, this service program aims to assist the target community in processing cocoa beans into ready-to-sell products (jam and mask) to improve people welfare. This activity consisted of providing material and training in making jam and chocolate masks for 1 day. After the training, the villagers were able to understand and practice making the chocolate jam and mask. This program is expected to increase chocholate selling value as local regional commodities.
Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

Abstract

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.
Uji Aktivitas Hepatoprotektor Tablet Curcuma® terhadap Kadar SGPT dan SGOT pada Tikus yang Diinduksi Isoniazid Simanullang, Gayatri; Nabila, Novrilia Atika; Rahayyu, Annisa Maulidia; Wardani, Intan Kusuma; Hammami, Akmal
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.848

Abstract

Isoniazid (INH) merupakan obat anti tuberkulosis yang penggunaannya dapat menimbulkan efek samping berupa hepatotoksisitas. Kondisi ini dapat dipantau melalui peningkatan kadar enzim hati, yaitu serum glutamic pyruvic transaminase (SGPT) dan serum glutamic oxaloacetic transaminase (SGOT). Oleh karena itu, diperlukan suatu agen pelindung untuk meminimalisir efek samping hepatotoksik yang ditimbulkan. Temulawak (Curcuma xanthorrhiza Roxb.) dikenal memiliki aktivitas hepatoprotektor yang berpotensi melindungi hati dari kerusakan. Berdasarkan hal tersebut, penelitian ini bertujuan untuk mengetahui pengaruh pemberian sediaan tablet Curcuma® terhadap kadar SGPT dan SGOT pada tikus putih jantan yang diinduksi INH, serta menganalisis korelasi antara dosis Curcuma® dengan penurunan kadar kedua enzim hati tersebut. Metode pada penelitian ini yaitu menggunakan hewan uji berupa tikus putih jantan yang dibagi menjadi tiga kelompok dengan pemberian dosis INH yang sama: kelompok 1 diberikan INH 5,4 mg/kgBB, kelompok 2 curcuma® 0,36 mg/kgBB + INH, dan kelompok 3 curcuma® 0,72 mg/kgBB + INH. Perlakuan diberikan selama 14 hari secara oral untuk diukur kadar SGPT dan SGOT, rasio berat hati, serta pengamatan makroskopis hati. Hasil penelitian menunjukkan bahwa pemberian curcuma® memberikan efek yang berbeda pada kelompok 2 dan 3. Pada kelompok 3, kadar SGPT dan SGOT mengalami penurunan. Sedangkan, pada kelompok 2 hanya kadar SGPT yang menurun, untuk kadar SGOT mengalami peningkatan. Meskipun demikian, perbedaan penurunan kadar SGPT dan SGOT antara kedua kelompok tidak terdapat perbedaan yang signifikan secara statistik (p > 0,05). Rasio hati pada kelompok 1 (3,16%), kelompok 2 (2,83%), dan kelompok 3 (2,71%). Rasio hati pada kelompok 3 menunjukkan persentase yang lebih rendah dibandingkan kelompok perlakuan lainnya. Secara makroskopis, hati pada kelompok 3 memiliki warna segar, licin, dan kenyal, mendekati kondisi hati normal. Pemberian sediaan tablet curcuma® mampu melindungi hati dari kerusakan karena memiliki potensi sebagai hepatoprotektor terhadap tikus putih jantan yang diinduksi isoniazid.
Co-Authors Akhmad, Atika Dalili Hammami, Akmal Hidayaturahmah, Rizky intan kusuma wardani Karim, Miska Aulia Rahayyu, Annisa Maulidia Rooswita, Putri Amelia Simanullang, Gayatri Tantri Liris Nareswari Winni Nur Auli