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Evaluasi Penggunaan Obat Anti Hipertensi Pada Pasien Stroke Iskemik Di Rsud Arifin Achmad Tahun 2022 Nawwar Irfan; Nursyafni; Ayu Rahmawati; Mestika, Diani
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Antihypertensive drugs are one of the drugs most commonly given to ischemic stroke patients. Ischemic stroke is a stroke resulting from thrombosis or embolism that occurs in the cerebral blood vessels and causes obstruction of cerebral blood flow to the cerebral blood vessels. The use of drugs is rational if the patient receives treatment according to his clinical needs. The aim of this study was to determine the appropriate use of antihypertensive drugs in ischemic stroke patients based on the right indication, selection of the right drug, right dose and determine the relationship between sociodemographics and the results of antihypertensive treatment in ischemic stroke patients at Arifin Achmad Regional Hospital. The method used in this research is a descriptive observational method using retrospective data which was carried out by recording medical record data of patients with a final diagnosis of ischemic stroke accompanied by hypertension with a sample size of 80 patients. people (52.5%), 45-64 years old 44 people (55%), working patients 53 people (66.3%), and the most widely used drug class was amlodipine as many as 67 people (56.8%). In the results of the chi-square test with a significance value of p value = 0.05 for the relationship between age and gender on risk factors, the age value was p = 0.004, while the gender value was p = 0.014. It was concluded that the evaluation of the use of antihypertensive drugs at Arifin Achmad Hospital was 100% correct and showed that age and risk factors were related, and gender and risk factors were related. Keywords: Hypertension, ischemic stroke, evaluation of drug use

Evaluasi Penggunaan Obat Dispepsia Pada Pasien Rawat Jalan Periode Juni-November 2022 Di RSUD Rokan Hulu Nursyafni; Tri Nova Lovena; Ulfha, Ulfha Ikhwani
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Dyspepsia is a feeling of discomfort originating from the upper abdomen. The purpose of this study was to evaluate the accuracy of drug use in patients with dyspepsia and the relationship between sociodemographic characteristics, especially age and sex, and risk factors at Rokan Hulu Hospital for the period June–November 2022. This study used a non-experimental descriptive method. Samples were taken from as many as 110 patients. The results showed that the most common patient characteristics were female sex by 66.4% (73 people), the elderly-late age group of 56 years by 30.9% (34 people), patients who did not work by 66.4% (73 people), the drug that was widely used was lansopazole by 48.7% (95 prescriptions), and the class of drug that was widely used was the proton pump inhibitor group by 48.7% (95 prescriptions). On the results of the chi-square test with a significance value of p = 0.05 for the relationship between age, gender, and risk factors, the age value is p = 0.025, while gender is p = 0.000. It was concluded that at Rokan Hulu Hospital, the evaluation of dyspepsia drugs was 100% correct and showed that there was a relationship between age, gender, and risk factors for work. Further research is expected to take observation locations in two or more places as a comparison for more varied results.

Evaluasi Penggunaan Obat Antituberkulosis (OAT) Pada Pasien Tuberkulosis (TB) Di RSUD Arifin Achmad Provinsi Riau Periode Januari – Oktober 2022 Nursyafni; Nurbaiti; Nur Anisa
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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A study has been conducted regarding the evaluation of the use of antituberculosis drugs (OAT) in pulmonary tuberculosis (TB) patients at Arifin Achmad Hospital in Riau Province during the period January–October 2022. This study aims to determine patterns of use of anti-tuberculosis drugs (OAT), evaluate errors in the use of anti-tuberculosis drugs based on The 2016 National Tuberculosis Control Guidelines from the Indonesian Ministry of Health, and test the relationship between treatment outcomes and gender, age, and length of treatment. This research is descriptive in nature, with data collection conducted retrospectively. The results of the study showed that 94.3% of the patients at the hospital were given KDT-type OAT (fixed-dose combination), while for recovery, it reached 71.7%. Based on compliance with the 2016 National TB Control Guidelines standards for indications, dosage, and drug selection, it is 100% balanced. Analysis of the relationship between several factors on treatment outcomes concluded that the factors Gender (p = 0.014; p 0.05) and Age (p = 0.183) both had no significant relationship to patient treatment outcomes. While the length of treatment (p = 0.000; p 0.05) had a significant relationship to patient treatment outcomes.

Potensi Aktivitas Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) sebagai Antihiperurisemia pada Mencit Putih (Mus musculus) Lusi Indriani; Ayu Rahmawati; Nursyafni; Nawwar Irfan; Novita Sari
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Hyperuricemia is a condition where uric acid production increases or the kidneys cannot remove uric acid from the body so that uric acid levels in the blood exceed 7.0 mg/dL in men and 6.0 mg/dL in women. One of the secondary metabolites that have the potential to act as anti-hyperuricemia is flavonoids. Red shoots contain flavonoids, alkaloids, terpenoids, chalcones, and tannins. This study aimed to determine the anti-hyperuricemia activity of ethanol extract of red shoots (Syzygium myrtifolium Walp.) in white mice. This study used 16 male white mice which were randomly divided into 4 treatment groups. Group 1 was negative control (Na-CMC 0.5%), group 2 was positive control (allopurinol 300 mg/KgBW), group 3 was dose 1 (pucuk merah ethanol extract 10 mg/kgBW), and group 4 was dose 2 (pucuk merah ethanol extract 15 mg/KgBW). Before giving treatment, mice were first induced with KBrO3 at a dose of 148 mg/KgBW intraperitoneally and initial uric acid levels were measured. Then each group was given oral treatment. Uric acid levels were measured at 30, 60, and 90 minutes. The results showed that the pucuk merah ethanol extract 15 mg/KgBW (dose 2) had an anti-hyperuricemia activity of 62.42% compared to allopurinol 65.80%.

Aktivitas Analgesik Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) pada Mencit Putih Jantan (Mus musculus) Lusi Indriani; Tri Nova Lovena; Nursyafni; Nawwar Irfan; Alfahtiah Zurlina
The Journal Of Pharmacy Vol. 1 No. 2 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Analgesics are substances that reduce or eliminate pain without causing loss of consciousness. Traditional medicines are considered safer than synthetic drugs. One plant with potential as an analgesic is the red shoot plant (Syzygium myrtifolium Walp). This plant contains flavonoids, anthocyanins, phenolics, and triterpenoids. This study aimed to determine the analgesic activity of ethanol extract of red shoot leaves (EPM) in male white mice. The analgesic effect was obtained through the writhing test using 1% glacial acetic acid induction. Twenty male white mice were divided into 5 treatment groups, including negative control (0.5% Na CMC), treatment 1 (EPM 3.7 mg/kgBW), treatment 2 (EPM 7.4 mg/kgBW), and treatment 3 (EPM 14.8 mg/kgBW), and positive control (mefenamic acid 500 mg/70 kgBW). All mice were given treatment according to their respective groups. After 30 minutes, all mice were induced with 1% glacial acetic acid at a dose of 10 ml/kgBW intraperitoneally. Then, the number of writhes was observed every 5 minutes for 60 minutes. The average number of writhes data was analyzed using ANOVA and Tukey HSD tests. The results showed that treatment groups 2 (7.40 mg/kgBW) and 3 (14.80 mg/kgBW) showed analgesic activity in male white mice induced by 1% acetic acid. The best dose was 14.80 mg/kgBW with writhing protection of 34.74% and analgesic efficacy of 45.59% compared to mefenamic acid.

Pengujian Konsentrasi Hambat Minimum Ekstrak Daun Mangrove (Avicennia alba Blume) Terhadap Shigella sonnei Nursyafni; Rahmawati, Ayu; Nurbaiti; Irfan, Nawwar; Nabilla, Alivia
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Infectious diseases are a public health problem for both developed and developing countries. The cause of an infectious disease such as in Shigella sonnei bacteria which occurs in dysentery is characterized by feces mixed with blood and mucus usually accompanied by fever. One solution to overcome dysentery is by utilizing plants that can be processed into medicine. One of them is mangrove (Avicennia alba Blume) which contains phytochemical compounds as antibacterial activity. This study is an experimental study that aims to determine the minimum inhibitory concentration (MIC) of mangrove leaf ethanol extract (Avicennia alba Blume) against Shigella sonnei bacteria. The minimum inhibitory concentration (MIC) value of the extract was determined using the liquid dilution method and continued with solid dilution, with concentrations of 11%, 12%, 13%, 14%, and 15%. Observations were made to see whether bacterial growth in the media. The test results showed that mangrove leaf ethanol extract (Avicennia alba Blume) had a minimum inhibitory concentration at a concentration of 15% in inhibiting the growth of Shigella sonnei bacteria with clear around the media.

Tingkat Pengetahuan Dan Perilaku Swamedikasi Penggunaan Obat Bebas Pada Masyarakat Di Kecamatan Simpang Kanan Kabupaten Rokan Hilir Ayu Rahmawati; Nursyafni; Novtafia Endri; Muhammad Arif; Nawwar Irfan; Wulandari, Tri Ayu; Fitratul Wahyuni
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Self-medication is an act of self-medication carried out by the community to maintain health or manage disease based on personal diagnosis, using drugs repeatedly. This study aims to analyze the relationship between knowledge level and self-medication behavior using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency. The research was conducted observational with a cross-sectional approach, using quota sampling technique and questionnaires as instruments. The results showed that out of 90 respondents, 77.8% had good knowledge, 21.1% had sufficient knowledge, and 1.1% had poor knowledge. In terms of behavior, 81.1% had good behavior, while 18.9% had moderate behavior in self-medication. Analysis using the Chi-Square test resulted in a p-value of 0.002 (p<0.05), indicating a significant relationship between the level of knowledge and behavior of self-medication using over-the-counter drugs in the community in Simpang Kanan District, Rokan Hilir Regency.

Uji Aktivitas Antioksidan Ekstrak Etanol 70% Daun Pandan Wangi (Pandanus amaryllifolius Roxb) Dengan Metode DPPH Muhammad Arif; Ayu Rahmawati; Noveri Rahmawati; Nursyafni; Indah, Indah Kurniawati
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Antioxidants and free radicals are topics that are increasingly discussed in the field of health and lifestyle. Free radicals, which result from oxidative stress, are known to play a role in the development of many serious diseases, such as cancer, cardiovascular disorders and premature aging. Antioxidants are able to neutralize free radicals, thus having the potential to prevent or reduce the impact of these diseases. This study aims to evaluate the antioxidant activity of ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb) using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and determine the IC50 value as an indicator of effectiveness. Experimental methods were used to analyze antioxidant activity, with DPPH assays performed using a UV-Vis spectrophotometer. The results showed that the ethanol extract of pandan leaves had an IC50 value of 180.21 µg/mL, which was slightly lower than vitamin C as a positive control with an IC50 value of 136.03 µg/mL. Nevertheless, the antioxidant activity of pandan leaf extract is still in the moderate category, indicating its potential as a source of natural antioxidants. This study also emphasizes the importance of technical factors, such as temperature, incubation duration, and solvent quality, in influencing the test results. This study opens up opportunities for further development in the optimization of extraction and utilization of pandan wangi leaves as a natural ingredient to fight oxidative stress.

Hubungan Tingkat Pengetahuan, Sikap Siswa SMAN Se- Kota Pekanbaru Terhadap Praktik Penggunaan Obat Analgetik Yang Dijual Bebas Di Pasaran Ayu Rahmawati; Nursyafni; Nurhasanah; Efilia Meirita
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Analgesics are drugs that are often used to relieve pain without affecting a person's consciousness. This study aims to determine the relationship between the level of knowledge, attitudes of SMAN students in Pekanbaru City towards the practice of using analgesic drugs sold over the counter on the market. This study uses a descriptive survey method with a sampling technique, namely the simple random sampling technique using a questionnaire instrument. Where there were 367 respondents involved in this study, dominated by 204 females and 163 male respondents. The age range is 15-18 years, the majority of whom are 16 years old. Data analysis using bivariate using chi square test and multivariate using F test. The results showed that the level ofknowledge was sufficient 251 respondents (68.4%), positive attitude 311 (84.7%) and lack of practice as many as 276 (75.2%). In bivariate analysis there was a significant relationship between knowledge of the practice of using analgesic drugs with (p value = 0.000 <0.05). There was no significant relationship between attitudes towards the practice of using analgesic drugs with (p value = 0.0716 > 0.05). This study emphasizes the importance of education about the use of analgesic drugs among high school students to prevent drug abuse

Evaluasi Tingkat Pengetahuan dan Perilaku Terhadap Penggunaan dan Resistensi Antibiotik Di Kalangan Mahasiswa Farmasi Universitas Muhammadiyah Riau Nursyafni; Ayu Rahmawati; Shakynna Suandha
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Antibiotik adalah obat yang digunakan untuk mencegah dan mengobati infeksi bakteri, yang merupakan salah satu jenis obat yang paling umum dan banyak digunakan di masyarakat. Penelitian ini bertujuan untuk mengidentifikasi distribusi karakteristik responden dan hubungan antara ingkat pengetahuan serta perilaku terhadap penggunaan antibiotik di kalangan mahasiswa farmasi Universitas Muhammadiyah Riau. Sampel penelitian terdiri dari 86 orang yang didominasi oleh perempuan (87,2%), sementara laki-laki hanya berjumlah 12,8%. Rentang usia responden berkisar antara 18 hingga 22 tahun, dengan mayoritas berada pada usia 19 dan 21 tahun, yang bersama-sama mencakup 59,3% dari total sampel. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat pengetahuan yang baik mengenai penggunaan antibiotik, dengan 94,2% responden berada dalam kategori ini. Selain itu, perilaku penggunaan antibiotik di kalangan responden juga tergolong baik, dengan 100% responden menunjukkan perilaku yang positif. Analisis statistik lebih lanjut mengungkapkan adanya hubungan yang signifikan antara tingkat pengetahuan dan perilaku penggunaan antibiotik, dengan nilai p sebesar 0,000 (p<0,05). Hasil ini menunjukkan bahwa tingkat pengetahuan yang lebih tinggi berkorelasi positif dengan perilaku yang lebih baik dalam penggunaan antibiotik. Temuan ini menggarisbawahi pentingnya pendidikan yang memadai dalam meningkatkan pengetahuan tentang penggunaan antibiotik yang tepat, yang pada gilirannya dapat mempengaruhi perilaku penggunaan yang lebih bertanggung jawab di kalangan mahasiswa.

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