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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Heart Science Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Hendry Purnasidha Bagaswoto
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada – Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The IndONEsia ICCU Registry Juzar, Dafsah Arifa; Bagaswoto, Hendry Purnasidha; Muzakkir, Akhtar Fajar; Habib, Faisal; Astiawati, Tri; Prasetya, Indra; Wirawan, Hendy; Ilhami, Yose Ramda; Djafar, Dewi Utari; Sungkar, Safir; Danny, Siska Suridanda
Jurnal Kardiologi Indonesia Vol 44 No 4 (2023): Indonesian Journal of Cardiology: October - December 2023
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1603

Abstract

Introduction: Patients in the Intensive Cardiovascular Care Unit (ICCU) often present with cardiovascular disease (CVD) issues accompanied by various non-cardiovascular conditions. However, a widely applicable scoring system to predict patient outcomes in the ICCU is lacking. Therefore, developing and validating scores for predicting ICCU patient outcomes are warranted. The aims of the IndONEsia ICCU (One ICCU) registry include developing an epidemiological registry of ICCU patients and establishing a multicentre research network to analyse patient outcomes. Methods and results: This nationwide multicenter cohort protocol will capture data from patients receiving cardiovascular critical care treatment in 10 Indonesian hospitals with ICCU facilities. Recorded data will encompass demographic characteristics, physical examination findings at hospital and ICCU admission, diagnoses at ICCU admission, therapy, intervention, complications on days 3 and 5 of in-ICCU care, in-hospital outcomes, and 30-day outcomes. Conclusion: The One ICCU is a large, prospective registry describing the care process and advancing clinical knowledge in ICCU patients. It will serve as an investigational platform for predicting the mortality of ICCU patients.
Impact of multivessel coronary artery disease on early and late clinical outcome in ST-Segment elevation myocardial infarction patients who underwent percutaneous coronary intervention: insight from Indonesia Damarkusuma, Arditya; Taufiq, Nahar; Bagaswoto, Hendry Purnasidha; Saputra, Firandi; Sukmadja, Daniel; Setianto, Budi Yuli
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.12536

Abstract

It is estimated that 15 people for every 1000 Indonesian residents suffer from cardiovascular disease (CVD) including ST-segment elevation myocardial infarction (STEMI). Percutaneous coronary intervention (PCI) is often performed in patients with STEMI. Several factors affect clinical outcome after PCI procedure including multivessel coronary artery disease. This study aimed to measure the impact of multivessel coronary artery disease on the early and late outcomes of STEMI patients undergoing PCI procedures. This was a prospective cohort study on STEMI patients undergoing PCI procedures from the period of August to December 2021. Two expected cohorts were performed i.e. patients who suffered from single-vessel disease (SVD) and patients who suffered from multivessel disease (MVD). Forty six patients with STEMI were enrolled in this study consisting of 24 (52.17%) patients with MVD and 22 (47.83%) patients with SVD. No significant difference in baseline characteristics between MVD and SVD groups was observed (p > 0.05). The MVD group (91.67%) used a more radial percutaneous approach compared with the SVD group (54.55%; p = 0.04). In addition, no significant difference between the SVD group and the MVD group in major adverse cardiovascular events (MACE) and echocardiographic outcome after 90-d follow up was observed (p > 0.05). In conclusion, MVD has similar impacts on early and late clinical outcomes compared with SVD in STEMI patients undergoing PCI procedures.
The effect of infection on mortality in acute coronary syndrome patients at Dr. Sardjito General Hospital, Yogyakarta Putri, Naila Vinidya; Anggrahini, Dyah Wulan; Bagaswoto, Hendry Purnasidha
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13445

Abstract

Ischemic heart disease is the second most significant health burden in Indonesia and the world. The prevalence of coronary heart disease patients in Yogyakarta is predicted to experience a continuous increase. In Sardjito Hospital, mortality rate of acute coronary syndrome (ACS) patients reaches 15%, with pneumonia infection identified as one of the predictors. Despite this high mortality rate, there is a lack of studies addressing the contribution of infectious comorbidities to mortality incidence among ACS patients. This study aimed to investigate the e ffect of infectious comorbidities on the incidence of mortality among ACS patients and its mortality rate in Sardjito Hospital. This study used a cross-sectional design in 794 patients diagnosed with ACS and registered in the SCIENCE registry from January to December 2022 at Sardjito Hospital. The analysis was conducted using the Chi-square method to determine the effect of infectious comorbidities on mortality among ACS patients and a logistic regression test to evaluate the correlation between variables. Based on bivariate analysis, it was found that infectious comorbidities increased mortality rate among ACS patients (p<0.001, OR=2.22[1.46-3.38]), reaching 5.2%. The bivariate analysis between confounding factors and outcome of patients showed that obesity, dyslipidemia, and revascularization significantly influenced the results of ACS patients. Based on multivariate analysis, it was discovered that infectious comorbidities, obesity, diabetes, dyslipidemia, and revascularization had a significant association with mortality of patients with ACS. Furthermore, infectious comorbidities increased the odds of mortality for ACS patients by 2.04 times. Infectious comorbidities increased the incidence of mortality in ACS patients by 2.04 times with mortality rate of 5.2%.
The effect of invasive strategy versus conservative strategy on mortality in patients with non-ST-elevation myocardial infarction at Sardjito Hospital Yogyakarta Pradhana, Aditya; Bagaswoto, Hendry Purnasidha; Saputra, Firandi; Setianto, Budi Yuli
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.14

Abstract

BACKGROUND: Acute myocardial infarction (AMI) causes high hospital admission rates and mortality in Indonesia. Previous studies showed that invasive strategies on non-ST-elevation myocardial infarction (NSTEMI) patients can provide more benefit in clinical outcomes, particularly in high- and very high-risk groups. However, this strategy cannot be implemented due to transportation limitations or a lack of available catheterization facilities in some regions. Recent meta-analyses suggested that early invasive strategies (≤24 hours), delayed strategies (>24 hours), or conservative showed no differences significantly in mortality rates from any cause, stroke or cardiovascular death in NSTEMI patients. OBJECTIVES: This study aims to define the impact of invasive strategies on in-hospital mortality in high and very high-risk NSTEMI patients at Sardjito Hospital. METHODS: A retrospective cohort study utilized data from 326 NSTEMI patients who satisfied the inclusion and exclusion criteria, obtained from the Sardjito Cardiovascular Intensive Care (SCIENCE) registry between January 2023 and June 2024. RESULTS: The invasive and conservative method groups did not substantially differ in in-hospital mortality among NSTEMI patients in either unadjusted (p=0.09) or adjusted analysis (p=0.071, OR 2.251, 95% CI [0.932–5.434]). However, a significant difference was found in the high-risk group (p=0.042) but not in the very-high-risk group (p=0.525). Multivariate analysis confirmed Killip classification (p=0.000, OR 4.449, 95% CI [2.195–9.016]) and hs-Troponin T levels (p=0.006, OR 1.000, 95% CI [1.000–1.000]) as independent mortality predictors. CONCLUSION: Invasive management gave high-risk NSTEMI patients a survival advantage over conservative therapy at Sardjito Hospital, but not in the very-high-risk population.
Effect of reperfusion time on right ventricular remodeling in inferior ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention Probokusumo, Jagaddhito; Mumpuni, Hasanah; Sanggula, Pratiwi Noor Purnama Putri Sanggula; Bagaswoto, Hendry Purnasidha
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art7

Abstract

Background: Right ventricle (RV) remodeling and dysfunction are frequent in inferior ST-elevation myocardial infarction (STEMI) patients and possibly implicated to poor outcomes. Objective: The purpose of this study is to investigate the influence of reperfusion time on RV remodeling in patients with inferior STEMI who had primary percutaneous coronary intervention (PPCI).Methods: The subjects were patients with inferior STEMI who had undergone PPCI and met the inclusion and exclusion criteria. From September 2021 to April 2022, samples were taken in the order in which they arrived at the Dr. Sardjito Hospital in Yogyakarta, Indonesia. To investigate the occurrence of RV remodeling, 2D-transthoracic echocardiography was performed before PPCI as baseline and 3-months after PPCI. Confounding factors were investigated using bivariate and multivariate analysis.Results: The RV remodeling was observed in 12 (28.6%) of 42 inferior STEMI patients undergoing PPCI. The RV remodeling group had a longer median reperfusion time (798.5 vs 710 minutes, p=0.568). The baseline RV end-systolic area (RVESA) and RV end-diastolic area (RVEDA) had significant correlations with the occurrence of RV remodeling (p=0.046; p=0.008, respectively). The tricuspid annular plane systolic excursion (TAPSE) rose considerably in both groups during the 3-month follow up. There were significant variations in RVEDA and RV basal diameter in the RV remodeling group, but there was a substantial rise in fractional area change (FAC) and RVESA in the non-RV remodeling group.Conclusion: In patients with inferior STEMI undergoing PPCI, reperfusion time showed no significant effect on RV remodeling.
Management of Decongestion in Acute Heart Failure: Time for a New Approach? Pramudyo, Miftah; Putra, Iwan Cahyo Santosa; Zulkarnain, Edrian; Danny, Siska Suridanda; Bagaswoto, Hendry Purnasidha; Anjarwani, Setyasih; Mazwar, Irmaliyas; Juzar, Dafsah Arifa; Pratama, Vireza; Habib, Faisal; Ispar, Akhtar Fajar Muzakkir Ali; Widyantoro, Bambang
Jurnal Kardiologi Indonesia Vol 43 No 2 (2022): Indonesian Journal of Cardiology: April - June 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1381

Abstract

As the primary cause of hospitalization in acute heart failure (AHF) patients, congestion was responsible for a higher risk of mortality, rehospitalization, and renal dysfunction in AHF patients. Although loop diuretic was routinely used as the mainstay of AHF therapy, it is still ineffective to obtain the euvolemic state in most hospitalized AHF patients. Therefore, a higher loop diuretic dose was often required to increase the decongestion effect. However, consequently, it can cause several detrimental complications, including renal dysfunction, neurohormonal activation, hyponatremia, hypokalaemia, and reduced blood pressure, which eventually result in poor prognosis. Hence, the new approach may be proposed to optimize decongestion in acute phase, including the use of arginine vasopressin V2 receptor antagonist – Tolvaptan. As an additive therapy to loop diuretic in AHF patients, it can be considered due to its several beneficial effects, including greater decongestion effect, lowered worsening renal function incidence, counteract neurohormonal activation, neutralized hyponatraemic state, no alteration of potassium metabolism, stabilize the blood pressure, and reduced requirement of a higher dose of loop diuretic to achieve an equal or even greater decongestion effect compared to a high dose of loop diuretic alone. Tolvaptan provided favourable outcomes in several specific populations and was considered safe with several mild adverse effects. Several guidelines across countries have approved the use of Tolvaptan in AHF patients with or without hyponatremia. The initial dose of Tolvaptan was 7.5 to 15 mg and can be titrated up to 30 mg. However, further studies were still required to determine the timing dose and optimal dose of Tolvaptan in general and elderly populations with AHF, respectively.This article has a related Erratum.
Simplified Selvester QRS Score as an Infarct Size Parameter in STEMI Patients Undergoing Pharmacoinvasive or Primary Percutaneous Coronary Intervention Prasetya, Arif Eka; Hartopo, Anggoro Budi; Taufiq, Nahar; Bagaswoto, Hendry Purnasidha; Setianto, Budi Yuli
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2008

Abstract

In “Simplified Selvester QRS Score as an Infarct Size Parameter in STEMI Patients Undergoing Pharmacoinvasive or Primary Percutaneous Coronary Intervention” (Indonesian Journal of Cardiology, 43(4), 150-8. https://doi.org/10.30701/ijc.1186), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1186. The error occurs only in the PDF; the DOI listed in the article metadata is already correct. The publisher apologizes for any inconvenience caused by this error.
A Rare Case of Ventricular Standstill and High-Grade AV Block in Patient with Thyrotoxicosis Aryaputra, Achmad Bima; Bagaswoto, Hendry Purnasidha
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2010

Abstract

In “A Rare Case of Ventricular Standstill and High-Grade AV Block in Patient with Thyrotoxicosis” (Indonesian Journal of Cardiology, 43(4), 159-67. https://doi.org/10.30701/ijc.1299), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1299. The error occurs only in the PDF; the DOI listed in the article metadata is already correct.The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.1299
Predictors of Acute Kidney Injury in Critically Ill Patient at Intensive Cardiac Care Unit Jauhari, Haris; Bagaswoto, Hendry Purnasidha; Setianto, Budi Yuli
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2028

Abstract

In “Predictors of Acute Kidney Injury in Critically Ill Patient at Intensive Cardiac Care Unit” (Indonesian Journal of Cardiology, 43(4), 144-9. https://doi.org/10.30701/ijc.1322), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1322. The error occurs only in the PDF; the DOI listed in the article metadata is already correct.The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.1322
Co-Authors Anggoro Budi Hartopo Anjarwani, Setyasih Aryaputra, Achmad Bima Astiawati, Tri Bambang Widyantoro Budi Yuli Setianto Damarkusuma, Arditya Daniel Daniel Dewi Utari Djafar, Dewi Utari Dyah Wulan Anggrahini Erika Maharani Erika Maharani Ferdinandus Bayu Satria Firandi Saputra Firandi Saputra, Firandi Habib, Faisal Hani Khairina Hasanah Mumpuni Ilhami, Yose Ramda Indra Prasetya Ispar, Akhtar Fajar Muzakkir Ali Jauhari, Haris Juzar, Dafsah Arifa Krisdinarti, Lucia Lucia Krisdinarti Mazwar, Irmaliyas Muzakkir, Akhtar Fajar Nahar Taufik Nahar Taufiq, Nahar Pradhana, Aditya Pramudyo, Miftah Prasetia, Arif Eka Prasetya, Arif Eka Pratama, Vireza Probokusumo, Jagaddhito Putra, Iwan Cahyo Santosa Putri, Naila Vinidya Rendi Asmara Sanggula, Pratiwi Noor Purnama Putri Sanggula Siska Suridanda Danny Sukmadja, Daniel Sungkar, Safir Wirawan, Hendy Zulkarnain, Edrian