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All Journal Medical Journal of Indonesia Jurnal Bidang Ilmu Kesehatan
Canintika, Anissa Feby
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Adipose-derived mesenchymal stem cells enhance regeneration in a chronic peripheral sciatic nerve injury Sprague-Dawley rat model Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257780

Abstract

BACKGROUND Obtaining optimal functional outcomes in patients with chronic peripheral nerve injuries (PNIs) remains challenging due to the limited regeneration of the neuromuscular junction (NMJ). Adipose-derived mesenchymal stem cells (AD-MSCs) can differentiate into Schwann-like cells, secrete neurotrophic factors, and recruit native Schwann cells. This study aimed to analyze the effects of AD-MSCs on functional outcomes in a chronic PNI model. METHODS An in vivo study was performed using 20 male Sprague-Dawley rats with chronic PNI of the right sciatic nerve. Rats were divided into two groups: the AD-MSC group (n = 10), receiving human AD-MSC injections in the NMJ; and the control group (n = 10), receiving normal saline injections. Walking track analysis and electrophysiological assessments were performed 8 weeks after the nerve repair. Postmortem gastrocnemius muscle weights and immunohistochemical examinations were also performed. RESULTS The AD-MSCs showed significantly larger fiber diameters than the control group (45.54 [13.1] versus 35.46 [6.64]; p = 0.011). While clinical, electrophysiological, and gastrocnemius muscle weight data suggested a trend toward improved outcomes in the AD-MSCs group, the differences were not statistically significant. CONCLUSIONS AD-MSC implantation may enhance nerve regeneration, as demonstrated by a better outcome profile in the AD-MSCs group.
Optimal time point for evaluation in a chronic peripheral nerve injury rat model: a preclinical study Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257778

Abstract

BACKGROUND Peripheral nerve injury (PNI) can cause severe functional disabilities and progresses dynamically over time. Since evaluations held at different time points will yield different results, finding an optimal model for PNI comparison is needed. This study aimed to create an animal model of chronic denervation that simulates the progress of nerve injury. METHODS 6 male Sprague-Dawley rats underwent complete sciatic nerve transection in their right hind limbs, with severed nerve ends secured to a nearby muscle to prevent nerve regrowth. The rats were sacrificed at 2, 3, and 4 weeks. The assessment included walking analysis (pre- and post-injury), wet muscle weight measurement, and histological examination. RESULTS Progressive gastrocnemius muscle degeneration was observed at 3 different time points. Minimal degenerative changes were noted at 2 weeks, while extensive fibrosis (83.25 [12.19]% collagen area) appeared in the 4th week. The 3rd-week samples showed lymphocyte infiltrations, muscular atrophy, and progressive fibrosis, making it the best model for chronic PNI. CONCLUSIONS A 3-week chronic denervation model is proposed as a long-term PNI for further regenerative research.
Berkah ke Meja Kerja: Implementasi Nilai Aswaja dalam Profesionalisme Kantor Fatkhullah, Faiz Karim; Canintika, Anissa Feby; Kembaren, Jefry Sondang; Hermansyah, Nerissa Arviana Koesuma
JURNAL BIDANG ILMU KESEHATAN Vol 16, No 1 (2026): Jurnal Bidang Ilmu Kesehatan
Publisher : Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/jbik.v16i1.7809

Abstract

Rapid social and professional developments often create a gap between spiritual life and daily workplace practices, which can lead to the marginalization of religious values within professional environments. In Islamic teachings, work is not only viewed as a means of fulfilling material needs but can also be considered an act of worship when it is carried out with sincere intentions and guided by ethical principles. This article aims to examine the implementation of Ahlussunnah wal Jama’ah (Aswaja) values in fostering professionalism in office-based work settings. The study employs a literature review method by analyzing relevant academic sources discussing the core principles of Aswaja, including tasamuh (tolerance), tawazun (balance), tawasuth (moderation), i’tidal (justice), and amar ma’ruf nahi munkar (promoting good and preventing wrongdoing). The findings indicate that Aswaja values extend beyond ritual religious practices and function as a comprehensive ethical framework applicable to professional life. Tasamuh encourages mutual respect and inclusivity in the workplace, while tawazun emphasizes the importance of balancing worldly responsibilities with spiritual obligations. Furthermore, tawasuth guides moderate and balanced decision-making, and i’tidal reinforces fairness and integrity in professional conduct. Amar ma’ruf nahi munkar also serves as a moral foundation for maintaining ethical behavior and preventing misconduct. Integrating these values can help professionals develop responsible, ethical, and inclusive work attitudes, leading to success that encompasses not only material achievement but also moral integrity and spiritual well-being
Co-Authors Achmad Fauzi Kamal Aprilya, Dina Aria Kekalih Fatkhullah, Faiz Karim Fitri Octaviana Heri Suroto Hermansyah, Nerissa Arviana Koesuma Ismail Hadisoebroto Dilogo Kembaren, Jefry Sondang Nurjati Chairani Siregar Puspita Eka Wuyung Radiana Dhewayani Antarianto Wahyu Widodo