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Wulansari, Arfiana Tanti
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Phytochemicals, Bioactivity, and Utilization of Etlingera elatior as a Medicinal Plant Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.3977

Abstract

Etlingera elatior, commonly known as torch ginger, is a plant widely used as a cooking spice. Native to Southeast Asia, E. elatior is not only valued for its culinary uses but also for its high nutritional content. It is also used medicinally, including as a treatment for typhoid fever and various other diseases. The bioactivity of this plant has been extensively studied. It has antioxidant, antibacterial, antifungal, tyrosinase-inhibiting, cytotoxic, and hepatoprotective properties. E. elatior acts as an antimicrobial, antioxidant, anticancer, anti-hyperglycemic, anti-hyperuricemia, anti-inflammatory, larvicidal, skin-whitening, anti-aging, and wound-healing agent. These biological activities are attributed to its rich content of phytochemical compounds, including phenols, flavonoids, glycosides, saponins, tannins, steroids, and terpenoids. Given its wide range of biological activities and chemical compounds, E. elatior warrants further research to contribute to the development of natural medicinal plants in Indonesia.
Exploring the Phytochemistry and Pharmacological Potentials of Annona squamosa L. : A Systematic Review of Traditional Uses and Modern Applications Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah; Nurhidayati, Tutik; Trisnawati, Indah; Aprilia, Veranita; Pradani, Anindhita Nabilah; Putra, Roy Ardiansyah; Lekatompessy, Vanela Chatrin
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.4287

Abstract

Annona squamosa L. (Annonaceae) is a tropical evergreen fruit tree with a long history of traditional use across various cultures. Its fruit, known as srikayas, is commonly consumed fresh and used in candies, ice creams, and beverages. Different parts of A. squamosa have been widely applied in ethnomedicine as tonics, apophlegmatisants, coolants, abortifacients, and heart sedatives. Phytochemical studies have identified key bioactive compounds including annonaceous acetogenins (ACGs), diterpenes (DITs), alkaloids (ALKs), and cyclopeptides (CPs), with 33 diterpenes, 19 alkaloids, 88 acetogenins, and 13 cyclopeptides reported up to 2016. Extensive research reveals A. squamosa exhibits diverse pharmacological activities such as anticancer, antioxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidal, and molluscicidal effects. Notably, diterpenes and acetogenins contribute to its potent anticancer properties through apoptosis induction and cell cycle arrest. Leaf and seed extracts demonstrate significant antidiabetic, anti-inflammatory, and hepatoprotective actions, while seed peptides exhibit vasorelaxant and hypotensive effects via calcium channel inhibition. This review integrates phytochemical, ethnopharmacological, and bioactivity data, highlighting the therapeutic potential of A. squamosa and encouraging further clinical studies to validate its medicinal applications.
Phytochemical Constituents and Therapeutic Potential of Pine Bark and Needle Extracts in Cardiovascular and Metabolic Disorders Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah; Nurhidayati, Tutik; Aprilia, Veranita; Pradani, Anindhita Nabilah; Putra, Roy Ardiansyah; Farid, Ardiansyah
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.4288

Abstract

Cardiovascular and metabolic diseases remain leading global health challenges, necessitating novel and complementary therapeutic strategies. Natural plant-derived compounds, particularly from pine bark and needles, have attracted attention for their potential health benefits. This study aims to comprehensively review the phytochemical composition of pine bark and needle extracts, focusing on their biological activities and potential roles in preventing and managing cardiovascular and metabolic disorders. A literature review was conducted using databases such as PubMed, ScienceDirect, and Google Scholar, focusing on studies published from 2000 to 2024. The selection criteria included in vitro, in vivo, and clinical research articles investigating the phytochemical profiles and pharmacological effects of pine bark and needle extracts on cardiovascular and metabolic health. Pine bark and needle extracts, especially from Pinus pinaster, are rich in proanthocyanidins, flavonoids, phenolic acids, stilbenes, and terpenoids. These bioactive compounds exhibit potent antioxidant, anti-inflammatory, and endothelial protective properties. Clinical and preclinical studies demonstrate improvements in blood pressure, lipid profiles, glucose metabolism, and vascular function. Emerging evidence also suggests a role in modulating gut microbiota, contributing to systemic metabolic benefits. Pine bark and needle extracts hold significant promise as adjunct therapies for cardiovascular and metabolic diseases through their multi-targeted mechanisms. Further well-designed clinical trials are necessary to validate their efficacy, optimize dosages, and ensure safety for broader therapeutic application.
Co-Authors Aprilia, Veranita Farid, Ardiansyah Indriani, Ratri Dwi Kristanti Indah Purwani Lekatompessy, Vanela Chatrin Pradani, Anindhita Nabilah Putra, Roy Ardiansyah Rosyid Ridho, Muhammad Ainur Trisnawati, Indah Tutik Nurhidayati