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All Journal CHEMPUBLISH JOURNAL Al-Khidmah Jurnal Pengabdian Masyarakat
Jipasca, Elon
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Religion Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Languange, Linguistic, Communication & Media Social Sciences

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Inovasi Pengembangan Teknologi Sistem Otomatis Pengendalian Hama di Kebun Buah Kelompok Tani Harapan Kota Palangka Raya Arsana, Mu afa; Ngazizah, Febri Nur; Wilda, Robiatul Witari; Adi, Mika; Jipasca, Elon; Febrianto, Yahya; Alfanaar, Rokiy; Rahman, Sudarman; Suprayogi, Thathit; Citrariana, Shesanthi; Fatiqin, Awalul
Al-Khidmah Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2025): SEPTEMBER-DESEMBER
Publisher : Institute for Research and Community Service (LPPM) of the Islamic University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56013/jak.v5i3.4923

Abstract

The Community Service Program was carried out at the Harapan Farmers Group, Kereng Bangkirai Sub-district, Palangka Raya City, as an effort to provide innovative solutions to pest attack problems that often reduced fruit farm productivity. Previously, farmers had relied on manual pesticide spraying, which required considerable time, labor, and cost, and posed health risks. To address this challenge, the service team from the University of Palangka Raya developed an automated pest control system that was able to regulate pesticide spraying independently and efficiently. The activities were conducted through stages of socialization, training, and system mapping of automation in the fruit farm area, involving members of the farmers group actively. The implementation results showed an increase in participants’ understanding of the technology by 30–40 percent, improved efficiency in pesticide use by up to one-third compared to manual methods, and a reduction in working time by nearly 50 percent. This activity not only improved farmers’ skills and productivity but also served as a concrete step toward the implementation of sustainable smart farming in Palangka Raya through collaboration between the university and the community.
Integrative Network Pharmacology and Molecular Docking Analysis of Tinospora crispa L. for Breast Cancer Therapy Dewi, Mirnawati; Ariefin, Mokhamat; Yolan Kalalinggi, Septaria; Andini, Novelia; Jipasca, Elon
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

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Abstract

Breast cancer remains one of the leading mortality causes of disease related to cancer. Therefore, it is necessary to explore novel alternative therapeutic, particularly through the utilization of plant-derived natural product. Tinospora crispa L. contains diverse bioactive compounds with reported antioxidant and anticancer activities. This study integrates network pharmacology and molecular docking approaches to elucidate the molecular mechanisms of T. crispa against breast cancer. A total of 72 overlapping targets were identified between T. crispa compounds and breast cancer-related proteins, forming a highly interconnected PPI network consisting of 72 nodes and 340 edges. Clustering and enrichment analyses revealed that second cluster was significantly associated with cancer-related pathways, including AKT1, MAPK, and EGFR. The compound–protein–pathway network demonstrated two compound from T. crispa, apigenin and cycloeucalenone, possessed the highest degrees, suggesting their central regulatory roles. Molecular docking further confirmed these findings, showing that cycloeucalenone exhibited the strongest binding affinity toward EGFR and AKT1 through extensive hydrophobic interactions, whereas apigenin bound more stably to MAPK3 via multiple hydrogen bonds and hydrophobic interactions. These findings indicate that T. crispa compounds may exert anticancer effects by modulating multiple oncogenic pathways, supporting their potential development as multi-target agents in breast cancer therapy.
Co-Authors Adi, Mika Alfanaar, Rokiy Andini, Novelia Arsana, Mu afa Citrariana, Shesanthi Fatiqin, Awalul Mirnawati Dewi, Mirnawati Mokhamat Ariefin Ngazizah, Febri Nur Rahman, Sudarman Thathit Suprayogi Wilda, Robiatul Witari Yahya Febrianto Yolan Kalalinggi, Septaria