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Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D Rollando, Rollando; Alfanaar, Rokiy
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.886 KB) | DOI: 10.12928/pharmaciana.v7i2.6699

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. 
Penerapan Metode Sonikasi terhadap Adsorpsi Fe(III) pada Zeolit Alam Teraktivasi Rismiarti, Zuri; Yuniati, Yuyun; Alfanaar, Rokiy
ALCHEMY Vol 5, No 2 (2016): ALCHEMY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (468.733 KB) | DOI: 10.18860/al.v5i2.3673

Abstract

Iron (III) (Fe (III)) is widely used in the industry such us water treatment, the sugar cane, the concrete industry and coal mining. Industrial activity using Fe(III) has potential impact to environmental pollution problems due to that industry produces Fe waste that one of hazardous waste. Fe content excess might toxic effect to human health and the environment. Zeolite as adsorbent has been evaluated extensively for Fe and other heavy metal. Sonication method has been widely developed in polymer preparation. The method is more effective in operation time because the reaction rate increased and also more efficient on the usage of chemical reagens. The optimization of reaction time, the ratio of Fe(III) with activated zeolite, the influence of pH, and temperature has been assessed for Fe(III) adsorption with an activated zeolite by sonication technique. The formation of Fe(III)-SCN complex assay was used for determination of Fe(III) adsorbed by the activated zeolite with using spectrophotometer. The results showed a relatively short operation time (15 minutes), at pH of 4, temperature of  30 °C with the ratio of 1:50 (weight/volume) for the activated zeolite and Fe(III). 
Sintesis Senyawa Koordinasi Astaxanthin Dengan Bantuan Gelombang Ultrasonik Rokiy Alfanaar; Dion Notario
Jurnal Kimia dan Kemasan Vol. 41 No. 2 Oktober 2019
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24817/jkk.v41i2.3366

Abstract

Astaxanthin merupakan senyawa turunan karotenoid xantofil yang sangat potensial dalam pengobatan kanker. Salah satu upaya meningkatkan aktivitas anti kanker dari astaxanthin adalah dengan menggabungkan senyawa astaxanthin dengan ion logam. Upaya sintesis senyawa koordinasi astaxanthin dengan ion logam Fe3+, Mn2+, dan Zn2+ telah dilakukan dengan bantuan gelombang ultrasonik. Panjang gelombang maksimal senyawa kompleks Mn(II)-Astaxanthin adalah 473 nm, Fe(III)-Astaxanthin adalah 355 nm, dan Zn(II)-Astaxanthin adalah 473 nm. Hasil FTIR menunjukan munculnya gugus fungsi khas astaxanthin pada semua kompleks dan munculnya serapan pada 535 cm-1, untuk kompleks Mn(II)-Astaxanthin, 397 cm-1 untuk Fe(III)-Astaxanthin, dan 535 cm-1 untuk Zn(II)-Astaxanthin yang mengindikasikan adanya ikatan logam dengan atom donor dari Astaxanthin.
Physical Properties Investigation on Sunscreens with Colloidal Gold and Moringa oleifera Extract Ruth Febriana Kesuma; Eva Monica; Rokiy Alfanaar
The Journal of Pure and Applied Chemistry Research Vol 9, No 1 (2020): Edition January-April 2020
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/jpacr.ub.2020.009.01.464

Abstract

Botanicals were known as active ingredients in sunscreens due to their dermal protecting. Gold in colloidal form has a completely unique property for the reason that it may be used as photoaging material. The exposure of UV radiation to skin can cause erythema and skin cancer. The aim of this study was to determine the physical properties of the sunscreens made from Au/ZnO and antioxidant from Moringa oleifera extract such as the sun protection factor (SPF), pH, spreadability, and adhesion. The Moringa oleifera were extracted by maceration. Maceration with 70% ethanol of dried leaves exhibited DPPH scavenging activity (EC50 235.01 μg/mL). Diffuse reflectance UV-Vis spectra of ZnO and Au/ZnO revealed absorption at λex of 385 nm which were equivalent to a bandgap energy of 3.22 eV. Au/ZnO posed a localized state at λex of 385 (3.65 eV). The sunscreens with formulations F1, F2, F3, and F4 showed high SPF number of 20.1479, 21.0008, 22.3872, and18.4631. Kruskal-Wallis test showed significant differences between sunscreen formulations.
Sintesis Senyawa Koordinasi Astaxanthin Dengan Bantuan Gelombang Ultrasonik Rokiy Alfanaar; Dion Notario
Jurnal Kimia dan Kemasan Vol. 41 No. 2 Oktober 2019
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.478 KB) | DOI: 10.24817/jkk.v41i2.3366

Abstract

Astaxanthin merupakan senyawa turunan karotenoid xantofil yang sangat potensial dalam pengobatan kanker. Salah satu upaya meningkatkan aktivitas anti kanker dari astaxanthin adalah dengan menggabungkan senyawa astaxanthin dengan ion logam. Upaya sintesis senyawa koordinasi astaxanthin dengan ion logam Fe3+, Mn2+, dan Zn2+ telah dilakukan dengan bantuan gelombang ultrasonik. Panjang gelombang maksimal senyawa kompleks Mn(II)-Astaxanthin adalah 473 nm, Fe(III)-Astaxanthin adalah 355 nm, dan Zn(II)-Astaxanthin adalah 473 nm. Hasil FTIR menunjukan munculnya gugus fungsi khas astaxanthin pada semua kompleks dan munculnya serapan pada 535 cm-1, untuk kompleks Mn(II)-Astaxanthin, 397 cm-1 untuk Fe(III)-Astaxanthin, dan 535 cm-1 untuk Zn(II)-Astaxanthin yang mengindikasikan adanya ikatan logam dengan atom donor dari Astaxanthin.
Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D Rollando Rollando; Rokiy Alfanaar
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.886 KB) | DOI: 10.12928/pharmaciana.v7i2.6699

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. 
STUDI KINETIKA DAN ISOTERM ADSORPSI BESI(III) PADA ZEOLIT ALAM DENGAN BANTUAN GELOMBANG SONIKASI Rokiy Alfanaar; Yuyun Yuniati; Zuri Rismiarti
EduChemia (Jurnal Kimia dan Pendidikan) Vol 2, No 1 (2017): Available Online in January 2017
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.045 KB) | DOI: 10.30870/educhemia.v2i1.1297

Abstract

Abstract: Fe3+ ion is one type of heavy metal waste that is often encountered from the rest of the industrial processes and laboratory education. Adsorption using natural zeolite is one way of reducing the content of Fe3+ ions. Sonication waves can influence the adsorption process that happens. Adsorption of Fe3+ by sonication assisted natural zeolite follows 1st order kinetics base on Santosa equation with R2 value =0.928. Isothermal adsorption of this study follow Freundlich equation with R2 value = 0.948, n= 1.789 and KF = 1.832.Abstrak: Ion Fe3+ adalah salah satu jenis limbah logam berat yang sering dijumpai dari sisa proses industri dan laboratorium pendidikan. Adsorpsi menggunakan zeolit alam adalah salah satu cara mengurangi kandungan ion Fe3+.Gelombang sonikasi dapat mempengaruhi proses adsorpsi yang terjadi. Adsorpsi Fe3+ zeolit alam dengan bantuan gelombang sonikasi mengikuti kinetika orde 1 berdasarkan persamaan Santosa dengan nilai R2 = 0.928. Isoterm adsorpsi pada penelitian ini mengikuti isoterm Freundlich dengan nilai R2 = 0.948, n = 1.789, dan KF = 1.832.
PELATIHAN DAN PEMBUATAN INFOGRAFIK PENGUKURAN KUALITAS TANAH DI DESA GONDOWANGI Rokiy Alfanaar; Ruth Febriana Kesuma; Rollando ,
JPM17: Jurnal Pengabdian Masyarakat Vol 5 No 01 (2020)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30996/jpm17.v5i01.3256

Abstract

Desa Gondowangi adalah salah satu desa yang sebagian penduduknya mengandalkan sektor pertanian. Pada umumnya, petani di Desa Gondowangi mengalami masalah bedanya hasil pertanian dari berbagai lahan yang dimiliki. Pengabdian masyarakat ini dilaksanakan dengan metode pelatihan pengukuran kualitas tanah dan pembuatan infografik kualitas tanah. Kegiatan pengabdian dilaksanaan dengan cara pelatihan secara langsung di lahan milik para petani. Pelatihan pengukuran dilaksanakan secara langsung oleh petani pemilik lahan sehingga petani terbiasa menggunakan soil meter. Berdasarkan hasil pengabdian didapatkan berbagai lahan memiliki kualitas tanah yang berbeda dari segi pH dan kandungan unsur hara.
Silver nanoparticle based alcohol sensor manufacturing training for detection of halal drinks Chresiani Destianita Yoedistira; Muhammad Hilmi Afthoni; Rokiy Alfanaar
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol 6, No 4 (2021): November 2021
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v6i4.5124

Abstract

Nowadays, halal drinks are one of the sectors that get the attention of various parties. Alcohol in beverages is important in determining the halalness of a beverage. Halal detection can be done using chemical sensors. In the Pharmacy Department, knowledge of analysis using sensors is rare. Therefore, this community service program was carried out to introduce qualitative methods of quick and simple alcohol analysis. The participants are students of the Pharmacy Department of STIKES Anwar Medika in Sidoarjo City. Participants are communities engaged in the health sector who have an interest in halal and how to make sensors for halal testing. This program is implemented by making a video on how to make a chemical sensor for alcohol detection. The chemical sensor is a paper-immobilized colloidal silver-based chemical sensor that is easy to apply in various conditions. Based on the results of the color change produced on the filter paper, from green to bluish which indicates that the food or beverage sample contains alcohol. Based on the questionnaire, participants expressed satisfaction with the increase in knowledge about additional tools that are easy and fast to detect alcohol.
TES CEPAT UNTUK DETEKSI ALBUMINURIA BERBASIS PERAK IODIDA(AgI) dan METILEN BIRU M. H. Afthoni; R. Alfanaar; E. Monica; R. Rollando; W. Swastika; P. N. Alfiyandri
Jurnal Kimia (Journal of Chemistry) Vol. 16, No.2, Juli 2022
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2022.v16.i02.p02

Abstract

Albuminuria adalah kondisi adanya albumin pada urin. Adanya albumin dapat menjadi indikator penyakit ginjal dan kardiovaskular. Albumin dapat dideteksi berdasarkan perubahan warna biru menjadi kecoklatan menggunakan sensor perak iodida – metilen biru. Tujuan dari pengembangan tes cepat ini adalah mendeteksi albuminuria pada urin dengan memanfaatkan reagen perak iodida (AgI) dan metilen biru. Sensor kimia yang dikembangkan merupakan sensor kolorimetri yang terimobilisasi kertas dan dideteksi dengan metode scannometri. Analisis perubahan warna sensor untuk albumin pada penelitian ini menggunakan perangkat lunak imageJ. Sensor albumin berbasis perak iodida - metilen biru yang diusulkan memiliki waktu respon 7 menit dengan rentang linier 200 hingga 500 ppm dan batas deteksi adalah 83,039 ppm batas kualifikasi. Sensor memiliki reprodusibilitas (RSD = 2,6917%) dengan waktu pakai lebih dari 5 bulan dengan nilai akurasi 100,662%. Kata kunci: albuminuria, sensor kimia, tes cepat. ABSTRACT Albuminuria is a condition of the presence of albumin in the urine. The presence of albumin can be an indicator of kidney and cardiovascular diseases. Albumin can be detected based on the change of color from blue to brownish using a silver iodide – methylene blue sensor. This rapid test was developed to detect albuminuria in the urine by utilizing silver iodide (AgI) and methylene blue reagents. The chemical sensor was a colorimetric sensor immobilized with paper and detected by scannometric methods. The analysis of the sensor color changes for albumin was carried out using ImageJ software. The proposed silver iodide - methylene blue-based albumin sensor had a response time of 7 minutes with a linear range from 200 to 500 ppm and the detection limit of 83,039 ppm qualification limit. The sensor had reproducibility (RSD = 2.6917%) with a service life of more than 5 months with an accuracy value of 100.662%. Keywords: albuminuria, chemical sensor, rapid test.
Co-Authors Adi, Mika Agung Samudra Ahmad Rifai Al-Hadi, Risfa Aliya Ansori Rahman Arif Cahyo Imawan Arsana, Mu afa Ayu, Regina Wahyudyah Sonata Aziza, S. Alfiyah Nur Chresiani Destiana Yoedistira Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Chuchita, Chuchita Citrariana, Shesanthi Citrariana, Shesanti Defilia Anogra Riani Desindria, Galang Rizdho Devi Natalia Dewi, Apriana Dion Notario Dita Monita E. Monica Efriyana oksal Elda Alyatikah Elfrida Roulina Simanjuntak Elon Jipasca Fatah, Abdul Hadjranul Fatchiyatun Ni’mah Fatiqin, Awalul Febri Nur Ngazizah Febriana Kesuma, Ruth Ferry Purwanto Gatut Ari Wardani Gerung, Jenny Blessia Gunawan, Yohanes Edy Haq, Muhammad Hasanul I Nyoman, Sudyana, Indri Susanti Iqbal, Rendy Muhamad Iqbal, Rendy Muhamad Isaura Silalahi, Anastasya Jipasca, Elon Jumiati Jumiati Jumiati Jumina Jumina Karelius, Karelius Karyadi Karyadi Karyadi Karyadi Kestrilia Rega Prilianti Krisfian Tata Aneka Priyangga Kurniawan, Yehezkiel Steven Lilis Rosmainar Lilis Rosmainar Mariasa, Joice Cleriska Markus Angkawijaya Marvin Horale Pasaribu Melany Melany Miranti Maya Sylvani Mokhamat Ariefin Monica, Eva Monita, Dita Muhamad Iqbal, Rendy Muhamad Taufik Hidayat Muhammad Hilmi Afthoni Muhammad Rifqi Shodri Mulani Jeni Lestari Tampubolon Mu’afa Purwa Arsana Nababan, Jessicca Nainggolan, Yuni Natania Gracia, Amanda Ngazizah, Febri Nur Norhusna, Norhusna Nur Hidayat Oksal, Efriyana P. N. Alfiyandri Pandu Gizta Rapi Paksi Parametta, Vidya Pramudita, Dimas Putri Wineni Putu Indrajaya Lembut Rahman, Ansori Rahman, Sudarman Rahmi Wulandari, Oktavia Rasidah Rasidah Rasidah Rasidah, Rasidah Retno Agnestisia Riaa Safitri Riana, Shesanti Citra Riandy Putra Riani, Defilia Rizki Rachmad Saputra Rollando, Rollando Ruth Febriana Kesuma Ruth Febriana Kesuma Ryu Pratiwi, Djihan Sahari, Yudhi Ekakristian Sandi Mahesa Yudhantara Saputra, Mika Adi Sari Namarito Simarmata Shesanti Citra Riana Shesanti Citra Riana Shodri, Muhammad Rifqi Simajuntak, Ruth Riama Simbolon, Wenika Siti Sunariyati Siti Unvaresi Misonia Beladona Solly Aryza Sri Juari Santosa Steven , Kur Yehezkiel Sugiani, Tina Sulistia, Tiya Sultan Arif Rahmadianto Susanto, FX. Haryanto Tety Wahyuningsih Manurung Thathit Suprayogi Titik Andriani, Titik Utami Irawati W. Swastika Wahyu Nugroho Wahyuningsih Manurung, Tety Wilda, Robiatul Witari Yahya Febrianto Yanetri Asi Nion, Yanetri Asi Yoedistira, Chresiani Yoedistira, Chresiani Destiana Yohanes Edi Gunawan Yosaeunike, Vitatani Yudhi Ekakristian Sahari Yulita, Elia Yuneta Yuyun Yuniarti, Yuyun Yuyun Yuniati Yuyun Yuniati Zaki, Azmi Malya Zimon Pereiz Zuri Rismiarti Zuri Rismiarti