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All Journal Medicinus : Jurnal Kedokteran
Amalia, Shania Rizky
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Medicine & Pharmacology Public Health

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The Role of Glycemic Load, Dairy, and Fatty Acids in Acne Disorders: A Systematic Review and Meta-Analysis Limanda, Claudia Felicia; Mathlubaa, Asya; Istikanto, Ferdian Harum; Sisca; Nabila, Yusra; Amalia, Shania Rizky; Putri, Syafira Ayudiah Syah; Ilmiani, Tasya Khalis; Hartanto, Ericko; Nurfadhila, Melinda
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10771

Abstract

Background: Modern dietary patterns characterized by high glycemic load, dairy consumption, and imbalanced fatty acid profiles may aggravate acne through insulin, IGF-1, and inflammatory pathways. However, findings across studies remain inconsistent. This systematic review and meta-analysis aimed to evaluate the associations between dietary glycemic load, glycemic index, dairy intake, and fatty acid composition with acne disorders. Methods: Following PRISMA 2020 guidelines, PubMed, EMBASE, and Scopus were systematically searched to September 2025. Eligible human studies assessing quantitative relationships between these dietary exposures and acne risk or severity were included. Random-effects meta-analyses were performed using the Hartung–Knapp–Sidik–Jonkman method, with effect sizes expressed as standardized mean differences (SMD) or risk ratios (RR). Result: Five studies encompassing 716 participants (426 acne, 290 controls) met the inclusion criteria. Pooled estimates indicated no significant associations for glycemic load (SMD = 0.09; 95% CI −0.30 to 0.49), glycemic index (SMD = 0.09; 95% CI −0.30 to 0.49), fatty acids/adiponectin (SMD = 0.11; 95% CI −0.74 to 0.97), or dairy consumption (RR = 1.04; 95% CI 0.25 to 4.25). Heterogeneity ranged from moderate to high (I² = 65–90%). Certainty of evidence was moderate for glycemic and dairy outcomes, and low for fatty acids. Conclusions: No significant pooled associations were observed between dietary glycemic load, dairy intake, or fatty acids and acne risk. Despite biological plausibility linking diet to acne via hormonal and inflammatory mechanisms, evidence remains inconsistent. Larger, controlled trials are warranted to define the role of nutritional interventions in acne management.
The Role of Dermatovenereology in the Diagnosis and Management of Bacterial Vaginosis: A Systematic Review Eldy; Amalia, Shania Rizky; Wardianti, Flora Asri; Sitanggang, Mega Rahmani; Hakiki, Nadhira Permata
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10784

Abstract

Background: Bacterial vaginosis (BV) is a prevalent, recurrent cause of abnormal vaginal discharge with important sexual and reproductive health implications. Because symptoms overlap with candidiasis, trichomoniasis, cervicitis/STIs, and vulvar dermatoses, dermatovenereology services are central to accurate diagnosis and comprehensive care. Methods: A PRISMA-compliant systematic review searched PubMed, EMBASE, and Scopus from inception to September 1, 2023, using controlled vocabulary and keywords related to BV, diagnostic modalities (Amsel, Nugent/Gram stain, microscopy, molecular assays), and dermatovenereology/sexual health services. Screening, full-text eligibility, and narrative synthesis were performed; risk of bias was assessed using the Newcastle–Ottawa Scale. Result: From 729 records, 8 studies were included after deduplication, screening, and eligibility assessment. Studies consistently highlighted the value of objective diagnosis particularly in recurrent, atypical, or post-treatment presentations. NAAT-based testing was used mainly in referral settings and facilitated concurrent STI testing. First-line antibiotics (metronidazole or clindamycin) achieved short-term response, but recurrence was common; suppressive intravaginal metronidazole and newer recurrence-prevention approaches (e.g., astodrimer gel, Lactin-V) reduced relapse in selected populations. Conclusions: Dermatovenereology-led pathways that integrate objective testing, careful differential diagnosis, STI screening, and counseling can improve diagnostic precision and reduce BV recurrence.
Co-Authors Eldy Hakiki, Nadhira Permata Hartanto, Ericko Ilmiani, Tasya Khalis Istikanto, Ferdian Harum Limanda, Claudia Felicia Mathlubaa, Asya Nabila, Yusra Nurfadhila, Melinda Putri, Syafira Ayudiah Syah sisca Sitanggang, Mega Rahmani Wardianti, Flora Asri