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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kimia Khatulistiwa Chemistry Indonesian Journal of Chemical Research Jurnal Mandala Pharmacon Indonesia Makara Journal of Science Sewagati: Jurnal Pengabdian Masyarakat Indonesia Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia Indonesian Journal of Educational Science and Technology (Nurture) Antigen: Jurnal Kesehatan Masyarakat dan Ilmu Gizi Harmoni Sosial : Jurnal Pengabdian Dan Solidaritas Masyarakat Jurnal Inovasi dan Terapan Pengabdian Masyarakat Fundamentum: Jurnal Pengabdian Multidisiplin
Fath Dwisari
Politeknik 'Aisyiah Pontianak
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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ISOLASI DAN KARAKTERISASI SENYAWA TERPENOID EKSTRAK METANOL AKAR POHON KAYU BUTA-BUTA (Excoecaria agallocha L.) Harlia, Andi Hairil Alimuddin, Fath Dwisari,
Jurnal Kimia Khatulistiwa Vol 5, No 3 (2016): Jurnal Kimia Khatulistiwa
Publisher : Jurnal Kimia Khatulistiwa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.28 KB)

Abstract

Telah dilakukan isolasi senyawa terpenoid dari ekstrak metanol akar pohon kayu buta-buta Excoecaria agallocha L. Pada penelitian ini dilakukan ekstraksi dan fraksinasi, pemisahan dan pemurnian dengan kromatografi vakum cair dan  kromatografi kolom gravitasi. Identifikasi terpenoid dilakukan dengan kromatografi lapis tipis menggunakan reagen semprot lieberman-buchard. Analisis menggunakan spektrofotometri Fourier Transform-Infra Red terhadap isolat menunjukkan adanya serapan  gugus -OH (3456,44 dan 3410,15 cm-1),  C-H alifatik (2924,09 dan 2862,36 cm-1), C=O (1712,79 cm-1), C=C aromatik (1643,35 dan 1512,19 cm-1), dan C-O (1273,02 dan 1226,73 cm-1). Kata kunci: Excoecaria agallocha L., Isolasi, Karakterisasi, Terpenoid
Effect of methyl substituent on the solubility of 1,4-benzoquinone derivatives in n-octanol/water system Siti Mariyah Ulfa; Fath Dwisari; Ade Cintyia Sally; Mohammad Farid Rahman
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2428.245 KB) | DOI: 10.14710/jksa.23.5.142-146

Abstract

The solubility of the compound is a crucial task for new drug design. Quinone is a promising candidate to develop as a new drug. In this research, the synthesis of 1,4-benzoquinone derivatives, that is, 2-(5-bromoamyl)-3,5-dimethyl-1,4-benzoquinone (2a) and 2-(5-bromoamyl)-5-methyl-1,4-benzoquinone (2b) were carried out by decarboxylation and insertion reaction of alkyl bromides. The product 2a and 2b are purified using SiO2 gel column chromatography and analyzed by UV-Visible, FT-IR, and NMR. The yield of 2a is 13.75%, and 2b is 4.04%. The solubility of 2a and 2b, expressed by log P, is measured in the n-octanol/water (3:7 (v/v)) system by the shake flask method. The log P of 2a and 2b are 2.99 and 1.36, respectively. It is showed that the log P of 2a is higher compared to 2b. The presence of two methyl substituents on the quinone ring of 2a supports the increase of hydrophobicity of the compound in the n-octanol/water system.
Facile synthesis of 5-Isopropyl-2,3-dimethylbenzene-1,4-diol by Friedel-Crafts and Determination of Partition Coefficient in n- Octanol/Water Siti Mariyah Ulfa; Alma Miranda; Fath Dwisari; Mohammad Farid Rahman
Jurnal Kimia Sains dan Aplikasi Vol 25, No 1 (2022): Volume 25 Issue 1 Year 2022
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.25.1.7-12

Abstract

The wide therapeutic effect of quinone-based drugs has received considerable interest for a long time. In this research, Friedel-Crafts performed a facile synthesis of quinone derivatives using the mixture of Brønsted acid. Reflux of 2,3-dimethylhydroquinone (1), isopropanol, glacial acetic acid, and H2SO4 for 15 minutes gave yellow oil product of 5-isopropyl-2,3-dimethylbenzene-1,4-diol (2) as a major product. Characterization using Nuclear Magnetic Resonance (NMR) revealed the methine proton splitting for isopropyl at δ 3.13 ppm, which has a cross-coupling with aromatic carbon at δ 119.6 ppm suggested the substitution of a proton on quinone ring with isopropyl group. Analysis Fourier Transform Infra-Red (FT-IR) showed the broad spectrum of –OH, the vibration of CH sp3, and isopropyl groups. The minor products identified as 5-isopropyl-2,3-dimethylcyclohexa-2,5-diene-1,4-dione (3), 5-isopropyl-2,3-dimethyl-1,4 phenylene diacetate (4), and 2,3-dimethylbenzene-5,6-isopropyl-1,4-diol (5) confirmed from 2D HETCOR and MS analysis. The partition coefficient (log P) of compound 2 showed a higher solubility by 1.9-fold compared to hydroquinone 1. It is suggested that an additional methyl group increased the partition into the organic phase.
Biological Activity and Solubility of 5-Methoxy-1,4-Benzoquinone Having Bromoheptyl and Bromodecyl Substituents in the n-Octanol/Water System Ulfa, Siti Mariyah; Dwisari, Fath; Pangesti, Laras; Rahman, Mohammad Farid
Makara Journal of Science Vol. 25, No. 1
Publisher : UI Scholars Hub

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Abstract

The biological activity and solubility of compounds are influenced by its chemical structure. These properties can be improved by substituting alkyl, alkoxy, and/or haloalkane in the parent skeleton. In this research, the synthesis of 3-(7-bromoheptyl)-2-methyl-5-methoxy-1,4-benzoquinone (3a) and 3-(10-bromodecyl)-2-methyl-5-methoxy-1,4-benzoquinone (3b) was achieved through the decarboxylation reaction. The solubility and biological activity of 3a and 3b were compared with that of thymoquinone (TQ), which acts as an anti-inflammatory agent. Compounds 3a and 3b were successfully synthesized and analyzed using Fourier Transform Infra-Red (FTIR) and Nuclear Magnetic Resonance (NMR). The FTIR spectrum showed the increasing intensity of C-H sp3 and the absorption of C-Br because of the presence of the bromoheptyl and bromodecyl substituents. 1H-NMR showed the prominent chemical shift of olefinic methylene at δ 1.29–3.40 ppm. The solubility test showed the differences in the partition coefficient (log P) of 3a and 3b in the n-octanol/water system. The log P values of 3a and 3b are higher than those of TQ, indicating that methoxy, bromoheptyl, and bromodecyl support the increase in solubility. Biological activity test using the in silico approach showed that 3a and 3b have a higher tendency to bind with the translocator protein (TSPO) macromolecule than the phosphatase and tensin homolog (PTEN) macromolecule. The binding interactions of TSPO-3a and TSPO-3b, similar to that of TSPO-TQ, showed that both synthesized compounds have comparable activity. The binding energy of TSPO-3a is lower than that of TSPO-3b, indicating that 3a has a higher activity for anti-inflammatory drug candidates than 3b.
Basic Practicum Knowledge of Medical Laboratory Technology Students: A Preliminary Study Fath Dwisari
Indonesian Journal of Educational Science and Technology Vol. 2 No. 1 (2023): February 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (998.737 KB) | DOI: 10.55927/nurture.v2i1.2983

Abstract

This study aims to determine students' perceived knowledge on writing practicum reports. The instrument used in this study was a Likert-scale questionnaire containing 14 items about students' basic knowledge in writing practicum reports from the student's point of view. The results of this study indicate that in general students have tried to write reports according to the manual provided, but some still find it difficult to interpret the results of the practicum, especially in comparing them with references from the literature in the form of theories and previous research. Students are expected to improve their ability to identify patterns and relationships emerging from the results of the practicum. Because researchers about student experiences in writing practicum reports are very rare in Indonesia, this preliminary study will be very useful for those who will research about student experiences in writing practicum reports and can be a foundation in researching the perspectives of instructors/lecturers as well as corpus research discussing the results of student reports.
PENYULUHAN PENCEGAHAN CACINGAN PADA MASYARAKAT DI DESA SUNGAI KUNYIT HULU, KABUPATEN MEMPAWAH Abdurraafi' Maududi Dermawan; Fath Dwisari; Fitri Khotimatus Sa'adah; Tri Utari
Jurnal Inovasi dan Terapan Pengabdian Masyarakat Vol. 3 No. 1 (2023)
Publisher : Politeknik 'Aisyiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35721/jitpemas.v3i1.65

Abstract

Worm infection is a disease caused by the transmission of Soil Transmitted Helminth (STH) parasites. Currently, deworming control, especially in rural communities, which involves government control and local health centers in tackling worm infections, is limited. Therefore, strategies are needed to control worm infections. The actions that can be taken to prevent worm infections are promotive and preventive. One of these strategies is realized through the implementation of promotive and preventive measures. The education was conducted on October 13, 2022. The number of participants who attended the counseling was 19 people consisting of Posyandu volunteers and residents of Sungai Kunyit Hulu Village. Based on the results of the questionnaire, an average of 86.32% of participants already knew about worms, symptoms, and characteristics of worms in children, causes, and ways to prevent worms. In addition, the post-test results showed that 94.7% of participants were able to answer correctly questions related to the causes of worms, 100% of participants were able to answer correctly about the characteristics of children infected with worms, 89.47% of participants answered correctly how to prevent worms and 100% of participants answered correctly the actions that must be taken if symptoms of worms are found.
Gambaran Tingkat Pengetahuan Siswa terhadap Demam Berdarah Dengue di SDN 18 Delta Pawan Fath Dwisari; Abdurraafi’ Maududi Dermawan; Nurza Wahyuningsih; Samsiah Samsiah
Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia Vol. 3 No. 3 (2024): September : Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia
Publisher : Sekolah Tinggi Ilmu Administrasi Yappi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jppmi.v3i3.1469

Abstract

The public health quandary in Indonesia encompasses the presence of Dengue Hemorrhagic Fever (DHF). DHF is frequently encountered in tropical and subtropical regions. The World Health Organization (WHO) has recorded Indonesia as the nation with the highest incidence of DHF in Southeast Asia. To avert DHF, it is imperative to engage in routine eradication of mosquito breeding grounds. Moreover, augmenting public cognizance and comprehension regarding DHF prevention through educational outreach is of paramount importance. The objective of this initiative is to ascertain the level of knowledge about DHF among students at SDN 18 Delta Pawan, Delta Pawan District, Ketapang Regency. The methodology employed includes lectures, discussions, and Q&A sessions, with a sample size of 35 respondents. The findings revealed that the students' knowledge at SDN 18 Delta Pawan fell into the High category for 12 students (34.3%) and the Low category for 23 students (65.7%). It can be inferred that this educational outreach was fairly beneficial in enhancing the students' knowledge about dengue hemorrhagic fever at SDN 18 Delta Pawan.
An Educational Outreach on The Health Benefits of Vitamin C and A Demonstration of Its Testing Methods at MAN 3 Pontianak Dwisari, Fath; Dermawan, Abdurraafi' Maududi; Tjoadri, Tessa Nathalia; Jumadilah, Rahmi; Afriani, Natia
SEWAGATI: Jurnal Pengabdian Masyarakat Indonesia Vol. 4 No. 1 (2025): Maret: Jurnal Pengabdian Masyarakat Indonesia
Publisher : BADAN PENERBIT STIEPARI PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56910/sewagati.v4i1.2711

Abstract

The impact of neglecting vitamin intake, particularly vitamin C, extends beyond diminished immune function to include a reduction in metabolic processes, which can subsequently impair learning concentration and lead to declines in academic performance and nutritional status among students. Vitamin C is an essential micronutrient crucial for human health, serving as a potent antioxidant and bolstering the immune system. This study aims to provide education on various sources of vitamin C and its health benefits, as well as demonstrate vitamin C identification among students at MAN 3 Pontianak. This research is a descriptive design with a one-group pretest-posttest framework, involving 30 respondents. The findings reveal that out of 30 students (100%), the majority were aged 16 years, comprising 22 individuals (73.3%). The predominant gender among respondents was female, with 20 individuals (66.7%), while male respondents numbered 10 (33.3%). Prior to the educational intervention, student knowledge was categorized as good for 17 individuals (56.7%), adequate for 12 individuals (40%), and poor for 1 individual (3.3%). Following the educational intervention, all 30 students (100%) were classified as having good knowledge. This indicates a significant enhancement in the overall knowledge of vitamin C sources and their health benefits among students at MAN 3 Pontianak after the educational program.
Edukasi Peran Zat Besi pada Pencegahan Anemia di SMP Negeri 06 Ketapang Dwisari, Fath; Dermawan, Abdurraafi' Maududi; Amalia, Puspa; Azmi, Khulul; Ramadhani, Natasya Intan; Purwanti, Desi Asih
Harmoni Sosial : Jurnal Pengabdian dan Solidaritas Masyarakat Vol. 2 No. 3 (2025): Juli : Harmoni Sosial : Jurnal Pengabdian dan Solidaritas Masyarakat
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/harmoni.v2i3.1809

Abstract

Anemia is a common health problem among adolescents, often caused by iron deficiency. This educational activity aimed to improve students' knowledge about the role of iron in preventing anemia. The program was conducted at SMP Negeri 06 Ketapang and involved 35 students as respondents. The results showed that after the educational session, the majority of students were in the moderate knowledge category (19 students or 54.3%), followed by the high category (7 students or 20%) and the low category (9 students or 25.7%). It can be concluded that this educational activity was quite beneficial in increasing students’ knowledge about the importance of iron in anemia prevention.
Edukasi Bahaya Formalin, Cara Identifikasi dan Upaya Penurunan Risiko pada Produk Pangan di MAN 3 Pontianak Dermawan, Abdurraafi' Maududi; Dwisari, Fath; Jumadilah, Rahmi; Tjoadri, Tessa Nathalia
FUNDAMENTUM : Jurnal Pengabdian Multidisiplin Vol. 2 No. 3 (2024): Agustus : FUNDAMENTUM : Jurnal Pengabdian Multidisiplin
Publisher : Asosiasi Peneliti Dan Pengajar Ilmu Sosial Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/fundamentum.v2i3.342

Abstract

The use of formalin as a food additive is prohibited according to Indonesian Minister of Health Regulation No. 033 of 2012 concerning Food Additives (BTP). Due to its easy availability and its ability to extend shelf life, formalin is often misused as a food preservative. Given its carcinogenic properties, the use of formalin in food poses health risks. The purpose of this community service is to provide education on the dangers of formalin, identification techniques for formalin, and de-formalization efforts in food products. The community service was conducted on July 25, 2024, with 30 students from MAN 3 Pontianak participating. The service was carried out using an outreach method at MAN 3 Pontianak, including pre-tests, material delivery, demonstrations, and post-tests. The results from the pre-test and post-test show an average knowledge increase of 19% regarding formalin risks and reduction efforts. Following the education through material presentation and demonstrations, the number of students with good knowledge increased to 26 (86.7%), while those with insufficient knowledge decreased to 4 (13.3%). The attitude assessment revealed that all students at MAN 3 Pontianak had a positive attitude towards the dangers of formalin and efforts to reduce formalin risks in food (100%).
Co-Authors Ade Cintyia Sally Afriani, Natia Alma Miranda Amalia, Puspa Azmi, Khulul Dermawan, Abdurraafi Maududi Dwi Haryadi Fitri Khotimatus Sa'adah Jumadilah, Rahmi Mohammad Farid Rahman Mohammad Farid Rahman Nurza Wahyuningsih Pangesti, Laras Purwanti, Desi Asih Rahma, Nur Atika Ramadhani, Natasya Intan Samsiah Samsiah Siti Mariyah Ulfa Tjoadri, Tessa Nathalia Tri Utari