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All Journal Buletin Veteriner Udayana
Samsuri
Laboratorium Farmakologi dan Farmasi Veteriner, Fakultas Kedokteran Hewan, Universitas Udayana, Jl. PB. Sudirman, Denpasar, Bali, Indonesia, 80234
Immunology & microbiology Public Health Veterinary

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MICROBIAL CONTAMINATION TEST NUMBER OF YEAST MOLD SIMPLICIA MARIGOLD FLOWERS AS STANDARD RAW MATERIAL FOR HERBAL MEDICINE Maulia Suciani; I Made Merdana; Samsuri; Nyoman Adi Suratma
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2025 Vol. 17 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i03.p15

Abstract

The marigold plant is widely cultivated for medicinal purposes, as an ornamental plant and natural food colouring. Marigold flowers (Tagetes erecta L.) contain secondary metabolites in the form of terpenoids, essential oils, phenols, flavonoids, carotenoids, and so on. Looking at its contents and pharmacological benefits, marigold flowers have the potential to be used as simplicia as a raw material for herbal medicine. This research aims to determine the value of Total Yeast and Mold Count (TYMC) test simplicia marigold flower (Tagetes erecta L.) as a raw material for medicinal preparations based on microbial contamination standards according to the General Standard Parameters of BPOM RI Regulation Number 32 of 2019 concerning Quality Requirements for Traditional Medicines. This research is a type of non-experimental observational research because there is no treatment of the research object with a research design in the form of descriptive-quantitative analysis. The level of microbial contamination is reviewed through the Yeast and Mold Count (TYMC) test. The research data obtained was quantitative data which was analyzed by counting the number of microbes that grew on Potato Dextrose Agar (PDA) media after incubation at the appropriate growth temperature. The Total Yeast and Mold Count is 1,4 x 102 CFU/gram. The research results showed that marigold flower simplicia met the microbial contamination requirements for yeast and Mold Count numbers (≤5x105). It can be concluded that the mimosa leaves simplicia sample can be processed into drug preparations. Further research is needed on pathogenic microbial contamination, as well as additional quality standardization tests on marigold (Tagetes erecta L.) simplicia.
THE EFFECT OF GIVING GAMAL LEAF BLOCK ON THE HEMATOLOGICAL PROFILE OF CATTLE EXPERIENCING ANESTRUS Resinta Delia Rahmadani; Samsuri; I Nengah Wandia; I Made Merdana; I Nyoman Sulabda; Anak Agung Sagung Kendran
Buletin Veteriner Udayana Bul. Vet. Udayana. December 2024 Vol. 16 No. 6
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2024.v16.i06.p14

Abstract

Anestrus is a condition in female animals that do not show symptoms of estrus for a long period of time. Anestrus in cows can cause physiological, environmental and management changes. Gamal leaves can be used as a source of protein for livestock. Mother cows experience fluctuating hematological changes, such as hemoglobinemia, erythropenia and leucocythemia. This study aims to determine the effect of gamal block on hemoglobin levels, total erythrocytes, hematocrit values ​​and total leukocytes in Bali cattle experiencing anestrus. This research used 6 anestrus Bali cattle selected using purposive sampling. The six cows were given gamal block treatment with a composition of 250 grams of gamal leaf simplicial, 200 ml propylene glycol and 4 grams of salt for 14 days. After that, a 2ml blood sample was taken via the jugular vein on day 0, day 10 and day 20. The results of the study obtained mean hemoglobin levels sequentially on days 0, 10 and 20, namely 8.98 ± 0.23 g/dL, 8.78 ± 0.23 g/dL, 8.26 ± 0, 23 g/dL. Total erythrocytes were 4.80±0.18 106/μL, 4.92±0.18 106/μL, 4.73±0.18106/μL respectively. Hematocrit values ​​were 29.53 ± 0.60 %, 28.23 ± 0.60 %, 26.64 ± 0.61 %, respectively. And total leukocytes were 7.21±0.27 103/μL, 7.56±0.27 103/μL, 6.63±0.27 103/μL respectively. The statistical results showed that giving gamal leaf blocks for 14 days did not affect hemoglobin levels, total erythrocytes, hematocrit values ​​and total leukocytes in Bali cattle experiencing anestrus.
EFFECTS OF CAULERPA LENTILLIFERA SIMPLISIA ADMINISTRATION ON GASTRIC AND SMALL INTESTINAL HISTOPATHOLOGY IN WHITE RATS POST PARACETAMOL INDUCTION Baiq Melisa Ulandari Utami; Ida Bagus Oka Winaya; Yudha Yaksa Crada Yoga Arum Raharjo; Samsuri; I Made Merdana
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2025 Vol. 17 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i03.p04

Abstract

Caulerpa lentillifera is known as sea grapes macroalgae or sea grapes which have benefits as antioxidants. Paracetamol is a drug that is sold freely and many people abuse it. Abuse of paracetamol can cause negative impacts on various organs, one of which is the stomach and small intestine. The purpose of this study was to determine the effect of administering Caulerpa lentillifera on the histopathology of the gastric and small intestine of white mice given paracetamol in high doses. This study used a completely randomized design method. A sample of 25 male white mice was divided into 5 treatment groups, namely negative control (P0) or no treatment, positive control (P1) was only given paracetamol 250 mg/kgBB, P2 was given paracetamol 250 mg/kgBB and sea grapes 10 g/kgBB, P3 was given paracetamol 250 mg/kgBB and sea grapes 15 g/kgBB, and P4 was given paracetamol 250 mg/kgBB and sea grapes 20 g/kgBB. Treatment was given for 14 days, then necropsied. Samples of gastric and small intestine tissue were made into histopathology preparations using hematoxylin eosin (HE) staining. The variables examined in the gastric were gastric mucosal damage. While the variables examined in the small intestine included bleeding lesions and necrosis. Data were analyzed using the Kruskal Wallis Test followed by the Mann-Whitney test and described descriptively. The results showed that in gastric mucosal damage, small intestine necrosis, and small intestine bleeding showed that there was a difference (P<0.05) between groups. There was a process of improvement in the histopathology of the gastric and small intestine of white rats given Caulerpa lentillifera in gastric mucosal damage, small intestine necrosis, and small intestine bleeding. Based on the results of the study, it can be concluded that sea grapes with doses of 15 g/kgBB and 20 g/kgBB can minimize gastric mucosal damage. While a dose of 20 g/kgBB can minimize small intestine damage in necrosis and hemorrhage lesions
THE EFFECT OF MENIRAN EXTRACT AS AN IMUNOSTIMULATOR ON THE INCREASE OF NEWCASTLE DISEASE ANTIBODY TITER IN BROILERS Muhammad Evan Malik; Ida Bagus Kade Suardana; Samsuri; Ni Luh Eka Setiasih; I Made Kardena; Tjokorda Sari Nindhia
Buletin Veteriner Udayana Bul. Vet. Udayana. April 2025 Vol. 17 No. 2
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i02.p11

Abstract

Meniran is known as an herbal plant with potential as a natural immunostimulator due to its content of flavonoids, saponins, and tannins. These compounds help boost the immune response by stimulating cytokine production, accelerating immune cell activation, and increasing antibody production. Newcastle Disease (ND) is an infectious disease that frequently affects broilers and causes significant economic losses. Vaccination is the primary method for preventing ND; however, its effectiveness can vary depending on the immune response of the chickens. This study aims to evaluate the effect of meniran extract as an immunostimulant on increasing Newcastle Disease antibody titers in booster-vaccinated broilers. This study used a Completely Randomized Design with 30 Lohman MB 202 broilers divided into three treatment groups. The negative control group (K-) received neither vaccination nor meniran extract, the positive control group (K+) received only the ND La Sota booster vaccine, and the treatment group (P) received both the ND La Sota booster vaccine and meniran extract for 14 days before vaccination. Antibody titers were measured using the Hemagglutination Inhibition (HI) test on days 17, 25, and 32. Data were analyzed using ANOVA and regression analysis. The results showed that the administration of meniran extract significantly increased antibody titers (P<0.05), with mean values of 2.7, 4.1, and 6.0 (HI log 2), and an overall mean of 4.27. Regression analysis indicated that the treatment group (P) experienced a higher increase in antibody titers compared to the control groups, with the peak immune response occurring in the third week post-vaccination. The conclusion of this study is that meniran extract can act as a natural immunostimulant that enhances the effectiveness of the ND vaccine in broiler chickens. Therefore, further research with different doses and administration durations is needed to optimize its benefits.
PROTECTIVE EFFECTS OF SEA GRAPE SIMPLICIA ON LUNG HISTOPATHOLOGY IN PARACETAMOL-INDUCED RATS Reyna Tasya Dhewanty; I Ketut Berata; Tri Komala Sari; Samsuri; I Made Merdana
Buletin Veteriner Udayana Bul. Vet. Udayana. August 2025 Vol. 17 No. 4
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i04.p10

Abstract

Caulerpa lentillifera, commonly known as sea grapes, is a green alga found in shallow sandy areas and around coral reefs. It contains chlorophyll A and B, polyphenols, flavonoids, tannins, and vitamins A, B1, B2, B6, B12, and C—all of which possess antioxidant properties. Antioxidants play a critical role in preventing and repairing cellular damage. This study aimed to evaluate the protective effects of C. lentillifera simplicia on the lung histopathology of white rats (Rattus norvegicus) induced with paracetamol. Twenty-five male rats were randomly assigned to five groups and treated over a 14-day period. Lung tissues were collected on day 15 for histopathological analysis, focusing on indicators such as hemorrhage, inflammation, congestion, and necrosis. Data were analyzed using the Kruskal–Wallis and Mann–Whitney tests. Paracetamol administration caused significant histopathological damage to lung tissues. However, rats treated with C. lentillifera simplicia exhibited notable improvements, with reduced severity of hemorrhage, inflammation, congestion, and necrosis compared to the paracetamol-only group. These findings indicate that C. lentillifera simplicia has a protective effect against paracetamol-induced lung injury, supporting its potential use as a natural antioxidant for lung tissue protection.
Co-Authors Anak Agung Sagung Kendran Baiq Melisa Ulandari Utami I Ketut Berata I Made Kardena I Made Merdana I Nengah Wandia I Nyoman Sulabda Ida Bagus Kade Suardana Ida Bagus Oka Winaya Maulia Suciani Muhammad Evan Malik Ni Luh Eka Setiasih Nyoman Adi Suratma Resinta Delia Rahmadani Reyna Tasya Dhewanty Tjokorda Sari Nindhia Tri Komala Sari Yudha Yaksa Crada Yoga Arum Raharjo