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All Journal Jurnal Kolaboratif Sains Galen: Jurnal Ilmu Farmasi dan Kesehatan Qoumun: Journal of Social and Humanities
Sri Manovita Pateda
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Cardiovascular Dysregulation in Heat Stroke Driven by Climate Change: Pathophysiology and Clinical Implications Nayla Prima Dyta; Ativa Muthia Diniyah; Andi Safa Natasya Lukman; Nadine Khaira Zahratunnisa Abdul; Fatmawati Adelia Pakaya; Sri Manovita Pateda
Jurnal Kolaboratif Sains Vol. 8 No. 12: Desember 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i12.9514

Abstract

Heat stroke is an escalating global health threat driven by rising temperatures and increasingly frequent heat waves. This study aimed to elucidate the mechanisms by which extreme heat exposure precipitates cardiovascular injury and hemodynamic collapse, and to identify biomarkers predictive of poor outcomes. A mixed-methods design integrating ecological time-series analysis with a prospective clinical cohort was employed. Distributed Lag Non-linear Models were used to quantify the association between ambient temperature and cardiovascular mortality over a 20-year period, showing a 2.1% increase in risk per 1°C temperature rise above local thresholds. Clinically, 70% of heat stroke patients demonstrated elevated troponin levels above the 99th percentile, while 55% exhibited BNP elevation. Inflammatory markers such as IL-6 (>80 pg/mL) and D-dimer (>1.5 µg/mL) were strongly associated with progression to multi-organ dysfunction. Hemodynamic assessments revealed an early hyperdynamic state followed by reduced ejection fraction and hypotension within 24–36 hours, consistent with myocardial stunning. Atypical presentations, including ventricular fibrillation with normal surface temperature, underscored diagnostic challenges and highlighted the importance of core-temperature monitoring. These findings indicate that cardiovascular failure in heat stroke arises from both thermoregulatory overload and direct myocardial injury, compounded by systemic inflammation and coagulopathy. The study contributes new insights into biomarker-driven risk stratification and emphasizes the need for precision diagnostic tools and enhanced public health interventions in an era of intensifying climate stress.
The Use of Corn Cob and Leaf Waste (Zea mays L.) as Herbal Support for Malaria Prevention: A Social–Humanities Approach Based on Laboratory Evidence Uno, Wiwit Zuriati; Dian Pratiwi Iman; Rifka Anggraini Anggai; Mahdalena Sy Pakaya; Sri Manovita Pateda
Qoumun: Jurnal Pengabdian Masyarakat Vol 1 No 2 (2025): Qoumun: Journal of Social and Humanities
Publisher : Cv. Kayaswara

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Abstract

Corn cobs and corn leaves (Zea mays L.) are abundant agricultural wastes with potential bioactive value. This study aimed to evaluate the extraction efficiency, phytochemical profile, and antioxidant activity of corn cob and corn leaf extracts obtained using solvents of different polarities, and to assess their relevance as supportive herbal resources for health promotion. Samples were extracted using ethanol, acetone, and n-hexane, followed by phytochemical screening and antioxidant evaluation using the DPPH method. The results demonstrated that ethanol extracts produced the highest yields and exhibited very strong antioxidant activity, indicated by low IC₅₀ values. These findings suggest that polar phytochemicals, particularly phenolic and flavonoid compounds, are the main contributors to the antioxidant potential of corn waste materials. Overall, this study provides scientific evidence supporting the valorization of corn agricultural waste as a sustainable source of antioxidant-rich herbal materials with potential relevance for oxidative stress management.
Mengatasi Ilusi Pengetahuan: Edukasi RHA Mengubah Pemahaman menjadi Kompetensi Operasional dalam Respon Bencana Taqi Akilah Halid; Zuhriana K. Yusuf; Romy Abdul; Sri Manovita Pateda; Muhamad Nur Syukriani Yusuf
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i1.132

Abstract

Indonesia menghadapi risiko bencana tertinggi kedua di dunia, sehingga diperlukan kesiapsiagaan tenaga kesehatan, khususnya dalam pelaksanaan Rapid Health Assessment. Mahasiswa kesehatan sebagai calon tenaga kesehatan memerlukan pemahaman mendalam mengenai RHA, namun tingkat pengetahuan mereka masih perlu dikaji.  Penelitian ini bertujuan menganalisis pengaruh edukasi terhadap pengetahuan mahasiswa kesehatan tentang RHA di Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Penelitian menggunakan desain quasi pre-experimental dengan pendekatan one-group pre-test and post-test. Sebanyak 30 mahasiswa aktif angkatan 2022 dari program studi Kesehatan Masyarakat, Keperawatan, dan Farmasi dipilih melalui Proportional stratified random sampling. Pengumpulan data menggunakan kuesioner tervalidasi berbasis Skala Guttman dengan 10 pertanyaan. Intervensi berupa edukasi RHA menggunakan metode ceramah dan diskusi interaktif. Analisis data dilapkukan dengan uji Wilcoxon Signed Rank Test. Hasil sebelum edukasi, tingkat pengetahuan mahasiswa menunjukkan kategori cukup sebesar 53,3%, baik 43,3%, dan kurang baik 3,3%. Setelah edukasi, terjadi peningkatan signifikan dengan kategori baik mencapai 93,3% dan cukup 6,7%. Simpulan terdapat pengaruh signifikan pemberian edukasi terhadap peningkatan pengetahuan mahasiswa kesehatan tentang Rapid Health Assessment di Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo.   
Co-Authors Andi Safa Natasya Lukman Ativa Muthia Diniyah Dian Pratiwi Iman Fatmawati Adelia Pakaya Mahdalena Sy Pakaya Muhamad Nur Syukriani Yusuf Nadine Khaira Zahratunnisa Abdul Nayla Prima Dyta Rifka Anggraini Anggai Romy Abdul Taqi Akilah Halid Wiwit Zuriati Uno Zuhriana K. Yusuf