Juliani R. Turang
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon

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Antibacterial Activity Test of Scleria sumatrensis Leaf Extract against Staphylococcus aureus in Vitro Douglas N. Pareta; Reky R. Palandi; Selvana S. Tulandi; Juliani R. Turang; Alter Y. Runtu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.506

Abstract

Staphylococcus aureus bacteria is one of the important pathogens that can cause various types of infections, ranging from mild ones such as folliculitis and impetigo to life-threatening conditions such as nosocomial pneumonia, osteomyelitis, endocarditis, sepsis, and toxic shock syndrome. Due to its ability to develop resistance to antibiotics, new alternative treatments are needed, one of which is from natural ingredients. In this study, the antibacterial activity of Scleria sumatrensis extract was tested against Staphylococcus aureus with a concentration variation of 100 - 500 µg / disc. The results showed that at a concentration of 100 ?g / disc, the extract provided antibacterial activity in the moderate category, while at a concentration of 200 to 500 ?g / disc, the activity produced was included in the strong category. These findings indicate that Scleria sumatrensis extract has the potential as a natural antibacterial agent against Staphylococcus aureus, so it is worthy of further development as an alternative therapy for infections caused by S. aureus bacteria.
Antipyretic Activity of Avocado Seed (Persea americana) Infusion in Pepton-Induced Fever in Male White Rats Rattus norvegicus Wilmar Maarisit; Dannari Sampetondok; Reky R. Palandi; Juliani R. Turang; Friska M. Montolalu; Hariyadi Hariyadi; Amal R. Ginting
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.525

Abstract

Avocado seeds (Persea americana) have long been used in traditional medicine and are empirically believed to reduce fever. This study aimed to evaluate the antipyretic activity of an avocado seed infusion in male white rats (Rattus norvegicus) induced with peptone. The infusion was prepared using distilled water at 90 °C. The antipyretic test consisted of five groups: a negative control (Na-CMC), a positive control (paracetamol), and three treatment groups receiving avocado seed infusion at doses of 100, 200, and 300 mg/200 g body weight. Fever was induced by intramuscular injection of 5% peptone (1 mL/200 g body weight). Rectal temperature was recorded at 30-minute intervals for 3 hours. The results showed that all treatment doses reduced rectal temperature after 180 minutes. The greatest reduction was observed at a dose of 300 mg/200 g body weight, with a decrease of 2.16 °C, indicating that avocado seed infusion exhibits dose-dependent antipyretic activity.